{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:34:26Z","timestamp":1763105666045,"version":"3.37.3"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","award":["IOS 1546858"],"award-info":[{"award-number":["IOS 1546858"]}],"id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12859-019-3023-y","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:03:03Z","timestamp":1566910983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["fagin: synteny-based phylostratigraphy and finer classification of young genes"],"prefix":"10.1186","volume":"20","author":[{"given":"Zebulun","family":"Arendsee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urminder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Bhandary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Seetharam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-9495","authenticated-orcid":false,"given":"Eve Syrkin","family":"Wurtele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"issue":"4295","key":"3023_CR1","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1126\/science.860134","volume":"196","author":"F Jacob","year":"1977","unstructured":"Jacob F. Evolution and tinkering. Science. 1977;196(4295):1161\u20136.","journal-title":"Science"},{"key":"3023_CR2","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/bioinformatics\/15.9.759","volume":"15","author":"D Fischer","year":"1999","unstructured":"Fischer D, Eisenberg D. Finding families for genomic ORFans. Bioinformatics (Oxford). 1999;15:759\u201362.","journal-title":"Bioinformatics (Oxford)"},{"key":"3023_CR3","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1073\/pnas.94.8.3811","volume":"94","author":"L Chen","year":"1997","unstructured":"Chen L, et al. Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc Natl Acad Sci. 1997;94:3811\u20136.","journal-title":"Proc Natl Acad Sci"},{"key":"3023_CR4","first-page":"07744","volume":"1507","author":"J Ruiz-Orera","year":"2015","unstructured":"Ruiz-Orera J, et al. Origins of de novo genes in human and chimpanzee. arXiv preprint arXiv. 2015;1507:07744.","journal-title":"arXiv preprint arXiv"},{"key":"3023_CR5","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1126\/science.1248286","volume":"343","author":"L Zhao","year":"2014","unstructured":"Zhao L, et al. Origin and spread of de novo genes in Drosophila melanogaster populations. Science. 2014;343:769\u201372.","journal-title":"Science"},{"key":"3023_CR6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1471-2164-14-117","volume":"14","author":"R Neme","year":"2013","unstructured":"Neme R, Tautz D. Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution. BMC Genomics. 2013;14:117.","journal-title":"BMC Genomics"},{"key":"3023_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1471-2148-11-47","volume":"11","author":"MT Donoghue","year":"2011","unstructured":"Donoghue MT, et al. Evolutionary origins of brassicaceae specific genes in Arabidopsis thaliana. BMC Evol Biol. 2011;11:47.","journal-title":"BMC Evol Biol"},{"key":"3023_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.febslet.2011.01.017","volume":"585","author":"Z Yang","year":"2011","unstructured":"Yang Z, Huang J. De novo origin of new genes with introns in Plasmodium vivax. FEBS Lett. 2011;585:641\u20134.","journal-title":"FEBS Lett"},{"key":"3023_CR9","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nature11184","volume":"487","author":"AR Carvunis","year":"2012","unstructured":"Carvunis AR, et al. Proto-genes and de novo gene birth. Nature. 2012;487:370\u20134.","journal-title":"Nature"},{"key":"3023_CR10","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nrg3053","volume":"12","author":"D Tautz","year":"2011","unstructured":"Tautz D, Domazet-L\u01d2so T. The evolutionary origin of orphan genes. Nat Rev Genet. 2011;12:692\u2013702.","journal-title":"Nat Rev Genet"},{"key":"3023_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.plantsci.2017.10.014","volume":"267","author":"Priyanka Bhandary","year":"2018","unstructured":"Bhandary P, et al. Raising orphans from a metadata morass: a researcher\u2019s guide to re-use of public \u2018omics data. Plant Sci. 2017;267:32\u201347.","journal-title":"Plant Science"},{"key":"3023_CR12","unstructured":"Qi M, et al. QQS orphan gene and its interactor NF-YC 4 reduce susceptibility to pathogens and pests. Plant Biotechnol J. 2018."