{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T17:23:45Z","timestamp":1770571425997,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"S10","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":75,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-109-2636-B- 002 -001"],"award-info":[{"award-number":["MOST-109-2636-B- 002 -001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-108-2636-B- 002 -001"],"award-info":[{"award-number":["MOST-108-2636-B- 002 -001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mitochondria play essential roles in regulating cellular functions. Some drug treatments and molecular interventions have been reported to have off-target effects damaging mitochondria and causing severe side effects. The development of a database for the management of mitochondrial toxicity-related molecules and their targets is important for further analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>To correlate chemical, biological and mechanistic information on clinically relevant mitochondria-related toxicity, a comprehensive mitochondrial toxicity database (MitoTox) was developed. MitoTox is an electronic repository that integrates comprehensive information about mitochondria-related toxins and their targets. Information and data related to mitochondrial toxicity originate from various sources, including scientific journals and other electronic databases. These resources were manually verified and extracted into MitoTox. The database currently contains over 1400 small-molecule compounds, 870 mitochondrial targets, and more than 4100 \u00a0mitochondrial\u00a0toxin-target associations. Each MitoTox data record contains over 30 fields, including biochemical properties, therapeutic classification, target proteins, toxicological data, mechanistic information, clinical side effects, and references.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MitoTox provides a fully searchable database with links to references and other databases. Potential applications of MitoTox include toxicity classification, prediction, reference and education. MitoTox is available online at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mitotox.org\">http:\/\/www.mitotox.org<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-021-04285-3","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T13:02:59Z","timestamp":1626354179000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["MitoTox: a comprehensive mitochondrial toxicity database"],"prefix":"10.1186","volume":"22","author":[{"given":"Yu-Te","family":"Lin","sequence":"first","affiliation":[]},{"given":"Ko-Hong","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Chi-Jung","family":"Huang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-1636","authenticated-orcid":false,"given":"An-Chi","family":"Wei","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"4285_CR1","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1126\/science.aax3768","volume":"366","author":"A Mottis","year":"2019","unstructured":"Mottis A, Herzig S, Auwerx J. Mitocellular communication: shaping health and disease. Science. 2019;366:827\u201332. https:\/\/doi.org\/10.1126\/science.aax3768.","journal-title":"Science"},{"key":"4285_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.beem.2012.05.003","volume":"26","author":"LD Osellame","year":"2012","unstructured":"Osellame LD, Blacker TS, Duchen MR. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab. 2012;26:711\u201323. https:\/\/doi.org\/10.1016\/j.beem.2012.05.003.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"4285_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymgme.2006.05.015","volume":"89","author":"BH Robinson","year":"2006","unstructured":"Robinson BH. Lactic acidemia and mitochondrial disease. Mol Genet Metab. 2006;89:3\u201313. https:\/\/doi.org\/10.1016\/j.ymgme.2006.05.015.","journal-title":"Mol Genet Metab"},{"key":"4285_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10545-010-9082-x","volume":"34","author":"S Dimauro","year":"2011","unstructured":"Dimauro S. A history of mitochondrial diseases. J Inherit Metab Dis. 2011;34:261\u201376. https:\/\/doi.org\/10.1007\/s10545-010-9082-x.","journal-title":"J Inherit Metab Dis"},{"key":"4285_CR5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","volume":"15","author":"DC Chan","year":"2020","unstructured":"Chan DC. Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol. 2020;15:235\u201359. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012419-032711.","journal-title":"Annu Rev Pathol"},{"key":"4285_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/0471140856.tx0215s40","author":"S Nadanaciva","year":"2009","unstructured":"Nadanaciva S, Will Y. Current concepts in drug-induced mitochondrial toxicity. Curr Protoc Toxicol. 