{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:43:05Z","timestamp":1791510185091,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"S12","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1186\/s12859-019-2839-9","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:02:39Z","timestamp":1560988959000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A stochastic model of size control in the budding yeast cell cycle"],"prefix":"10.1186","volume":"20","author":[{"given":"Mansooreh","family":"Ahmadian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Tyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"issue":"2 pt 1","key":"2839_CR1","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1083\/jcb.75.2.422","volume":"75","author":"LH Hartwell","year":"1977","unstructured":"Hartwell LH, Unger MW. Unequal division in saccharomyces cerevisiae and its implications for the control of cell division. J Cell Biol. 1977; 75(2 pt 1):422\u201335.","journal-title":"J Cell Biol"},{"key":"2839_CR2","volume-title":"The Cell Cycle","author":"BLA Carter","year":"1981","unstructured":"Carter BLA. The control of cell division in saccharomyces cerevisiae In: John PCL, editor. The Cell Cycle. Cambridge, UK: Cambridge University Press: 1981. p. 99\u2013117."},{"key":"2839_CR3","volume-title":"The cell cycle: An introduction","author":"A Murray","year":"1993","unstructured":"Murray A, Hunt T. The cell cycle: An introduction. New York: W.H. Freeman; 1993."},{"key":"2839_CR4","volume-title":"Molecular biology of the cell, 3rd ed","author":"B Alberts","year":"1994","unstructured":"Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular biology of the cell, 3rd ed. New York: Garland Publishing; 1994."},{"issue":"1329","key":"2839_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1098\/rstb.1995.0113","volume":"349","author":"K Nasmyth","year":"1995","unstructured":"Nasmyth K. Evolution of the cell cycle. Philos Trans R Soc Lond B. 1995; 349(1329):271\u201381.","journal-title":"Philos Trans R Soc Lond B"},{"issue":"10","key":"2839_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0168-9525(96)10041-X","volume":"12","author":"K Nasmyth","year":"1996","unstructured":"Nasmyth K. At the heart of the budding yeast cell cycle. Trends Genet. 1996; 12(10):405\u201312.","journal-title":"Trends Genet"},{"issue":"19","key":"2839_CR7","doi-asserted-by":"publisher","first-page":"9997","DOI":"10.1073\/pnas.93.19.9997","volume":"93","author":"M Botchan","year":"1996","unstructured":"Botchan M. Coordinating dna replication with cell division: current status of the licensing concept.Proc Natl Acad Sci USA. 1996; 93(19):9997\u201310000.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2839_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0968-0004(96)10011-6","volume":"21","author":"JJ Tyson","year":"1996","unstructured":"Tyson JJ, Novak B, Odell GM, Chen KC, Thron CD. Chemical kinetic theory as a tool for understanding the regulation of m-phase promoting factor in the cell cycle. Trends Biochem Sci. 1996; 21(3):89\u201396.","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"2839_CR9","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1093\/emboj\/16.10.2693","volume":"16","author":"A Amon","year":"1997","unstructured":"Amon A. Regulation of b-type cyclin proteolysis by cdc28-associated kinases in budding yeast. EMBO J. 1997; 16(10):2693\u2013702.","journal-title":"EMBO J"},{"issue":"6","key":"2839_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0955-0674(98)80120-8","volume":"10","author":"S Biggins","year":"1998","unstructured":"Biggins S, Murray AW. Sister chromatid cohesion in mitosis. Curr Opin Cell Biol. 1998; 10(6):769\u201375.","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"2839_CR11","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/S0955-0674(98)80117-8","volume":"10","author":"J Leatherwood","year":"1998","unstructured":"Leatherwood J. Emerging mechanisms of eukaryotic dna replication initiation. Curr Opin Cell Biol. 1998; 10(6):742\u20138.","journal-title":"Curr Opin Cell Biol"},{"issue":"5394","key":"2839_CR12","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1126\/science.282.5394.1721","volume":"282","author":"W Zachariae","year":"1998","unstructured":"Zachariae W, Schwab M, Nasmyth K, Seufert W. Control of cyclin ubiquitination by cdk-regulated binding of hct1 to the anaphase promoting complex. Science. 