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This study aims to investigate APOE \u03b54 effects on brain connectivity from the perspective of multimodal connectome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here, we propose a novel multimodal brain network modeling framework and a network quantification method based on persistent homology for identifying APOE \u03b54-related network differences. Specifically, we employ sparse representation to integrate multimodal brain network information derived from both the resting state functional magnetic resonance imaging (rs-fMRI) data and the diffusion-weighted magnetic resonance imaging (dw-MRI) data. Moreover, persistent homology is proposed to avoid the ad hoc selection of a specific regularization parameter and to capture valuable brain connectivity patterns from the topological perspective. The experimental results demonstrate that our method outperforms the competing methods, and reasonably yields connectomic patterns specific to APOE \u03b54 carriers and non-carriers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We have proposed a multimodal framework that integrates structural and functional connectivity information for constructing a fused brain network with greater discriminative power. Using persistent homology to extract topological features from the fused brain network, our method can effectively identify APOE \u03b54-related brain connectomic biomarkers.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-020-03877-9","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T07:02:43Z","timestamp":1609138963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of APOE \u03b54 on multimodal brain connectomic traits: a persistent homology study"],"prefix":"10.1186","volume":"21","author":[{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"first","affiliation":[]},{"given":"Jin","family":"Li","sequence":"first","affiliation":[]},{"given":"Chenyuan","family":"Bian","sequence":"additional","affiliation":[]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Xianglian","family":"Meng","sequence":"additional","affiliation":[]},{"given":"Haoran","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-0503","authenticated-orcid":false,"given":"Li","family":"Shen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"key":"3877_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuroimage.2019.05.044","volume":"199","author":"BL Klaassens","year":"2019","unstructured":"Klaassens BL, et al. 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Ethics approval was obtained from the institutional review boards of each institution involved: Oregon Health and Science University; University of Southern California; University of California\u2014San Diego; University of Michigan; Mayo Clinic, Rochester; Baylor College of Medicine; Columbia University Medical Center; Washington University, St. Louis; University of Alabama at Birmingham; Mount Sinai School of Medicine; Rush University Medical Center; Wien Center; Johns Hopkins University; New York University; Duke University Medical Center; University of Pennsylvania; University of Kentucky; University of Pittsburgh; University of Rochester Medical Center; University of California, Irvine; University of Texas Southwestern Medical School; Emory University; University of Kansas, Medical Center; University of California, Los Angeles; Mayo Clinic, Jacksonville; Indiana University; Yale University School of Medicine; McGill University, Montreal-Jewish General Hospital; Sunnybrook Health Sciences, Ontario; U.B.C. Clinic for AD & Related Disorders; Cognitive Neurology\u2014St. Joseph\u2019s, Ontario; Cleveland Clinic Lou Ruvo Center for Brain Health; Northwestern University; Premiere Research Inst (Palm Beach Neurology); Georgetown University Medical Center; Brigham and Women\u2019s Hospital; Stanford University; Banner Sun Health Research Institute; Boston University; Howard University; Case Western Reserve University; University of California, Davis\u2014Sacramento; Neurological Care of CNY; Parkwood Hospital; University of Wisconsin; University of California, Irvine\u2014BIC; Banner Alzheimer\u2019s Institute; Dent Neurologic Institute; Ohio State University; Albany Medical College; Hartford Hospital, Olin Neuropsychiatry Research Center; Dartmouth-Hitchcock Medical Center; Wake Forest University Health Sciences; Rhode Island Hospital; Butler Hospital; UC San Francisco; Medical University South Carolina; St. Joseph\u2019s Health Care Nathan Kline Institute; University of Iowa College of Medicine; Cornell University; and University of South Florida: USF Health Byrd Alzheimer\u2019s Institute.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"535"}}