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We introduce : a publicly accessible  package and web application platform to easily perform in silico hypothesis testing of generated gene regulatory networks. We demonstrate the utility of  by conducting an end-to-end analysis in a statistical genetics application focused on measuring the effect of in silico perturbations of complex trait architecture. By using a real dataset from the Wellcome Trust Centre for Human Genetics, we both recapitulate previous findings and propose hypotheses about the genes involved in the percentage of immune CD8+ cells found in heterogeneous stocks of mice. Source code for the  package is available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/lcrawlab\/multio-viz\">https:\/\/github.com\/lcrawlab\/multio-viz<\/jats:ext-link> and an interactive version of the platform is available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/multioviz.ccv.brown.edu\/\">https:\/\/multioviz.ccv.brown.edu\/<\/jats:ext-link>.<\/jats:p>","DOI":"10.1186\/s12859-024-05819-1","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:03:05Z","timestamp":1722362585000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multioviz: an interactive platform for in silico perturbation and interrogation of gene regulatory networks"],"prefix":"10.1186","volume":"25","author":[{"given":"Helen","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-8242","authenticated-orcid":false,"given":"Lorin","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-6180","authenticated-orcid":false,"given":"Ashley Mae","family":"Conard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"issue":"12","key":"5819_CR1","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/35103535","volume":"2","author":"AC Syv\u00e4nen","year":"2001","unstructured":"Syv\u00e4nen AC. 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