1998; 282(5394):1721\u20134.","journal-title":"Science"},{"issue":"18","key":"2839_CR13","doi-asserted-by":"publisher","first-page":"6292","DOI":"10.1128\/MCB.21.18.6292-6311.2001","volume":"21","author":"ME Miller","year":"2001","unstructured":"Miller ME, Cross FR. Mechanisms controlling subcellular localization of the g1 cyclins cln2p and cln3p in budding yeast. Mol Cell Biol. 2001; 21(18):6292\u2013311.","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2839_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/msb.2010.112","volume":"7","author":"C. Miller","year":"2014","unstructured":"Miller C, Schwalb B, Maier K, Schulz D, D\u00fcmcke S, Zacher B, Mayer A, Sydow J, Marcinowski L, D\u00f6lken L, Martin DE, Tresch A, Cramer P. Dynamic transcriptome analysis measures rates of mrna synthesis and decay in yeast. Mol Syst Biol. 2011; 7(458). \n                    https:\/\/doi.org\/10.1038\/msb.2010.112\n                    \n                  . PMCID: PMC3049410. PMID: 21206491.","journal-title":"Molecular Systems Biology"},{"issue":"425","key":"2839_CR15","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nature02046","volume":"14","author":"S Ghaemmaghami","year":"2003","unstructured":"Ghaemmaghami S, Huh W-K, Bower K, Howson RW, Belle A, Dephoure N, O\u2019Shea EK, Weissman JS. Global analysis of protein expression in yeast. Nature. 2003; 14(425):737\u201341.","journal-title":"Nature"},{"issue":"3","key":"2839_CR16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1128\/JB.142.3.808-818.1980","volume":"142","author":"PG Lord","year":"1980","unstructured":"Lord PG, Wheals AE. Asymmetrical division of saccharomyces cerevisiae. J Bacteriol. 1980; 142(3):808\u201318.","journal-title":"J Bacteriol"},{"issue":"1","key":"2839_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0014-4827(77)90154-9","volume":"105","author":"GC Johnston","year":"1997","unstructured":"Johnston GC, Pringle JR, Hartwell LH. Coordination of growth with cell division in the yeast saccharomyces cerevisiae. Exp Cell Res. 1997; 105(1):79\u201398.","journal-title":"Exp Cell Res"},{"issue":"12","key":"2839_CR18","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1101\/gad.1777309","volume":"23","author":"AI Goranov","year":"2009","unstructured":"Goranov AI, Cook M, Ricicova M, Ben-Ari G, Gonzalez C, Hansen C, Tyers M, Amon A. The rate of cell growth is governed by cell cycle stage. Genes Dev. 2009; 23(12):1408\u201322.","journal-title":"Genes Dev"},{"key":"2839_CR19","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/ncomms2015","volume":"3","author":"F Ferrezuelo","year":"2012","unstructured":"Ferrezuelo F, Colomina N, Palmisano A, Gari E, Gallego C, Csikasz-Nagy A, Aldea M. The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nat Commun. 2012; 3:1012. \n                    https:\/\/doi.org\/10.1038\/ncomms2015\n                    \n                  .","journal-title":"Nat Commun"},{"key":"2839_CR20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nature14908","volume":"526(7572)","author":"KM Schmoller","year":"2015","unstructured":"Schmoller KM, Turner JJ, Koivomagi M, Skotheim JM. Dilution of the cell cycle inhibitor whi5 controls budding-yeast cell size. Nature. 2015; 526(7572):268\u201372. \n                    https:\/\/doi.org\/10.1038\/nature14908\n                    \n                  .","journal-title":"Nature"},{"issue":"3","key":"2839_CR21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.cub.2015.11.067","volume":"26","author":"I Soifer","year":"2016","unstructured":"Soifer I, Robert L, Amir A. Single-cell analysis of growth in budding yeast and bacteria reveals a common size regulation strategy. Curr Biol. 2016; 26(3):356\u201361.","journal-title":"Curr Biol"},{"issue":"9","key":"2839_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cub.2012.02.041","volume":"22","author":"JJ Turner","year":"2012","unstructured":"Turner JJ, Ewald JC, Skotheim JM. Cell size control in yeast. Curr Biol. 2012; 22(9):350\u20139.","journal-title":"Curr Biol"},{"key":"2839_CR23","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nature06072","volume":"448","author":"S Di Talia","year":"2007","unstructured":"Di Talia S, Skotheim JM, Bean JM, Siggia ED, Cross FR. The effects of molecular noise and size control on variablility in the budding yeast cell cycle. Nature. 2007; 448:947\u201352.","journal-title":"Nature"},{"issue":"16","key":"2839_CR24","doi-asserted-by":"publisher","first-page":"7328","DOI":"10.1073\/pnas.88.16.7328","volume":"88","author":"JJ Tyson","year":"1991","unstructured":"Tyson JJ. Modeling the cell division cycle: Cdc2 and cyclin interactions. PNAS. 1991; 88(16):7328\u201332.","journal-title":"PNAS"},{"issue":"2","key":"2839_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/jtbi.2001.2293","volume":"210","author":"JJ Tyson","year":"2001","unstructured":"Tyson JJ, Novak B. