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The literature and online databases contain hundreds of experimentally validated molecule-TF pairs; however, the knowledge is scattered and often incomplete. Additionally, compared to the number of compounds that can be produced in living systems, those with known associated TF-compound interactions are low. For these reasons, new tools that help researchers find new possible TF-ligand pairs are called for. In this work, we present Sensbio, a computational tool that through similarity comparison against a TF-ligand reference database, is able to identify putative transcription factors that can be activated by a given input molecule. In addition to the collection of algorithms, an online application has also been developed, together with a predictive model created to find new possible matches based on machine learning.<\/jats:p>","DOI":"10.1186\/s12859-023-05201-7","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:36:48Z","timestamp":1677739008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sensbio: an online server for biosensor design"],"prefix":"10.1186","volume":"24","author":[{"given":"Jonathan","family":"Tellechea-Luzardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e8ctor","family":"Mart\u00edn L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Moreno L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Carbonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"5201_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00648","author":"R Fernandez-L\u00f3pez","year":"2015","unstructured":"Fernandez-L\u00f3pez R, Ruiz R, de la Cruz F, Moncali\u00e1n G. 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