{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:30:15Z","timestamp":1771079415178,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100014365","name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/501100014365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014365","name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/501100014365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Rio Hortega CM21-00165"],"award-info":[{"award-number":["Rio Hortega CM21-00165"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00997"],"award-info":[{"award-number":["PI18\/00997"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Sara Borrell CD22-00014"],"award-info":[{"award-number":["Sara Borrell CD22-00014"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Miguel Servet CPII19\/00002"],"award-info":[{"award-number":["Miguel Servet CPII19\/00002"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["TEC-2024\/COM-893"],"award-info":[{"award-number":["TEC-2024\/COM-893"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["TEC-2024\/COM-893"],"award-info":[{"award-number":["TEC-2024\/COM-893"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["TEC-2024\/COM-893"],"award-info":[{"award-number":["TEC-2024\/COM-893"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"DOI":"10.1186\/s12859-025-06200-6","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T17:03:49Z","timestamp":1752771829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Automated web-based typing of Clostridioides difficile ribotypes via MALDI-TOF MS"],"prefix":"10.1186","volume":"26","author":[{"given":"Mario","family":"Bl\u00e1zquez-S\u00e1nchez","sequence":"first","affiliation":[]},{"given":"Alejandro","family":"Guerrero-L\u00f3pez","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Candela","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Belenguer-Llorens","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Miguel","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Sevilla-Salcedo","sequence":"additional","affiliation":[]},{"given":"Mar\u00eda","family":"S\u00e1nchez-Cueto","sequence":"additional","affiliation":[]},{"given":"Manuel J.","family":"Arroyo","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Guti\u00e9rrez-Pareja","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"G\u00f3mez-Verdejo","sequence":"additional","affiliation":[]},{"given":"Pablo M.","family":"Olmos","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Mancera","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[]},{"given":"Mercedes","family":"Mar\u00edn","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Alcal\u00e1","sequence":"additional","affiliation":[]},{"given":"David","family":"Rodr\u00edguez-Temporal","sequence":"additional","affiliation":[]},{"given":"Bel\u00e9n","family":"Rodr\u00edguez-S\u00e1nchez","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"6200_CR1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10096-019-03539-6","volume":"38","author":"J Czepiel","year":"2019","unstructured":"Czepiel J, Dr\u00f3\u017cd\u017c M, Pituch H, Kuijper EJ, Perucki W, Mielimonka A, et al. Clostridium difficile infection. Eur J Clin Microbiol Infect Dis. 2019;38:1211\u201321.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"6200_CR2","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/microorganisms11040845","volume":"11","author":"R Markovska","year":"2023","unstructured":"Markovska R, Dimitrov G, Gergova R, Boyanova L. Clostridioides difficile, a New \u201cSuperbug\u2019\u2019. Microorganisms. 2023;11(4):845.","journal-title":"Microorganisms"},{"issue":"1","key":"6200_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/ng.2478","volume":"45","author":"M He","year":"2013","unstructured":"He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet. 2013;45(1):109\u201313.","journal-title":"Nat Genet"},{"issue":"26","key":"6200_CR4","doi-asserted-by":"publisher","first-page":"2100704","DOI":"10.2807\/1560-7917.ES.2022.27.26.2100704","volume":"27","author":"VF Viprey","year":"2022","unstructured":"Viprey VF, Davis GL, Benson AD, Ewin D, Spittal W, Vernon JJ, et al. A point-prevalence study on community and inpatient Clostridioides difficile infections (CDI): results from combatting bacterial resistance in Europe CDI (COMBACTE-CDI), July to November 2018. Eurosurveillance. 2022;27(26):2100704.","journal-title":"Eurosurveillance"},{"key":"6200_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2022.102601","volume":"76","author":"M Kachrimanidou","year":"2022","unstructured":"Kachrimanidou M, Metallidis S, Tsachouridou O, Harmanus C, Lola V, Protonotariou E, et al. Predominance of Clostridioides difficile PCR ribotype 181 in northern Greece, 2016\u20132019. Anaerobe. 