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. J Theor Biol. 2001; 210(2):249\u201363.","journal-title":"J Theor Biol"},{"issue":"1","key":"2839_CR26","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1091\/mbc.11.1.369","volume":"11","author":"KC Chen","year":"2000","unstructured":"Chen KC, Csikasz-Nagy A, Gyorffy B, Val J, Novak B, Tyson JJ. Kinetic analysis of a molecular model of the budding yeast cell cycle. Mol Biol Cell. 2000; 11(1):369\u201391.","journal-title":"Mol Biol Cell"},{"key":"2839_CR27","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.1091\/mbc.e03-11-0794","volume":"15","author":"KC Chen","year":"2004","unstructured":"Chen KC, Calzone L, Csikasz-Nagy A, Cross FR, Novak B, Tyson JJ. Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell. 2004; 15:3841\u201362.","journal-title":"Mol Biol Cell"},{"issue":"10","key":"2839_CR28","doi-asserted-by":"publisher","first-page":"e1000221","DOI":"10.1371\/journal.pbio.1000221","volume":"7","author":"S Di Talia","year":"2009","unstructured":"Di Talia S, Wang H, Skotheim JM, Rosebrock AP, Futcher B, Cross FR. Daughter-specific transcription factors regulate cell size control in budding yeast. PLoS Biol. 2009; 7(10):e1000221.","journal-title":"PLoS Biol"},{"issue":"6","key":"2839_CR29","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4161\/cc.10.6.14966","volume":"10","author":"DA Ball","year":"2011","unstructured":"Ball DA, Ahn T, Wang P, Chen KC, Cao Y, Tyson JJ, Peccoud J, Baumann WT. Stochastic exit from mitosis in dudding yeast. Cell Cycle. 2011; 10(6):999\u20131009.","journal-title":"Cell Cycle"},{"issue":"12","key":"2839_CR30","doi-asserted-by":"publisher","first-page":"e1005230","DOI":"10.1371\/journal.pcbi.1005230","volume":"12","author":"D Barik","year":"2016","unstructured":"Barik D, Ball DA, Peccoud J, Tyson JJ. A stochastic model of the yeast cell cycle reveals roles for feedback regulation in limiting cellular variability. PLoS Comput Biol. 2016; 12(12):e1005230.","journal-title":"PLoS Comput Biol"},{"issue":"4","key":"2839_CR31","first-page":"403","volume":"22","author":"DT Gillespie","year":"1976","unstructured":"Gillespie DT. A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J Contemp Math. 1976; 22(4):403\u201334.","journal-title":"J Contemp Math"},{"issue":"16","key":"2839_CR32","doi-asserted-by":"publisher","first-page":"8229","DOI":"10.1063\/1.1613254","volume":"119","author":"DT Gillespie","year":"2003","unstructured":"Gillespie DT, Petzold LR. Improved leap-size selection for accelerated stochastic simulation. J Chem Phys. 2003; 119(16):8229\u201334.","journal-title":"J Chem Phys"},{"issue":"2","key":"2839_CR33","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1021\/jp993732q","volume":"104","author":"MA Gibson","year":"2000","unstructured":"Gibson MA, Bruck J. Efficient exact stochastic simulation of chemical systems with many species and many channels. J Chem Phys. 2000; 104(2):1876\u201389.","journal-title":"J Chem Phys"},{"issue":"9","key":"2839_CR34","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1063\/1.1778376","volume":"121","author":"Y1 Cao","year":"2001","unstructured":"Cao Y1, Li H, Petzold L. Efficient formulation of the stochastic simulation algorithm for chemically reacting systems. J Chem Phys. 2001; 121(9):4059\u201367.","journal-title":"J Chem Phys"},{"key":"2839_CR35","doi-asserted-by":"publisher","DOI":"10.1201\/b20026","volume-title":"Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","author":"S Wang","year":"2016","unstructured":"Wang S, Ahmadian M, Chen M, Tyson JJ, Cao Y. A hybrid stochastic model of the budding yeast cell cycle control mechanism. In: Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. New York: ACM: 2016. p. 261\u2013270."},{"issue":"19","key":"2839_CR36","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.4161\/cc.26257","volume":"12","author":"DA Ball","year":"2013","unstructured":"Ball DA, Adames NR, Reischmann N, Barik D, Franck CT, Tyson JJ. Measurement and modeling of transcriptional noise in the cell cycle regulatory network. Cell Cycle. 2013; 12(19):3203\u201318.","journal-title":"Cell Cycle"},{"key":"2839_CR37","volume-title":"Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","author":"M Ahmadian","year":"2017","unstructured":"Ahmadian M, Wang S, Tyson JJ, Cao Y. Hybrid ode\/ssa model of the budding yeast cell cycle control mechanism with mutant case study. In: Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. New York: ACM: 2017. p. 464\u2013473."