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However, the ICD systems are difficult to decode due to their many shortcomings, which can be addressed using ontology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An ICD ontology (ICDO) was developed to logically and scientifically represent ICD terms and their relations among different ICD terms. ICDO is also aligned with the Basic Formal Ontology (BFO) and reuses terms from existing ontologies. As a use case, the ICD10 and ICD9 diagnosis data from the 4CE website were extracted, mapped to ICDO, and analyzed using ICDO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have developed the ICDO to ontologize the ICD terms and relations. Different from existing disease ontologies, all ICD diseases in ICDO are defined as disease processes to describe their occurrence with other properties. The ICDO decomposes each disease term into different components, including anatomic entities, process profiles, etiological causes, output phenotype, etc. Over 900 ICD terms have been represented in ICDO. Many ICDO terms are presented in both English and Chinese. The ICD10\/ICD9-based diagnosis data of over 27,000 COVID-19 patients from 5 countries were extracted from the 4CE. A total of 917 COVID-19-related disease codes, each of which were associated with 1 or more cases in the 4CE dataset, were mapped to ICDO and further analyzed using the ICDO logical annotations. Our study showed that COVID-19 targeted multiple systems and organs such as the lung, heart, and kidney. Different acute and chronic kidney phenotypes were identified. Some kidney diseases appeared to result from other diseases, such as diabetes. Some of the findings could only be easily found using ICDO instead of ICD9\/10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ICDO was developed to ontologize ICD10\/10 codes and applied to study COVID-19 patient diagnosis data. Our findings showed that ICDO provides a semantic platform for more accurate detection of disease profiles.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-021-04402-2","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T16:02:56Z","timestamp":1659628976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development of the International Classification of Diseases Ontology (ICDO) and its application for COVID-19 diagnostic data analysis"],"prefix":"10.1186","volume":"22","author":[{"given":"Ling","family":"Wan","sequence":"first","affiliation":[]},{"given":"Justin","family":"Song","sequence":"additional","affiliation":[]},{"given":"Virginia","family":"He","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Roman","sequence":"additional","affiliation":[]},{"given":"Grace","family":"Whah","sequence":"additional","affiliation":[]},{"given":"Suyuan","family":"Peng","sequence":"additional","affiliation":[]},{"given":"Luxia","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-9661","authenticated-orcid":false,"given":"Yongqun","family":"He","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"issue":"1","key":"4402_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00185868.2015.1119549","volume":"94","author":"JH Stephens","year":"2016","unstructured":"Stephens JH, Ledlow GR, Fockler TV. 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