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For instance, one of the many ramifications of the COVID-19 global pandemic has been to make even more evident the importance of having bioinformatics tools and data readily actionable by researchers through convenient access points and supported by adequate IT infrastructures. One of the most successful efforts in improving the availability and usability of bioinformatics tools and data is represented by the Galaxy workflow manager and its thriving community. In 2020 we introduced Laniakea, a software platform conceived to streamline the configuration and deployment of \u201con-demand\u201d Galaxy instances over the cloud. By facilitating the set-up and configuration of Galaxy web servers, Laniakea provides researchers with a powerful and highly customisable platform for executing complex bioinformatics analyses. The system can be accessed through a dedicated and user-friendly web interface that allows the Galaxy web server\u2019s initial configuration and deployment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u201cLaniakea@ReCaS\u201d, the first instance of a Laniakea-based service, is managed by ELIXIR-IT and was officially launched in February 2020, after about one year of development and testing that involved several users. Researchers can request access to Laniakea@ReCaS through an open-ended call for use-cases. Ten project proposals have been accepted since then, totalling 18 Galaxy on-demand virtual servers that employ\u2009~\u2009100 CPUs,\u2009~\u2009250\u00a0GB of RAM and\u2009~\u20095\u00a0TB of storage and serve several different communities and purposes. Herein, we present eight use cases demonstrating the versatility of the platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During this first year of activity, the Laniakea-based service emerged as a flexible platform that facilitated the rapid development of bioinformatics tools, the efficient delivery of training activities, and the provision of public bioinformatics services in different settings, including food safety and clinical research. Laniakea@ReCaS provides a proof of concept of how enabling access to appropriate, reliable IT resources and ready-to-use bioinformatics tools can considerably streamline researchers\u2019 work.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-021-04401-3","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T17:19:45Z","timestamp":1636391985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Laniakea@ReCaS: exploring the potential of customisable Galaxy on-demand instances as a cloud-based service"],"prefix":"10.1186","volume":"22","author":[{"given":"Marco Antonio","family":"Tangaro","sequence":"first","affiliation":[]},{"given":"Pietro","family":"Mandreoli","sequence":"additional","affiliation":[]},{"given":"Matteo","family":"Chiara","sequence":"additional","affiliation":[]},{"given":"Giacinto","family":"Donvito","sequence":"additional","affiliation":[]},{"given":"Marica","family":"Antonacci","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Parisi","sequence":"additional","affiliation":[]},{"given":"Angelica","family":"Bianco","sequence":"additional","affiliation":[]},{"given":"Angelo","family":"Romano","sequence":"additional","affiliation":[]},{"given":"Daniela Manila","family":"Bianchi","sequence":"additional","affiliation":[]},{"given":"Davide","family":"Cangelosi","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Uva","sequence":"additional","affiliation":[]},{"given":"Ivan","family":"Molineris","sequence":"additional","affiliation":[]},{"given":"Vladimir","family":"Nosi","sequence":"additional","affiliation":[]},{"given":"Raffaele A.","family":"Calogero","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Alessandri","sequence":"additional","affiliation":[]},{"given":"Elena","family":"Pedrini","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Mordenti","sequence":"additional","affiliation":[]},{"given":"Emanuele","family":"Bonetti","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Sangiorgi","sequence":"additional","affiliation":[]},{"given":"Graziano","family":"Pesole","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-4331","authenticated-orcid":false,"given":"Federico","family":"Zambelli","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"issue":"1","key":"4401_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13742-016-0135-4","volume":"5","author":"SR Piccolo","year":"2016","unstructured":"Piccolo SR, Frampton MB. 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