},{"issue":"15","key":"2839_CR38","doi-asserted-by":"publisher","first-page":"6959","DOI":"10.1063\/1.1505860","volume":"117","author":"EL Haseltine","year":"2002","unstructured":"Haseltine EL, Rawlings JB. Approximate simulation of coupled fast and slow reactions for stochastic chemical kinetics. J Chem Phys. 2002; 117(15):6959\u201369.","journal-title":"J Chem Phys"},{"issue":"4","key":"2839_CR39","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1063\/1.1378322","volume":"115","author":"DT Gillespie","year":"2001","unstructured":"Gillespie DT. Approximate accelerated stochastic simulation of chemically reacting systems. J Chem Phys. 2001; 115(4):1716\u201333.","journal-title":"J Chem Phys"},{"issue":"1","key":"2839_CR40","doi-asserted-by":"publisher","first-page":"014116","DOI":"10.1063\/1.1824902","volume":"122","author":"Y Cao","year":"2005","unstructured":"Cao Y, Gillespie DT, Petzold LR. The slow-scale stochastic simulation algorithm. J Chem Phys. 2005; 122(1):014116.","journal-title":"J Chem Phys"},{"issue":"3","key":"2839_CR41","doi-asserted-by":"publisher","first-page":"034105","DOI":"10.1063\/1.3677190","volume":"136","author":"Z Liu","year":"2012","unstructured":"Liu Z, Pu Y, Li F, Shaffer CA, Hoops S, Tyson JJ, Cao Y. Hybrid modeling and simulation of stochastic effects on progression through the eukaryotic cell cycle. J Chem Phys. 2012; 136(3):034105.","journal-title":"J Chem Phys"},{"issue":"02","key":"2839_CR42","doi-asserted-by":"publisher","first-page":"1750006","DOI":"10.1142\/S2424913017500060","volume":"02","author":"S Wang","year":"2017","unstructured":"Wang S, Chen M, Watson LT, Cao Y. Efficient implementation of the hybrid method for stochastic simulation of biochemical systems. J Micromech Mol Phys. 2017; 02(02):1750006.","journal-title":"J Micromech Mol Phys"},{"issue":"18","key":"2839_CR43","doi-asserted-by":"publisher","first-page":"10275","DOI":"10.1073\/pnas.1833999100","volume":"100","author":"TL Laabs","year":"2003","unstructured":"Laabs TL, Markwardt DD, Slattery MG, Newcomb LL, Stillman DJ, Heideman W. Ace2 is required for daughter cell-specific g1 delay in saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2003; 100(18):10275\u201380.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"405","key":"2839_CR44","first-page":"1","volume":"6","author":"D Barik","year":"2010","unstructured":"Barik D, Baumann WT, Paul MR, Novak B, Tyson JJ. A model of yeast cell-cycle regulation based on multisite phosphorylation. Mol Syst Biol. 2010; 6(405):1\u201318.","journal-title":"Mol Syst Biol"},{"key":"2839_CR45","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1101\/gad.11.19.2522","volume":"11","author":"M Polymenis","year":"1997","unstructured":"Polymenis M, Schmidt EV. Coupling cell division to cell growth by translational control of the g1 cyclin cln3 in yeast. Genes Dev. 1997; 11:2522\u201331.","journal-title":"Genes Dev"},{"key":"2839_CR46","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1128\/MCB.22.5.1607-1614.2002","volume":"22","author":"LL Newcomb","year":"2002","unstructured":"Newcomb LL, Hall DD, Heideman W. Azf1 is a glucose-dependent positive regulator of cln3 transcription in saccharomyces cerevisiae. Mol Cell Biol. 2002; 22:1607\u201314.","journal-title":"Mol Cell Biol"},{"key":"2839_CR47","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/251385a0","volume":"251","author":"HF Lodish","year":"1974","unstructured":"Lodish HF. Model for the regulation of mrna translation applied to haemoglobin synthesis. Nature. 1974; 251:385\u201388.","journal-title":"Nature"},{"issue":"15016","key":"2839_CR48","first-page":"1","volume":"1","author":"P Kraikivski","year":"2015","unstructured":"Kraikivski P, Chen KC, Laomettachit T, Murali T, Tyson JJ. From start to finish: computational analysis of cell cycle control in budding yeast. Syst Biol Appl. 2015; 1(15016):1\u20139.","journal-title":"Syst Biol Appl"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-2839-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-019-2839-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-2839-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T13:24:31Z","timestamp":1596115471000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-019-2839-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":48,"journal-issue":{"issue":"S12","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["2839"],"URL":"https:\/\/doi.org\/10.1186\/s12859-019-2839-9","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"20 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"322"}}