},{"issue":"5","key":"3023_CR13","doi-asserted-by":"publisher","first-page":"e20392","DOI":"10.1371\/journal.pone.0020392","volume":"6","author":"Christian R. Voolstra","year":"2011","unstructured":"Voolstra CR, et al. Rapid evolution of coral proteins responsible for interaction with the environment PLoS One. 2011;6:e20392, e20392.","journal-title":"PLoS ONE"},{"key":"3023_CR14","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1126\/science.1197761","volume":"331","author":"JK Colbourne","year":"2011","unstructured":"Colbourne JK, et al. The ecoresponsive genome of Daphnia pulex. Science. 2011;331:555\u201361.","journal-title":"Science"},{"key":"3023_CR15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1365-313X.2009.03793.x","volume":"58","author":"L Li","year":"2009","unstructured":"Li L, et al. Identification of the novel protein QQS as a component of the starch metabolic network in Arabidopsis leaves. Plant J. 2009;58:485\u201398.","journal-title":"Plant J"},{"key":"3023_CR16","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.tig.2009.07.006","volume":"25","author":"K Khalturin","year":"2009","unstructured":"Khalturin K, et al. More than just orphans: are taxonomically-restricted genes important in evolution? Trends Genet. 2009;25:404\u201313.","journal-title":"Trends Genet"},{"key":"3023_CR17","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/1471-2164-12-164","volume":"12","author":"BR Johnson","year":"2011","unstructured":"Johnson BR, Tsutsui ND. Taxonomically restricted genes are associated with the evolution of sociality in the honey bee. BMC Genomics. 2011;12:164.","journal-title":"BMC Genomics"},{"key":"3023_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jcz.2015.03.005","volume":"256","author":"C Andrikou","year":"2015","unstructured":"Andrikou C, Arnone MI. Too many ways to make a muscle: evolution of GRNs governing myogenesis. Zool Anz J Comp Zool. 2015;256:2\u201313.","journal-title":"Zool Anz J Comp Zool"},{"key":"3023_CR19","doi-asserted-by":"publisher","first-page":"e38656","DOI":"10.1371\/journal.pone.0038656","volume":"7","author":"I Tomalova","year":"2012","unstructured":"Tomalova I, et al. The map-1 gene family in root-knot nematodes, Meloidogyne spp.: a set of taxonomically restricted genes specific to clonal species. PLoS One. 2012;7:e38656.","journal-title":"PLoS One"},{"key":"3023_CR20","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/nature08027","volume":"459","author":"MJ Wheeler","year":"2009","unstructured":"Wheeler MJ, et al. Identification of the pollen self-incompatibility determinant in Papaver rhoeas. Nature. 2009;459:992.","journal-title":"Nature"},{"issue":"2","key":"3023_CR21","doi-asserted-by":"publisher","first-page":"e4603","DOI":"10.1371\/journal.pone.0004603","volume":"4","author":"Wenfei Xiao","year":"2009","unstructured":"Xiao W, et al. A rice gene of de novo origin negatively regulates pathogen-induced defense response. PLoS One 2009;4:e4603, e4603.","journal-title":"PLoS ONE"},{"key":"3023_CR22","unstructured":"Kohler A, et al. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists. Nat Genet. 2015."},{"key":"3023_CR23","doi-asserted-by":"publisher","first-page":"20121952","DOI":"10.1098\/rspb.2012.1952","volume":"280","author":"S Shigenobu","year":"2012","unstructured":"Shigenobu S, Stern DL. Aphids evolved novel secreted proteins for symbiosis with bacterial endosymbiont. Proc R Soc B Biol Sci. 2012;280:20121952.","journal-title":"Proc R Soc B Biol Sci"},{"key":"3023_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/pbi.12238","volume":"13","author":"L Li","year":"2015","unstructured":"Li L, Wurtele ES. The QQS orphan gene of Arabidopsis modulates carbon and nitrogen allocation in soybean. Plant Biotechnol J. 2015;13:177\u201387.","journal-title":"Plant Biotechnol J"},{"key":"3023_CR25","doi-asserted-by":"crossref","unstructured":"Xie C, et al. Studying the dawn of de novo gene emergence in mice reveals fast integration of new genes into functional networks. bioRxiv. 2019:510214.","DOI":"10.1101\/510214"},{"key":"3023_CR26","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.1073\/pnas.89.12.5393","volume":"89","author":"KR Oldenburg","year":"1992","unstructured":"Oldenburg KR, et al. Peptide ligands for a sugar-binding protein isolated from a random peptide library. Proc Natl Acad Sci. 1992;89:5393\u20137.","journal-title":"Proc Natl Acad Sci"},{"key":"3023_CR27","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/35070613","volume":"410","author":"AD Keefe","year":"2001","unstructured":"Keefe AD, Szostak JW. Functional proteins from a random-sequence library. Nature. 2001;410:715.","journal-title":"Nature"},{"key":"3023_CR28","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/35015043","volume":"405","author":"SR Whaley","year":"2000","unstructured":"Whaley SR, et al. Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly. Nature. 