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This paper presents GSP4PDB, a bioinformatics web tool that enables the user to visualize, search and explore protein-ligand structural patterns within the entire Protein Data Bank.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We introduce the notion of graph-based structural pattern (GSP) as an abstract model for representing protein-ligand interactions. A GSP is a graph where the nodes represent entities of the protein-ligand complex (amino acids and ligands) and the edges represent structural relationships (e.g. distances ligand - amino acid). The novel feature of GSP4PDB is a simple and intuitive graphical interface where the user can \u201cdraw\u201d a GSP and execute its search in a relational database containing the structural data of each PDB entry. The results of the search are displayed using the same graph-based representation of the pattern. The user can further explore and analyse the results using a wide range of filters, or download their related information for external post-processing and analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>GSP4PDB is a user-friendly and efficient application to search and discover new patterns of protein-ligand interaction.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-020-3352-x","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T02:02:49Z","timestamp":1584064969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["GSP4PDB: a web tool to visualize, search and explore protein-ligand structural patterns"],"prefix":"10.1186","volume":"21","author":[{"given":"Renzo","family":"Angles","sequence":"first","affiliation":[]},{"given":"Mauricio","family":"Arenas-Salinas","sequence":"additional","affiliation":[]},{"given":"Roberto","family":"Garc\u00eda","sequence":"additional","affiliation":[]},{"given":"Jose Antonio","family":"Reyes-Suarez","sequence":"additional","affiliation":[]},{"given":"Ehmke","family":"Pohl","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"issue":"9","key":"3352_CR1","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.1021\/acs.jmedchem.6b00078","volume":"59","author":"C Ehrt","year":"2016","unstructured":"Ehrt C, Brinkjost T, Koch O. 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