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However, studies integrating nucleosome organization in mammalian genomes are very limited mainly due to the lack of comprehensive data quality control (QC) assessment and uneven data quality of public data sets.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The <jats:italic>NUCOME<\/jats:italic> is a database focused on filtering qualified nucleosome organization referenced landscapes covering various cell types in human and mouse based on QC metrics. The filtering strategy guarantees the quality of nucleosome organization referenced landscapes and exempts users from redundant data set selection and processing. The <jats:italic>NUCOME<\/jats:italic> database provides standardized, qualified data source and informative nucleosome organization features at a whole-genome scale and on the level of individual loci.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The <jats:italic>NUCOME<\/jats:italic> provides valuable data resources for integrative analyses focus on nucleosome organization. The <jats:italic>NUCOME<\/jats:italic> is freely available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/compbio-zhanglab.org\/NUCOME\">http:\/\/compbio-zhanglab.org\/NUCOME<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-021-04239-9","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T21:02:27Z","timestamp":1623618147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NUCOME: A comprehensive database of nucleosome organization referenced landscapes in mammalian genomes"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaolan","family":"Chen","sequence":"first","affiliation":[]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Guifen","family":"Liu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-2734","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"4239_CR1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nrm.2017.47","volume":"18","author":"WKM Lai","year":"2017","unstructured":"Lai WKM, Pugh BF. 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