2000;405:665.","journal-title":"Nature"},{"key":"3023_CR29","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nsmb745","volume":"11","author":"PL Surdo","year":"2004","unstructured":"Surdo PL, et al. A novel adp-and zinc-binding fold from function-directed in vitro evolution. Nat Struct Mol Biol. 2004;11:382.","journal-title":"Nat Struct Mol Biol"},{"key":"3023_CR30","doi-asserted-by":"publisher","first-page":"0127","DOI":"10.1038\/s41559-017-0127","volume":"1","author":"R Neme","year":"2017","unstructured":"Neme R, et al. Random sequences are an abundant source of bioactive RNAs or peptides. Nat Ecol Evol. 2017;1:0127.","journal-title":"Nat Ecol Evol"},{"key":"3023_CR31","doi-asserted-by":"crossref","unstructured":"Bao Z, et al. Identification of novel growth regulators in plant populations expressing random peptides. Plant Physiol. 2017;175:619\u201327.","DOI":"10.1104\/pp.17.00577"},{"key":"3023_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.tig.2007.08.014","volume":"23","author":"T Domazet-L\u01d2so","year":"2007","unstructured":"Domazet-L\u01d2so T, et al. A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages. Trends Genet. 2007;23:533\u20139.","journal-title":"Trends Genet"},{"key":"3023_CR33","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/molbev\/msu319","volume":"32","author":"MS \u0160estak","year":"2015","unstructured":"\u0160estak MS, Domazet-Loso T. Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain. Mol Biol Evol. 2015;32:299\u2013312.","journal-title":"Mol Biol Evol"},{"key":"3023_CR34","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1741-7007-8-66","volume":"8","author":"T Domazet-Loso","year":"2010","unstructured":"Domazet-Loso T, Tautz D. Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa. BMC Biol. 2010;8:66.","journal-title":"BMC Biol"},{"key":"3023_CR35","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/gbe\/evz008","volume":"11","author":"A Jain","year":"2019","unstructured":"Jain A, et al. The evolutionary traceability of a protein. Genome Biol Evol. 2019;11:531\u201345.","journal-title":"Genome Biol Evol"},{"key":"3023_CR36","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/molbev\/msu286","volume":"32","author":"BA Moyers","year":"2014","unstructured":"Moyers BA, Zhang J. Phylostratigraphic bias creates spurious patterns of genome evolution. Mol Biol Evol. 2014;32:258\u201367.","journal-title":"Mol Biol Evol"},{"key":"3023_CR37","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1101\/gr.095026.109","volume":"19","author":"DG Knowles","year":"2009","unstructured":"Knowles DG, McLysaght A. Recent de novo origin of human protein-coding genes. Genome Res. 2009;19:1752\u20139.","journal-title":"Genome Res"},{"key":"3023_CR38","first-page":"2906","volume":"10","author":"C Casola","year":"2018","unstructured":"Casola C. From de novo to \u201cde nono\u201d: the majority of novel protein-coding genes identified with phylostratigraphy are old genes or recent duplicates. Genome Biol Evol. 2018;10:2906\u201318.","journal-title":"Genome Biol Evol"},{"key":"3023_CR39","first-page":"63","volume-title":"Computational prediction of De novo emerged protein-coding genes","author":"N Vakirlis","year":"2019","unstructured":"Vakirlis N, McLysaght A. Computational prediction of De novo emerged protein-coding genes. New York: Springer; 2019. p. 63\u201381."},{"key":"3023_CR40","doi-asserted-by":"crossref","unstructured":"Arendsee Z, et al. Synder: inferring genomic orthologs from synteny maps. bioRxiv. 2019.","DOI":"10.1101\/554501"},{"key":"3023_CR41","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/gb-2005-6-5-r44","volume":"6","author":"K Eilbeck","year":"2005","unstructured":"Eilbeck K, et al. The sequence ontology: a tool for the unification of genome annotations. Genome Biol. 2005;6:R44.","journal-title":"Genome Biol"},{"key":"3023_CR42","unstructured":"Tjeldnes H, Labun K. ORFik: Open Reading Frames in Genomics. R package version 1.4.1; 2019."},{"key":"3023_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1101\/gr.809403","volume":"13","author":"S Schwartz","year":"2003","unstructured":"Schwartz S, et al. Human-mouse alignments with BLASTZ. Genome Res. 2003;13:103\u20137.","journal-title":"Genome Res"},{"issue":"4","key":"3023_CR44","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1093\/nar\/gkq1212","volume":"39","author":"Martin C. Frith","year":"2010","unstructured":"Frith MC. A new repeat-masking method enables specific detection of homologous sequences. Nucleic Acids Res. 2010;39:e23.","journal-title":"Nucleic Acids Research"},{"key":"3023_CR45","doi-asserted-by":"crossref","unstructured":"Barrodale I, Roberts FD. An improved algorithm for discrete l 1 linear approximation. SIAM J Numer Anal. 1973;10:839\u201348.","DOI":"10.1137\/0710069"},{"key":"3023_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v064.i04","volume":"64","author":"ML Delignette-Muller","year":"2015","unstructured":"Delignette-Muller ML, Dutang C. Fitdistrplus: an R package for fitting distributions. J Stat Softw. 