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We compared Circle-Map to similar up-to-date methods for circular DNA and RNA detection and we demonstrate how the approach implemented in Circle-Map dramatically increases sensitivity for detection of circular DNA on both simulated and real data while retaining high precision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Circle-Map is an easy-to-use command line tool that implements the required pipeline to accurately detect circular DNA from circle enriched next generation sequencing experiments. Circle-Map is implemented in python3.6 and it is freely available at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/iprada\/Circle-Map\">https:\/\/github.com\/iprada\/Circle-Map<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12859-019-3160-3","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T12:05:02Z","timestamp":1576152302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-0726","authenticated-orcid":false,"given":"I\u00f1igo","family":"Prada-Luengo","sequence":"first","affiliation":[]},{"given":"Anders","family":"Krogh","sequence":"additional","affiliation":[]},{"given":"Lasse","family":"Maretty","sequence":"additional","affiliation":[]},{"given":"Birgitte","family":"Regenberg","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"3160_CR1","doi-asserted-by":"publisher","first-page":"E3114","DOI":"10.1073\/pnas.1508825112","volume":"112","author":"HD M\u00f8ller","year":"2015","unstructured":"M\u00f8ller HD, Parsons L, J\u00f8rgensen TS, Botstein D, Regenberg B. 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