{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:45:18Z","timestamp":1761745518341,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"S5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 109-2221-E-037-005","MOST 109-2221-E-153-005-MY3"],"award-info":[{"award-number":["MOST 109-2221-E-037-005","MOST 109-2221-E-153-005-MY3"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To classify chest computed tomography (CT) images as positive or negative for coronavirus disease 2019 (COVID-19) quickly and accurately, researchers attempted to develop effective models by using medical images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A convolutional neural network (CNN) ensemble model was developed for classifying chest CT images as positive or negative for COVID-19. To classify chest CT images acquired from COVID-19 patients, the proposed COVID19-CNN ensemble model combines the use of multiple trained CNN models with a majority voting strategy. The CNN models were trained to classify chest CT images by transfer learning from well-known pre-trained CNN models and by applying their algorithm hyperparameters as appropriate. The combination of algorithm hyperparameters for a pre-trained CNN model was determined by uniform experimental design. The chest CT images (405 from COVID-19 patients and 397 from healthy patients) used for training and performance testing of the COVID19-CNN ensemble model were obtained from an earlier study by Hu in 2020. Experiments showed that, the COVID19-CNN ensemble model achieved 96.7% accuracy in classifying CT images as COVID-19 positive or negative, which was superior to the accuracies obtained by the individual trained CNN models. Other performance measures (i.e., precision, recall, specificity, and F<jats:sub>1<\/jats:sub>-score) obtained bythe COVID19-CNN ensemble model were higher than those obtained by individual trained CNN models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The COVID19-CNN ensemble model had superior accuracy and excellent capability in classifying chest CT images as COVID-19 positive or negative.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-021-04083-x","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T15:05:43Z","timestamp":1636383943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Classifying chest CT images as COVID-19 positive\/negative using a convolutional neural network ensemble model and uniform experimental design method"],"prefix":"10.1186","volume":"22","author":[{"given":"Yao-Mei","family":"Chen","sequence":"first","affiliation":[]},{"given":"Yenming J.","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Wen-Hsien","family":"Ho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-5027","authenticated-orcid":false,"given":"Jinn-Tsong","family":"Tsai","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"4083_CR1","unstructured":"Gozes O, Frid-Adar M, Greenspan H, Browning P, Zhang H, Ji W, Bernheim A. Rapid AI development cycle for the coronavirus (COVID-19) pandemic: initial results for automated detection and patient monitoring using deep learning CT image analysis. Submitted to Radiology: Artificial Intelligence; 2020. p. 1\u201322."},{"key":"4083_CR2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.24.20078998","author":"R Hu","year":"2020","unstructured":"Hu R, Ruan G, Xiang S, Huang M, Liang Q, Li J. Automated diagnosis of COVID-19 using deep learning and data augmentation on chest CT. Medrxiv. 2020. https:\/\/doi.org\/10.1101\/2020.04.24.20078998.","journal-title":"Medrxiv"},{"key":"4083_CR3","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200905","author":"L Li","year":"2020","unstructured":"Li L, Qin L, Xu Z, Yin Y, Wang X, Kong B, Bai J, Lu Y, Fang Z, Song Q, Cao K, Liu D, Wang G, Xu Q, Fang X, Zhang S, Xia J, Xia J. Artificial intelligence distinguishes COVID-19 from community acquired pneumonia on chest CT. 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