{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:49:46Z","timestamp":1771598986807,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["740132"],"award-info":[{"award-number":["740132"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n In this work we present $$\\texttt {life}^{\\texttt {x}}$$<\/jats:tex-math>\n \n life<\/mml:mi>\n x<\/mml:mi>\n <\/mml:msup>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>-fiber, an innovative tool for the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations. $$\\texttt {life}^{\\texttt {x}}$$<\/jats:tex-math>\n \n life<\/mml:mi>\n x<\/mml:mi>\n <\/mml:msup>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>-fiber is the first publicly released module for cardiac simulations based on $$\\texttt {life}^{\\texttt {x}}$$<\/jats:tex-math>\n \n life<\/mml:mi>\n x<\/mml:mi>\n <\/mml:msup>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>, an open-source, high-performance Finite Element solver for multi-physics, multi-scale and multi-domain problems developed in the framework of the iHEART project, which aims at making in silico<\/jats:italic> experiments easily reproducible and accessible to a wide community of users, including those with a background in medicine or bio-engineering.<\/jats:p>\n <\/jats:sec>\n Conclusions<\/jats:title>\n The tool presented in this document is intended to provide the scientific community with a computational tool that incorporates general state of the art models and solvers for simulating the cardiac function within a high-performance framework that exposes a user- and developer-friendly interface. This report comes with an extensive technical and mathematical documentation to welcome new users to the core structure of $$\\texttt {life}^{\\texttt {x}}$$<\/jats:tex-math>\n \n life<\/mml:mi>\n x<\/mml:mi>\n <\/mml:msup>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>-fiber and to provide them with a possible approach to include the generated cardiac fibers into more sophisticated computational pipelines. In the near future, more modules will be successively published either as pre-compiled binaries for systems or as open source software.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12859-023-05260-w","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T11:03:03Z","timestamp":1681297383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["lifex-fiber: an open tool for myofibers generation in cardiac computational models"],"prefix":"10.1186","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-8564","authenticated-orcid":false,"given":"Pasquale Claudio","family":"Africa","sequence":"first","affiliation":[]},{"given":"Roberto","family":"Piersanti","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Fedele","sequence":"additional","affiliation":[]},{"given":"Luca","family":"Dede\u2019","sequence":"additional","affiliation":[]},{"given":"Alfio","family":"Quarteroni","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"5260_CR1","doi-asserted-by":"publisher","unstructured":"Quarteroni A, Dede\u2019 L, Manzoni A, Vergara C. 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