{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:41:38Z","timestamp":1648986098245},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"S7","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1186\/s12859-019-2731-7","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:03:08Z","timestamp":1556668988000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systems biology intertwines with single cell and AI"],"prefix":"10.1186","volume":"20","author":[{"given":"Yong","family":"Wang","sequence":"first","affiliation":[]},{"given":"Xiang-Sun","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Luonan","family":"Chen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"issue":"6","key":"2731_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.tibtech.2010.03.002","volume":"28","author":"D Wang","year":"2010","unstructured":"Wang D, Bodovitz S. Single cell analysis: the new frontier in 'omics. Trends Biotechnol. 2010;28(6):281\u201390.","journal-title":"Trends Biotechnol"},{"issue":"141","key":"2731_CR2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2017.0387","volume":"15","author":"T Ching","year":"2018","unstructured":"Ching T, Himmelstein DS, Beaulieu-Jones BK, et al. Opportunities and obstacles for deep learning in biology and medicine. J R Soc Interface. 2018;15(141):20170387.","journal-title":"J R Soc Interface"},{"issue":"Suppl 2","key":"2731_CR3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1752-0509-4-S2-S1","volume":"4","author":"Y Wang","year":"2010","unstructured":"Wang Y, Zhang X-S, Chen L. Optimization meets systems biology. BMC Syst Biol. 2010;4(Suppl 2):S1.","journal-title":"BMC Syst Biol"},{"issue":"Suppl 1","key":"2731_CR4","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1752-0509-5-S1-S1","volume":"5","author":"Y Wang","year":"2011","unstructured":"Wang Y, Zhang X-S, Chen L. Computational systems biology: integration of sequence, structure, network, and dynamics. BMC Syst Biol. 2011;5(Suppl 1):S1.","journal-title":"BMC Syst Biol"},{"issue":"Suppl 1","key":"2731_CR5","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1752-0509-6-S1-S1","volume":"6","author":"Y Wang","year":"2012","unstructured":"Wang Y, Zhang X-S, Chen L. Modelling biological systems from molecules to dynamical networks. BMC Syst Biol. 2012;6(Suppl 1):S1.","journal-title":"BMC Syst Biol"},{"issue":"Suppl 1","key":"2731_CR6","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1752-0509-7-S2-S1","volume":"7","author":"Y Wang","year":"2013","unstructured":"Wang Y, Zhang X-S, Chen L. Computational systems biology in the big data era. BMC Syst Biol. 2013;7(Suppl 1):S1.","journal-title":"BMC Syst Biol"},{"issue":"Suppl 4","key":"2731_CR7","first-page":"S1","volume":"11","author":"Y Wang","year":"2017","unstructured":"Wang Y, Zhang X-S, Chen L. Understanding biological systems through the lens of data. BMC Syst Biol. 2017;11(Suppl 4):S1.","journal-title":"BMC Syst Biol"},{"issue":"Suppl 4","key":"2731_CR8","first-page":"S1","volume":"12","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zhang X-S, Chen L. Integrating data-and model-driven strategies in systems biology. BMC Syst Biol. 2018;12(Suppl 4):S1.","journal-title":"BMC Syst Biol"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-2731-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-019-2731-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-2731-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T23:09:38Z","timestamp":1588201778000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-019-2731-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":8,"journal-issue":{"issue":"S7","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["2731"],"URL":"https:\/\/doi.org\/10.1186\/s12859-019-2731-7","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"1 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"204"}}