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Shape complementarity is the most basic component of a scoring function and plays an important role in protein-protein docking. Despite significant progresses, shape representation remains an open question in the development of protein-protein docking algorithms, especially for grid-based docking approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have proposed a new pairwise shape-based scoring function (LSC) for protein-protein docking which adopts an exponential form to take into account long-range interactions between protein atoms. The LSC scoring function was incorporated into our FFT-based docking program and evaluated for both bound and unbound docking on the protein docking benchmark 4.0. It was shown that our LSC achieved a significantly better performance than four other similar docking methods, ZDOCK 2.1, MolFit\/G, GRAMM, and FTDock\/G, in both success rate and number of hits. When considering the top 10 predictions, LSC obtained a success rate of 51.71% and 6.82% for bound and unbound docking, respectively, compared to 42.61% and 4.55% for the second-best program ZDOCK 2.1. LSC also yielded an average of 8.38 and 3.94 hits per complex in the top 1000 predictions for bound and unbound docking, respectively, followed by 6.38 and 2.96 hits for the second-best ZDOCK 2.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present LSC method will not only provide an initial-stage docking approach for post-docking processes but also have a general implementation for accurate representation of other energy terms on grids in protein-protein docking. The software has been implemented in our HDOCK web server at<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/hdock.phys.hust.edu.cn\/\">http:\/\/hdock.phys.hust.edu.cn\/<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-019-3270-y","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T09:02:35Z","timestamp":1577178155000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pushing the accuracy limit of shape complementarity for protein-protein docking"],"prefix":"10.1186","volume":"20","author":[{"given":"Yumeng","family":"Yan","sequence":"first","affiliation":[]},{"given":"Sheng-You","family":"Huang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,12,24]]},"reference":[{"issue":"8","key":"3270_CR1","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.bpj.2014.08.033","volume":"107","author":"IA Vakser","year":"2014","unstructured":"Vakser IA. 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