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Recent single-cell RNA-sequencing studies focus on CCIs based on ligand\u2013receptor (L\u2013R) gene co-expression but the analytical methods are not appropriate to detect many-to-many CCIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this work, we propose , a novel method for extracting representative triadic relationships (or hypergraphs), which include ligand-expression, receptor-expression, and related L\u2013R pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Through extensive studies with simulated and empirical datasets, we have shown that  can detect some hypergraphs that cannot be detected using conventional CCI detection methods, especially when they include many-to-many relationships.  is implemented as a freely available R\/Bioconductor package.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12859-023-05490-y","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:02:05Z","timestamp":1699362125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sctensor detects many-to-many cell\u2013cell interactions from single cell RNA-sequencing data"],"prefix":"10.1186","volume":"24","author":[{"given":"Koki","family":"Tsuyuzaki","sequence":"first","affiliation":[]},{"given":"Manabu","family":"Ishii","sequence":"additional","affiliation":[]},{"given":"Itoshi","family":"Nikaido","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"issue":"2","key":"5490_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/jcm5020026","volume":"5","author":"Y Yu","year":"2016","unstructured":"Yu Y, Elble RC. 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