2022;76: 102601.","journal-title":"Anaerobe"},{"key":"6200_CR6","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1007\/s42770-021-00563-7","volume":"52","author":"Y Bai","year":"2021","unstructured":"Bai Y, Hao Y, Song Z, Chu W, Jin Y, Wang Y. Evaluation of the Cepheid Xpert C. difficile diagnostic assay: an update meta-analysis. Braz J Microbiol. 2021;52:1937\u201349.","journal-title":"Braz J Microbiol"},{"issue":"2","key":"6200_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/jcla.21655","volume":"28","author":"DH Whang","year":"2014","unstructured":"Whang DH, Joo SY. Evaluation of the diagnostic performance of the Xpert Clostridium difficile assay and its comparison with the Toxin A\/B enzyme-linked fluorescent assay and in-house real-time PCR assay used for the detection of toxigenic C. difficile. J Clin Lab Anal. 2014;28(2):124\u20139.","journal-title":"J Clin Lab Anal"},{"issue":"11","key":"6200_CR8","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.3390\/jcm9113738","volume":"9","author":"E Novakova","year":"2020","unstructured":"Novakova E, Kotlebova N, Gryndlerova A, Novak M, Vladarova M, Wilcox M, et al. An outbreak of clostridium (Clostridioides) difficile infections within an acute and long-term care wards due to moxifloxacin-resistant PCR Ribotype 176 genotyped as PCR Ribotype 027 by a commercial assay. J Clin Med. 2020;9(11):3738.","journal-title":"J Clin Med"},{"key":"6200_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2020.102252","volume":"65","author":"M Kachrimanidou","year":"2020","unstructured":"Kachrimanidou M, Baktash A, Metallidis S, Tsachouridou O, Netsika F, Dimoglou D, et al. An outbreak of Clostridioides difficile infections due to a 027-like PCR ribotype 181 in a rehabilitation centre: epidemiological and microbiological characteristics. Anaerobe. 2020;65: 102252.","journal-title":"Anaerobe"},{"issue":"7","key":"6200_CR10","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3390\/microorganisms10071477","volume":"10","author":"A Calderaro","year":"2022","unstructured":"Calderaro A, Buttrini M, Farina B, Montecchini S, Martinelli M, Arcangeletti MC, et al. Characterization of Clostridioides difficile strains from an outbreak using maldi-tof mass spectrometry. Microorganisms. 2022;10(7):1477.","journal-title":"Microorganisms"},{"issue":"3","key":"6200_CR11","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1128\/CMR.00072-12","volume":"26","author":"AE Clark","year":"2013","unstructured":"Clark AE, Kaleta EJ, Arora A, Wolk DM. Matrix-assisted laser desorption ionization-time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology. Clin Microbiol Rev. 2013;26(3):547\u2013603.","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"6200_CR12","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s10096-023-04665-y","volume":"42","author":"AMM Abdrabou","year":"2023","unstructured":"Abdrabou AMM, Sy I, Bischoff M, Arroyo MJ, Becker SL, Mellmann A, et al. Discrimination between hypervirulent and non-hypervirulent ribotypes of Clostridioides difficile by MALDI-TOF mass spectrometry and machine learning. Eur J Clin Microbiol Infect Dis. 2023;42(11):1373\u201381.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"6200_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122457","volume":"10","author":"K Rizzardi","year":"2015","unstructured":"Rizzardi K, \u00c5kerlund T. High molecular weight typing with MALDI-TOF MS-a novel method for rapid typing of Clostridium difficile. PLoS ONE. 2015;10(4): e0122457.","journal-title":"PLoS ONE"},{"key":"6200_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.anaerobe.2018.04.013","volume":"54","author":"L Ortega","year":"2018","unstructured":"Ortega L, Ryberg A, Johansson \u00c5. HMW-profiling using MALDI-TOF MS: a screening method for outbreaks of Clostridioides difficile. Anaerobe. 2018;54:254\u20139.","journal-title":"Anaerobe"},{"issue":"2","key":"6200_CR15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10096-024-05023-2","volume":"44","author":"A Candela","year":"2025","unstructured":"Candela A, Rodriguez-Temporal D, Bl\u00e1zquez-S\u00e1nchez M, Arroyo MJ, Mar\u00edn M, Alcal\u00e1 L, et al. Analysis of high-molecular-weight proteins using MALDI-TOF MS and machine learning for the differentiation of clinically relevant Clostridioides difficile ribotypes. Eur J Clin Microbiol Infect Dis. 2025;44(2):417\u201325.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"6200_CR16","unstructured":"ECDC. European Centre for Disease Prevention and Control. Clostridioides (Clostridium) difficile infections: annual epidemiological report for 2016\u20132017. Annual epidemiological report; 2022."},{"issue":"11","key":"6200_CR17","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1099\/jmm.0.47714-0","volume":"57","author":"A Indra","year":"2008","unstructured":"Indra A, Huhulescu S, Schneeweis M, Hasenberger P, Kernbichler S, Fiedler A, et al. Characterization of Clostridium difficile isolates using capillary gel electrophoresis-based PCR ribotyping. J Med Microbiol. 