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They are located within longer intrinsically disordered regions (IDRs), and undergo disorder-to-order transitions upon binding to their interaction partners. The functional importance of MoRFs and the limitation of experimental identification make it necessary to predict MoRFs accurately with computational methods.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this study, a new sequence-based method, named as MoRF<jats:sub>MPM<\/jats:sub>, is proposed for predicting MoRFs. MoRF<jats:sub>MPM<\/jats:sub> uses minimax probability machine (MPM) to predict MoRFs based on 16 features and 3 different windows, which neither relying on other predictors nor calculating the properties of the surrounding regions of MoRFs separately. Comparing with ANCHOR, MoRFpred and MoRF<jats:sub>CHiBi<\/jats:sub> on the same test sets, MoRF<jats:sub>MPM<\/jats:sub> not only obtains higher AUC, but also obtains higher TPR at low FPR.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The features used in MoRF<jats:sub>MPM<\/jats:sub> can effectively predict MoRFs, especially after preprocessing. Besides, MoRF<jats:sub>MPM<\/jats:sub> uses a linear classification algorithm and does not rely on results of other predictors which makes it accessible and repeatable.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-019-3111-z","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T17:05:08Z","timestamp":1572282308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Computational prediction of MoRFs based on protein sequences and minimax probability machine"],"prefix":"10.1186","volume":"20","author":[{"given":"Hao","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-0811","authenticated-orcid":false,"given":"Jiaxiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"3111_CR1","doi-asserted-by":"crossref","unstructured":"Uversky VN. 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