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Then, we explore the significant correlation between <jats:italic>AEBP1<\/jats:italic> upregulation and increased <jats:italic>EGFR<\/jats:italic> expression in primary glioma, and employ a glioma cell line LN229 to identify relevant proteins and molecular pathways through protein network analysis. Finally, we identify that <jats:italic>AEBP1<\/jats:italic> exerts its tumor-promoting effects by mainly activating mTOR pathway in Glioma.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We summarize the whole process of the experiment and discuss how to expand our experiment in the future.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12859-020-03674-4","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:03:04Z","timestamp":1600300984000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Developing the novel bioinformatics algorithms to systematically investigate the connections among survival time, key genes and proteins for Glioblastoma multiforme"],"prefix":"10.1186","volume":"21","author":[{"given":"Yujie","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xufang","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiru","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"issue":"1","key":"3674_CR1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jnci.2012.11.001","volume":"25","author":"N Ahmadloo","year":"2013","unstructured":"Ahmadloo N, et al. 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