{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:30:17Z","timestamp":1780576217043,"version":"3.54.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>When researchers perform gene family analysis, they often analyze the structural characteristics of the gene, such as the distribution of introns and exons. At the same time, characteristic structural analysis of amino acid sequence is also essential, for example, motif and domain features. Researchers often integrate these analyses into one image to dig out more information, but the tools responsible for this integration are lacking.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Here, we developed a tool (CFVisual) for drawing gene structure and protein architecture. CFVisual can draw the phylogenetic tree, gene structure, and protein architecture in one picture, and has rich interactive capabilities, which can meet the work needs of researchers. Furthermore, it also supports arbitrary stitching of the above analysis images. It has become a useful helper in gene family analysis. The CFVisual package was implemented in Python and is freely available from <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/ChenHuilong1223\/CFVisual\/\">https:\/\/github.com\/ChenHuilong1223\/CFVisual\/<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CFVisual has been used by some researchers and cited by some articles. In the future, CFVisual will continue to serve as a good helper for researchers in the study of gene structure and protein architecture.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12859-022-04707-w","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T08:04:09Z","timestamp":1652429049000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["CFVisual: an interactive desktop platform for drawing gene structure and protein architecture"],"prefix":"10.1186","volume":"23","author":[{"given":"Huilong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"issue":"8","key":"4707_CR1","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/bioinformatics\/btu817","volume":"31","author":"B Hu","year":"2015","unstructured":"Hu B, Jin J, Guo A-Y, Zhang H, Luo J, Gao G. GSDS 2.0: an upgraded gene feature visualization server. Bioinformatics. 2015;31(8):1296\u20137.","journal-title":"Bioinformatics"},{"issue":"suppl_2","key":"4707_CR2","doi-asserted-by":"publisher","first-page":"W202","DOI":"10.1093\/nar\/gkp335","volume":"37","author":"TL Bailey","year":"2009","unstructured":"Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 2009;37(suppl_2):W202\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4707_CR3","doi-asserted-by":"publisher","first-page":"D222","DOI":"10.1093\/nar\/gkt1223","volume":"42","author":"RD Finn","year":"2014","unstructured":"Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR, Heger A, Hetherington K, Holm L, Mistry J. Pfam: the protein families database. 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Nucleic Acids Res. 2010;39(suppl_1):D225\u20139.","journal-title":"Nucleic Acids Res"},{"key":"4707_CR5","doi-asserted-by":"crossref","unstructured":"SMART: recent updates, new developments and status in 2020. https:\/\/academic.oup.com\/nar\/article\/49\/D1\/D458\/5940513?login=false.","DOI":"10.1093\/nar\/gkaa937"},{"issue":"1","key":"4707_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1939-8433-6-4","volume":"6","author":"Y Kawahara","year":"2013","unstructured":"Kawahara Y, de la Bastide M, Hamilton JP, Kanamori H, McCombie WR, Ouyang S, Schwartz DC, Tanaka T, Wu J, Zhou S. Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data. Rice. 2013;6(1):1\u201310.","journal-title":"Rice"},{"issue":"12","key":"4707_CR7","doi-asserted-by":"publisher","first-page":"e121","DOI":"10.1093\/nar\/gkt263","volume":"41","author":"J Mistry","year":"2013","unstructured":"Mistry J, Finn RD, Eddy SR, Bateman A, Punta M. Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions. Nucleic Acids Res. 2013;41(12):e121\u2013e121.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"4707_CR8","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/molbev\/msy096","volume":"35","author":"S Kumar","year":"2018","unstructured":"Kumar S, Stecher G, Li M, Knyaz C, Tamura K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol. 2018;35(6):1547\u20139.","journal-title":"Mol Biol Evol"},{"issue":"1","key":"4707_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/nar\/30.1.325","volume":"30","author":"M Lescot","year":"2002","unstructured":"Lescot M, D\u00e9hais P, Thijs G, Marchal K, Moreau Y, Van de Peer Y, Rouz\u00e9 P, Rombauts S. PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences. 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