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Therefore, recently, the demand to more efficiently and effectively identify drug\u2013target interactions (DTIs) has intensified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We treat the prediction of DTIs as a ranking problem and propose a neural network architecture, NeuRank, to address it. Also, we assume that similar drug compounds are likely to interact with similar target proteins. Thus, in our model, we add drug and target similarities, which are very effective at improving the prediction of DTIs. Then, we develop NeuRank from a point-wise to a pair-wise, and further to list-wise model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Finally, results from extensive experiments on five public data sets (DrugBank, Enzymes, Ion Channels, G-Protein-Coupled Receptors, and Nuclear Receptors) show that, in identifying DTIs, our models achieve better performance than other state-of-the-art methods.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-021-04476-y","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T08:03:23Z","timestamp":1637913803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["NeuRank: learning to rank with neural networks for drug\u2013target interaction prediction"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiujin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuze","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"issue":"3","key":"4476_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1109\/TCBB.2016.2530062","volume":"14","author":"A Ezzat","year":"2016","unstructured":"Ezzat A, Zhao P, Wu M, Li X-L, Kwoh C-K. 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