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This study aims to avoid defects in traditional skull ancestry estimation methods, such as time-consuming and labor-intensive manual calibration of feature points, and subjective results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This paper uses the skull depth image as input, based on AlexNet, introduces the Wide module and SE-block to improve the network, designs and proposes ANINet, and realizes the ancestry classification. Such a unified model architecture of ANINet overcomes the subjectivity of manually calibrating feature points, of which the accuracy and efficiency are improved. We use depth projection to obtain the local depth image and the global depth image of the skull, take the skull depth image as the object, use global, local, and local\u2009+\u2009global methods respectively to experiment on the 95 cases of Han skull and 110 cases of Uyghur skull data sets, and perform cross-validation. The experimental results show that the accuracies of the three methods for skull ancestry estimation reached 98.21%, 98.04% and 99.03%, respectively. Compared with the classic networks AlexNet, Vgg-16, GoogLenet, ResNet-50, DenseNet-121, and SqueezeNet, the network proposed in this paper has the advantages of high accuracy and small parameters; compared with state-of-the-art methods, the method in this paper has a higher learning rate and better ability to estimate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In summary, skull depth images have an excellent performance in estimation, and ANINet is an effective approach for skull ancestry estimation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-021-04444-6","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T15:02:43Z","timestamp":1636642963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["ANINet: a deep neural network for skull ancestry estimation"],"prefix":"10.1186","volume":"22","author":[{"given":"Lin","family":"Pengyue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Siyuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Xiaoning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng","family":"Guohua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Shixiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"issue":"4","key":"4444_CR1","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1111\/1556-4029.13699","volume":"63","author":"RE Murphy","year":"2018","unstructured":"Murphy RE, Garvin HM. 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