2008;57(11):1377\u201382.","journal-title":"J Med Microbiol"},{"issue":"1","key":"6200_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1128\/AAC.04082-14","volume":"59","author":"M Mar\u00edn","year":"2015","unstructured":"Mar\u00edn M, Mart\u00edn A, Alcal\u00e1 L, Cercenado E, Iglesias C, Reigadas E, et al. Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene CFR. Antimicrob Agents Chemother. 2015;59(1):586\u20139.","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"6200_CR19","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1128\/JCM.38.7.2484-2487.2000","volume":"38","author":"P Bidet","year":"2000","unstructured":"Bidet P, Lalande V, Salauze B, Burghoffer B, Avesani V, Delm\u00e9e M, et al. Comparison of PCR-ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile. J Clin Microbiol. 2000;38(7):2484\u20137.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"6200_CR20","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3390\/diagnostics12020328","volume":"12","author":"A Candela","year":"2022","unstructured":"Candela A, Arroyo MJ, S\u00e1nchez-Molleda \u00c1, M\u00e9ndez G, Quiroga L, Ruiz A, et al. Rapid and reproducible MALDI-TOF-based method for the detection of vancomycin-resistant Enterococcus faecium using classifying algorithms. Diagnostics. 2022;12(2):328.","journal-title":"Diagnostics"},{"key":"6200_CR21","doi-asserted-by":"crossref","unstructured":"Santiago LS, Guerrero-L\u00f3pez A, Sevilla-Salcedo C, Rodr\u00edguez-Temporal D, Rodr\u00edguez-S\u00e1nchez B, G\u00f3mez-Verdejo V. Machine learning applied to MALDI-TOF data in a clinical setting: a systematic review. bioRxiv; 2025; 2025\u201301.","DOI":"10.1101\/2025.01.25.634879"},{"key":"6200_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2022.105644","volume":"118","author":"A Guerrero-L\u00f3pez","year":"2023","unstructured":"Guerrero-L\u00f3pez A, Sevilla-Salcedo C, Candela A, Hern\u00e1ndez-Garc\u00eda M, Cercenado E, Olmos PM, et al. Automatic antibiotic resistance prediction in klebsiella pneumoniae based on maldi-tof mass spectra. Eng Appl Artif Intell. 2023;118: 105644.","journal-title":"Eng Appl Artif Intell"},{"issue":"1","key":"6200_CR23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41591-021-01619-9","volume":"28","author":"C Weis","year":"2022","unstructured":"Weis C, Cu\u00e9nod A, Rieck B, Dubuis O, Graf S, Lang C, et al. Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning. Nat Med. 2022;28(1):164\u201374.","journal-title":"Nat Med"},{"issue":"Supplement\u20131","key":"6200_CR24","doi-asserted-by":"publisher","first-page":"i30","DOI":"10.1093\/bioinformatics\/btaa429","volume":"36","author":"C Weis","year":"2020","unstructured":"Weis C, Horn M, Rieck B, Cu\u00e9nod A, Egli A, Borgwardt K. Topological and kernel-based microbial phenotype prediction from MALDI-TOF mass spectra. Bioinformatics. 2020;36(Supplement\u20131):i30\u20138.","journal-title":"Bioinformatics"},{"issue":"5","key":"6200_CR25","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.3390\/app12052571","volume":"12","author":"A Belenguer-Llorens","year":"2022","unstructured":"Belenguer-Llorens A, Sevilla-Salcedo C, Desco M, Soto-Montenegro ML, G\u00f3mez-Verdejo V. A novel Bayesian linear regression model for the analysis of neuroimaging data. Appl Sci. 2022;12(5):2571.","journal-title":"Appl Sci"},{"key":"6200_CR26","unstructured":"Guerrero-L\u00f3pez A, Sevilla-Salcedo C, G\u00f3mez-Verdejo V, Olmos PM. Multiview hierarchical variational autoencoders with factor analysis latent space. arXiv preprint arXiv:2207.09185; 2022."},{"issue":"1","key":"6200_CR27","first-page":"8649429","volume":"2023","author":"A Candela","year":"2023","unstructured":"Candela A, Arroyo MJ, S\u00e1nchez-Cueto M, Mar\u00edn M, Cercenado E, M\u00e9ndez G, et al. Rapid discrimination of pseudomonas aeruginosa ST175 isolates involved in a nosocomial outbreak using MALDI-TOF mass spectrometry and FTIR spectroscopy coupled with machine learning. Transbound Emerg Dis. 2023;2023(1):8649429.","journal-title":"Transbound Emerg Dis"},{"issue":"8","key":"6200_CR28","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1021\/jasms.2c00110","volume":"33","author":"H Hamidi","year":"2022","unstructured":"Hamidi H, Bagheri Nejad R, Es-Haghi A, Ghassempour A. A combination of MALDI-TOF MS proteomics and species-unique biomarkers\u2019 discovery for rapid screening of brucellosis. J Am Soc Mass Spectrom. 2022;33(8):1530\u201340.","journal-title":"J Am Soc Mass Spectrom"},{"issue":"3","key":"6200_CR29","doi-asserted-by":"publisher","first-page":"e04995-22","DOI":"10.1128\/spectrum.04995-22","volume":"11","author":"EJ Busby","year":"2023","unstructured":"Busby EJ, Doyle RM, Leboreiro Babe C, Harris KA, Mack D, M\u00e9ndez-Cervantes G, et al. Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for molecular typing of Acinetobacter baumannii in comparison with orthogonal methods. Microbiol Spectr. 2023;11(3):e04995-22.","journal-title":"Microbiol Spectr"},{"issue":"1","key":"6200_CR30","doi-asserted-by":"publisher","first-page":"18945","DOI":"10.1038\/s41598-019-55430-1","volume":"9","author":"S Flores-Trevi\u00f1o","year":"2019","unstructured":"Flores-Trevi\u00f1o S, Garza-Gonz\u00e1lez E, Mendoza-Olazar\u00e1n S, Morf\u00edn-Otero R, Camacho-Ortiz A, Rodr\u00edguez-Noriega E, et al. Screening of biomarkers of drug resistance or virulence in ESCAPE pathogens by MALDI-TOF mass spectrometry. Sci Rep. 2019;9(1):18945.","journal-title":"Sci Rep"},{"key":"6200_CR31","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.3389\/fmicb.2019.02087","volume":"10","author":"MF Emele","year":"2019","unstructured":"Emele MF, Joppe FM, Riedel T, Overmann J, Rupnik M, Cooper P, et al. Proteotyping of Clostridioides difficile as alternate typing method to ribotyping is able to distinguish the ribotypes RT027 and RT176 from other ribotypes. Front Microbiol. 2019;10:2087.","journal-title":"Front Microbiol"},{"issue":"6","key":"6200_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.14478","volume":"17","author":"A Godmer","year":"2024","unstructured":"Godmer A, Giai Gianetto Q, Le Neindre K, Latapy V, Bastide M, Ehmig M, et al. Contribution of MALDI-TOF mass spectrometry and machine learning including deep learning techniques for the detection of virulence factors of Clostridioides difficile strains. Microb Biotechnol. 2024;17(6): e14478.","journal-title":"Microb Biotechnol"},{"issue":"7","key":"6200_CR33","doi-asserted-by":"publisher","first-page":"904-e1","DOI":"10.1016\/j.cmi.2018.10.008","volume":"25","author":"J Corver","year":"2019","unstructured":"Corver J, Sen J, Hornung B, Mertens B, Berssenbrugge E, Harmanus C, et al. Identification and validation of two peptide markers for the recognition of Clostridioides difficile MLST-1 and MLST-11 by MALDI-MS. Clin Microbiol Infect. 2019;25(7):904-e1.","journal-title":"Clin Microbiol Infect"},{"key":"6200_CR34","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bdr.2017.07.003","volume":"9","author":"R Genuer","year":"2017","unstructured":"Genuer R, Poggi JM, Tuleau-Malot C, Villa-Vialaneix N. Random forests for big data. Big Data Res. 2017;9:28\u201346.","journal-title":"Big Data Res"},{"key":"6200_CR35","unstructured":"Lasch P, St\u00e4mmler M, Schneider A. Version 4 (20230306) of the MALDI-tof mass spectrometry database for identification and classification of highly pathogenic microorganisms from the robert koch-institute (RKI); 2023."},{"issue":"3","key":"6200_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/14789450.2018.1438193","volume":"15","author":"M Kostrzewa","year":"2018","unstructured":"Kostrzewa M. Application of the MALDI Biotyper to clinical microbiology: progress and potential. Expert Rev Proteomics. 2018;15(3):193\u2013202.","journal-title":"Expert Rev Proteomics"},{"issue":"1","key":"6200_CR37","doi-asserted-by":"publisher","first-page":"2427804","DOI":"10.1080\/22221751.2024.2427804","volume":"13","author":"Maja Rupnik","year":"2024","unstructured":"Rupnik, Maja, et al. Distribution of Clostridioides difficile ribotypes and sequence types across humans, animals and food in 13 European countries. Emerg Microbes Infect. 2024;13(1):2427804. https:\/\/doi.org\/10.1080\/22221751.2024.2427804","journal-title":"Emerg Microbes Infect."}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-025-06200-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12859-025-06200-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12859-025-06200-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T13:27:04Z","timestamp":1757251624000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/s12859-025-06200-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6200"],"URL":"https:\/\/doi.org\/10.1186\/s12859-025-06200-6","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"17 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original publication, the funding and acknowledgement statements were incorrect. The article has been updated to rectify the errors.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the HGUGM Ethics Committee (CEIm) under study number MICRO.HGUGM.2021-025. Because only anonymized microbiological isolates were used and no human specimens or personal data were involved, the Committee waived the requirement for informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MJA and LM are employees of Clover Bioanalytical Software, S.L.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"181"}}