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However, reliable miRNA prognostic models for stomach adenocarcinoma remain to be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the data from the Cancer Genome Atlas (TCGA), a prognostic model of stomach adenocarcinoma was established including tumor stage and expression levels of 4 miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p, hsa-miR-6499-5p and hsa-miR-6807-3p). A total of 50 ultimate target genes of these miRNAs were obtained through prediction. Enrichment analysis revealed that target genes were mainly concentrated in neural function and TGF-\u03b2 and FoxO signaling pathways. Survival analysis showed that three model miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p and hsa-miR-6807-3p) and five final target genes (<jats:italic>DLC1<\/jats:italic>,<jats:italic>LRFN5<\/jats:italic>,<jats:italic>NOVA1<\/jats:italic>,<jats:italic>POU3F2<\/jats:italic>and<jats:italic>PRICKLE2<\/jats:italic>) were associated with the patient's overall survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We used bioinformatics methods to screen new prognostic miRNA markers from TCGA and established a prognostic model of STAD, so as to provide a basis for the diagnosis, prognosis, and treatment of STAD in the future.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12859-022-04719-6","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T12:03:12Z","timestamp":1652702592000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of miRNA biomarkers for stomach adenocarcinoma"],"prefix":"10.1186","volume":"23","author":[{"given":"Hao","family":"Qian","sequence":"first","affiliation":[]},{"given":"Nanxue","family":"Cui","sequence":"additional","affiliation":[]},{"given":"Qiao","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Shihai","family":"Zhang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"issue":"3","key":"4719_CR1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. 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