2015;64:1\u201334.","journal-title":"J Stat Softw"},{"key":"3023_CR47","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5:R80.","journal-title":"Genome Biol"},{"key":"3023_CR48","doi-asserted-by":"publisher","first-page":"e1005944","DOI":"10.1371\/journal.pcbi.1005944","volume":"14","author":"G Mar\u00e7ais","year":"2018","unstructured":"Mar\u00e7ais G, et al. MUMmer4: a fast and versatile genome alignment system. PLoS Comput Biol. 2018;14:e1005944.","journal-title":"PLoS Comput Biol"},{"key":"3023_CR49","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1093\/bioinformatics\/btq102","volume":"26","author":"MG Grabherr","year":"2010","unstructured":"Grabherr MG, et al. Genome-wide synteny through highly sensitive sequencealignment: Satsuma. Bioinformatics. 2010;26:1145\u201351.","journal-title":"Bioinformatics"},{"key":"3023_CR50","doi-asserted-by":"crossref","unstructured":"Arendsee Z, et al. Phylostratr: a framework for phylostratigraphy. Bioinformatics. 2019; btz171.","DOI":"10.1101\/360164"},{"key":"3023_CR51","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.tplants.2014.07.003","volume":"19","author":"ZW Arendsee","year":"2014","unstructured":"Arendsee ZW, et al. Coming of age: orphan genes in plants. Trends Plant Sci. 2014;19:698\u2013708.","journal-title":"Trends Plant Sci"},{"key":"3023_CR52","first-page":"46","volume":"4","author":"R Yang","year":"2013","unstructured":"Yang R, et al. The reference genome of the halophytic plant Eutrema salsug-ineum. Front Plant Sci. 2013;4:46.","journal-title":"Front Plant Sci"},{"key":"3023_CR53","doi-asserted-by":"crossref","unstructured":"Shen XX, et al. Reconstructing the backbone of the Saccharomycotina yeast phylogeny using genome-scale data. G3: Genes, Genomes, Genet. 2016:g3\u2013116.","DOI":"10.1101\/070235"},{"key":"3023_CR54","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.1073\/pnas.1817138116","volume":"116","author":"X Zhuang","year":"2019","unstructured":"Zhuang X, et al. Molecular mechanism and history of non-sense to sense evolution of antifreeze glycoprotein gene in northern gadids. Proc Natl Acad Sci. 2019;116:4400\u20135.","journal-title":"Proc Natl Acad Sci"},{"key":"3023_CR55","doi-asserted-by":"publisher","first-page":"10719","DOI":"10.1128\/JVI.00595-09","volume":"83","author":"C Rancurel","year":"2009","unstructured":"Rancurel C, et al. Overlapping genes produce proteins with unusual sequence properties and offer insight into de novo protein creation. J Virol. 2009;83:10719\u201336.","journal-title":"J Virol"},{"key":"3023_CR56","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1093\/molbev\/mss179","volume":"29","author":"N Sabath","year":"2012","unstructured":"Sabath N, et al. Evolution of viral proteins originated de novo by overprinting. Mol Biol Evol. 2012;29:3767\u201380.","journal-title":"Mol Biol Evol"},{"issue":"5","key":"3023_CR57","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1371\/journal.pcbi.0030091","volume":"3","author":"Wen-Yu Chung","year":"2007","unstructured":"Chung WY, et al. A first look at ARFome: dual-coding genes in mammalian genomes. PLoS Comput Biol. 2007;3:e91, e91.","journal-title":"PLoS Computational Biology"},{"key":"3023_CR58","doi-asserted-by":"publisher","first-page":"D700","DOI":"10.1093\/nar\/gkr1029","volume":"40","author":"JM Cherry","year":"2011","unstructured":"Cherry JM, et al. Saccharomyces genome database: the genomics resource of budding yeast. Nucleic Acids Res. 2011;40:D700\u20135.","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-3023-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12859-019-3023-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-019-3023-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T23:08:04Z","timestamp":1598396884000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-019-3023-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3023"],"URL":"https:\/\/doi.org\/10.1186\/s12859-019-3023-y","relation":{},"ISSN":["1471-2105"],"issn-type":[{"type":"electronic","value":"1471-2105"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"14 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"NA","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"440"}}