2009. https:\/\/doi.org\/10.1002\/0471140856.tx0215s40.","journal-title":"Curr Protoc Toxicol"},{"key":"4285_CR7","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1517\/17425255.1.4.655","volume":"1","author":"K Chan","year":"2005","unstructured":"Chan K, Truong D, Shangari N, O\u2019Brien PJ. Drug-induced mitochondrial toxicity. Expert Opin Drug Metab Toxicol. 2005;1:655\u201369. https:\/\/doi.org\/10.1517\/17425255.1.4.655.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4285_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2017.08.005","volume":"391","author":"KB Wallace","year":"2017","unstructured":"Wallace KB. Mitochondrial toxicity. Toxicology. 2017;391:1. https:\/\/doi.org\/10.1016\/j.tox.2017.08.005.","journal-title":"Toxicology"},{"key":"4285_CR9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1146\/annurev.pharmtox.40.1.353","volume":"40","author":"KB Wallace","year":"2000","unstructured":"Wallace KB, Starkov AA. Mitochondrial targets of drug toxicity. Annu Rev Pharmacol Toxicol. 2000;40:353\u201388. https:\/\/doi.org\/10.1146\/annurev.pharmtox.40.1.353.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"4285_CR10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.drudis.2007.07.013","volume":"12","author":"JA Dykens","year":"2007","unstructured":"Dykens JA, Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Discov Today. 2007;12:777\u201385. https:\/\/doi.org\/10.1016\/j.drudis.2007.07.013.","journal-title":"Drug Discov Today"},{"key":"4285_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mito.2016.10.005","volume":"31","author":"M Vuda","year":"2016","unstructured":"Vuda M, Kamath A. Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences. Mitochondrion. 2016;31:63\u201374. https:\/\/doi.org\/10.1016\/j.mito.2016.10.005.","journal-title":"Mitochondrion"},{"key":"4285_CR12","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1517\/17425255.2014.939628","volume":"10","author":"Y Will","year":"2014","unstructured":"Will Y, Dykens J. Mitochondrial toxicity assessment in industry\u2014a decade of technology development and insight. Expert Opin Drug Metab Toxicol. 2014;10:1061\u20137. https:\/\/doi.org\/10.1517\/17425255.2014.939628.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4285_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cmet.2015.08.002","volume":"22","author":"TJJ Schirris","year":"2015","unstructured":"Schirris TJJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BGM, et al. Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab. 2015;22:399\u2013407. https:\/\/doi.org\/10.1016\/j.cmet.2015.08.002.","journal-title":"Cell Metab"},{"key":"4285_CR14","doi-asserted-by":"publisher","first-page":"256","DOI":"10.21037\/atm.2018.06.21","volume":"6","author":"G Siasos","year":"2018","unstructured":"Siasos G, Tsigkou V, Kosmopoulos M, Theodosiadis D, Simantiris S, Tagkou NM, et al. Mitochondria and cardiovascular diseases-from pathophysiology to treatment. Ann Transl Med. 2018;6:256. https:\/\/doi.org\/10.21037\/atm.2018.06.21.","journal-title":"Ann Transl Med"},{"key":"4285_CR15","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.2174\/138161211796904812","volume":"17","author":"GC Pereira","year":"2011","unstructured":"Pereira GC, Silva AM, Diogo CV, Carvalho FS, Monteiro P, Oliveira PJ. Drug-induced cardiac mitochondrial toxicity and protection: from doxorubicin to carvedilol. Curr Pharm Des. 2011;17:2113\u201329. https:\/\/doi.org\/10.2174\/138161211796904812.","journal-title":"Curr Pharm Des"},{"key":"4285_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/toxsci\/kft102","volume":"134","author":"JN Meyer","year":"2013","unstructured":"Meyer JN, Leung MCK, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134:1\u201317. https:\/\/doi.org\/10.1093\/toxsci\/kft102.","journal-title":"Toxicol Sci"},{"key":"4285_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tox.2017.07.009","volume":"391","author":"Z Zolkipli-Cunningham","year":"2017","unstructured":"Zolkipli-Cunningham Z, Falk MJ. Clinical effects of chemical exposures on mitochondrial function. Toxicology. 2017;391:90\u20139. https:\/\/doi.org\/10.1016\/j.tox.2017.07.009.","journal-title":"Toxicology"},{"key":"4285_CR18","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1021\/acs.chemrestox.5b00275","volume":"28","author":"MD Nelms","year":"2015","unstructured":"Nelms MD, Mellor CL, Cronin MTD, Madden JC, Enoch SJ. Development of an in silico profiler for mitochondrial toxicity. Chem Res Toxicol. 2015;28:1891\u2013902. https:\/\/doi.org\/10.1021\/acs.chemrestox.5b00275.","journal-title":"Chem Res Toxicol"},{"key":"4285_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1289\/ehp.1408642","volume":"123","author":"MS Attene-Ramos","year":"2015","unstructured":"Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, et al. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect. 2015;123:49\u201356. https:\/\/doi.org\/10.1289\/ehp.1408642.","journal-title":"Environ Health Perspect"},{"key":"4285_CR20","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1021\/tx4001754","volume":"26","author":"MS Attene-Ramos","year":"2013","unstructured":"Attene-Ramos MS, Huang R, Sakamuru S, Witt KL, Beeson GC, Shou L, et al. Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. Chem Res Toxicol. 2013;26:1323\u201332. https:\/\/doi.org\/10.1021\/tx4001754.","journal-title":"Chem Res Toxicol"},{"key":"4285_CR21","doi-asserted-by":"publisher","DOI":"10.1289\/EHP2589","volume":"126","author":"M Xia","year":"2018","unstructured":"Xia M, Huang R, Shi Q, Boyd WA, Zhao J, Sun N, et al. Comprehensive analyses and prioritization of Tox21 10K chemicals affecting mitochondrial function by in-depth mechanistic studies. Environ Health Perspect. 2018;126: 077010. https:\/\/doi.org\/10.1289\/EHP2589.","journal-title":"Environ Health Perspect"},{"key":"4285_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.taap.2007.12.037","volume":"233","author":"R Judson","year":"2008","unstructured":"Judson R, Richard A, Dix D, Houck K, Elloumi F, Martin M, et al. ACToR\u2013Aggregated computational toxicology resource. Toxicol Appl Pharmacol. 2008;233:7\u201313. https:\/\/doi.org\/10.1016\/j.taap.2007.12.037.","journal-title":"Toxicol Appl Pharmacol"},{"key":"4285_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp934","author":"E Lim","year":"2010","unstructured":"Lim E, Pon A, Djoumbou Y, Knox C, Shrivastava S, Guo AC, et al. T3DB: a comprehensively annotated database of common toxins and their targets. Nucleic Acids Res. 2010. https:\/\/doi.org\/10.1093\/nar\/gkp934.","journal-title":"Nucleic Acids Res"},{"key":"4285_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn580","author":"AP Davis","year":"2009","unstructured":"Davis AP, Murphy CG, Saraceni-Richards CA, Rosenstein MC, Wiegers TC, Mattingly CJ. Comparative toxicogenomics database: a knowledgebase and discovery tool for chemical-gene-disease networks. Nucleic Acids Res. 2009. https:\/\/doi.org\/10.1093\/nar\/gkn580.","journal-title":"Nucleic Acids Res"},{"key":"4285_CR25","doi-asserted-by":"publisher","first-page":"A23","DOI":"10.1289\/ehp.123-A23","volume":"123","author":"C Potera","year":"2015","unstructured":"Potera C. Potential mitochondrial toxicants: Tox21 screen identifies structures of interest. Environ Health Perspect. 2015;123:A23. https:\/\/doi.org\/10.1289\/ehp.123-A23.","journal-title":"Environ Health Perspect"},{"key":"4285_CR26","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, et al. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018;46:D1074\u201382. https:\/\/doi.org\/10.1093\/nar\/gkx1037.","journal-title":"Nucleic Acids Res"},{"key":"4285_CR27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer A, Green J, Pollard J, Tugendreich S. Causal analysis approaches in ingenuity pathway analysis. Bioinformatics. 2014;30:523\u201330. https:\/\/doi.org\/10.1093\/bioinformatics\/btt703.","journal-title":"Bioinformatics"},{"key":"4285_CR28","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1586\/14737159.7.2.161","volume":"7","author":"JA Dykens","year":"2007","unstructured":"Dykens JA, Marroquin LD, Will Y. Strategies to reduce late-stage drug attrition due to mitochondrial toxicity. Expert Rev Mol Diagn. 2007;7:161\u201375. https:\/\/doi.org\/10.1586\/14737159.7.2.161.","journal-title":"Expert Rev Mol Diagn"},{"key":"4285_CR29","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.2174\/0929867322666150514095424","volume":"22","author":"KB Wallace","year":"2015","unstructured":"Wallace KB. Multiple targets for drug-induced mitochondrial toxicity. Curr Med Chem. 2015;22:2488\u201392. https:\/\/doi.org\/10.2174\/0929867322666150514095424.","journal-title":"Curr Med Chem"},{"key":"4285_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/0471140856.tx0220s49","author":"R Swiss","year":"2011","unstructured":"Swiss R, Will Y. Assessment of mitochondrial toxicity in HepG2 cells cultured in high-glucose- or galactose-containing media. Curr Protoc Toxicol. 2011. https:\/\/doi.org\/10.1002\/0471140856.tx0220s49.","journal-title":"Curr Protoc Toxicol"},{"key":"4285_CR31","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1089\/ars.2012.4886","volume":"20","author":"SI Dikalov","year":"2014","unstructured":"Dikalov SI, Harrison DG. Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid Redox Signal. 2014;20:372\u201382. https:\/\/doi.org\/10.1089\/ars.2012.4886.","journal-title":"Antioxid Redox Signal"},{"key":"4285_CR32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-3-319-28549-8_6","volume":"219","author":"T Sieprath","year":"2016","unstructured":"Sieprath T, Corne TDJ, Willems PHGM, Koopman WJH, De Vos WH. Integrated high-content quantification of intracellular ROS levels and mitochondrial morphofunction. Adv Anat Embryol Cell Biol. 2016;219:149\u201377. https:\/\/doi.org\/10.1007\/978-3-319-28549-8_6.","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"4285_CR33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1152\/physiolgenomics.00161.2011","volume":"44","author":"S Sakamuru","year":"2012","unstructured":"Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, et al. Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol Genomics. 2012;44:495\u2013503. https:\/\/doi.org\/10.1152\/physiolgenomics.00161.2011.","journal-title":"Physiol Genomics"},{"issue":"1 Pt 1","key":"4285_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","volume":"76","author":"RC Scaduto","year":"1999","unstructured":"Scaduto RC, Grotyohann LW. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J. 1999;76(1 Pt 1):469\u201377. https:\/\/doi.org\/10.1016\/S0006-3495(99)77214-0.","journal-title":"Biophys J"},{"key":"4285_CR35","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.bbabio.2016.02.016","volume":"1857","author":"J \u0160ileikyt\u0117","year":"2016","unstructured":"\u0160ileikyt\u0117 J, Forte M. Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition. Biochim Biophys Acta. 2016;1857:1197\u2013202. https:\/\/doi.org\/10.1016\/j.bbabio.2016.02.016.","journal-title":"Biochim Biophys Acta"},{"key":"4285_CR36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.tiv.2016.03.016","volume":"34","author":"J Eakins","year":"2016","unstructured":"Eakins J, Bauch C, Woodhouse H, Park B, Bevan S, Dilworth C, et al. A combined in vitro approach to improve the prediction of mitochondrial toxicants. Toxicol In Vitro. 2016;34:161\u201370. https:\/\/doi.org\/10.1016\/j.tiv.2016.03.016.","journal-title":"Toxicol In Vitro"},{"key":"4285_CR37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/BJ20110162","volume":"435","author":"MD Brand","year":"2011","unstructured":"Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011;435:297\u2013312. https:\/\/doi.org\/10.1042\/BJ20110162.","journal-title":"Biochem J"},{"key":"4285_CR38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.tox.2017.07.020","volume":"391","author":"LP Wills","year":"2017","unstructured":"Wills LP. The use of high-throughput screening techniques to evaluate mitochondrial toxicity. Toxicology. 2017;391:34\u201341. https:\/\/doi.org\/10.1016\/j.tox.2017.07.020.","journal-title":"Toxicology"},{"key":"4285_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.rbmo.2014.03.002","volume":"29","author":"KH Al-Gubory","year":"2014","unstructured":"Al-Gubory KH. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reprod Biomed Online. 2014;29:17\u201331. https:\/\/doi.org\/10.1016\/j.rbmo.2014.03.002.","journal-title":"Reprod Biomed Online"},{"key":"4285_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cotox.2020.02.006","volume":"20\u201321","author":"Z Leni","year":"2020","unstructured":"Leni Z, K\u00fcnzi L, Geiser M. Air pollution causing oxidative stress. Curr Opin Toxicol. 2020;20\u201321:1\u20138. https:\/\/doi.org\/10.1016\/j.cotox.2020.02.006.","journal-title":"Curr Opin Toxicol"},{"key":"4285_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2015.00080","author":"A Mayr","year":"2016","unstructured":"Mayr A, Klambauer G, Unterthiner T, Hochreiter S. DeepTox: toxicity prediction using deep learning. Front Environ Sci. 2016. https:\/\/doi.org\/10.3389\/fenvs.2015.00080.","journal-title":"Front Environ Sci"},{"issue":"Suppl 19","key":"4285_CR42","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1186\/s12859-018-2523-5","volume":"19","author":"M Hirohara","year":"2018","unstructured":"Hirohara M, Saito Y, Koda Y, Sato K, Sakakibara Y. Convolutional neural network based on SMILES representation of compounds for detecting chemical motif. BMC Bioinf. 2018;19(Suppl 19):526. https:\/\/doi.org\/10.1186\/s12859-018-2523-5.","journal-title":"BMC Bioinf"},{"key":"4285_CR43","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.taap.2013.06.014","volume":"272","author":"LP Wills","year":"2013","unstructured":"Wills LP, Beeson GC, Trager RE, Lindsey CC, Beeson CC, Peterson YK, et al. High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury. Toxicol Appl Pharmacol. 2013;272:490\u2013502. https:\/\/doi.org\/10.1016\/j.taap.2013.06.014.","journal-title":"Toxicol Appl Pharmacol"},{"key":"4285_CR44","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nrd.2018.174","volume":"17","author":"MP Murphy","year":"2018","unstructured":"Murphy MP, Hartley RC. Mitochondria as a therapeutic target for common pathologies. Nat Rev Drug Discov. 2018;17:865\u201386. https:\/\/doi.org\/10.1038\/nrd.2018.174.","journal-title":"Nat Rev Drug Discov"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-021-04285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12859-021-04285-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-021-04285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T13:04:30Z","timestamp":1626354270000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-021-04285-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":44,"journal-issue":{"issue":"S10","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["4285"],"URL":"https:\/\/doi.org\/10.1186\/s12859-021-04285-3","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"13 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"369"}}