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While numerous software tools have been developed, current workflows are hindered by manual spreadsheet handling and insufficient data quality assessment prior to analysis. Here, we introduce\n                      <jats:italic>LipidCruncher<\/jats:italic>\n                      , an open-source, web-based platform designed to easily process, visualize, and analyze lipidomic data with high efficiency and rigor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LipidCruncher<\/jats:italic>\n                      consolidates key steps of the lipidomics analysis workflow, including data standardization, normalization, and stringent quality controls. The platform also provides advanced visualization and analysis tools that are tailored to interrogate lipidomic data and enable detailed and holistic data exploration. To illustrate\n                      <jats:italic>LipidCruncher<\/jats:italic>\n                      \u2019s utility, we analyzed lipidomic data from adipose tissue of mice lacking the triacylglycerol synthesis enzymes DGAT1 and DGAT2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>LipidCruncher<\/jats:italic>\n                      fills a specific gap in the lipidomics analysis ecosystem by providing an integrated, quality-focused platform that accepts data from multiple sources and complements existing specialized tools. By bridging the critical divide between data generation and biological interpretation,\n                      <jats:italic>LipidCruncher<\/jats:italic>\n                      facilitates rigorous lipidomics analyses to accelerate the translation of complex lipid profiles into biological insights.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12859-026-06483-3","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:05:10Z","timestamp":1780574710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["LipidCruncher: an open-source platform for processing, visualizing, and analyzing lipidomic data"],"prefix":"10.1186","volume":"27","author":[{"given":"Hamed","family":"Abdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes A.","family":"Ambaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zon Weng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchie","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandramohan","family":"Chitraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert V.","family":"Farese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias C.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"issue":"2","key":"6483_CR1","doi-asserted-by":"publisher","first-page":"100164","DOI":"10.1016\/j.jlr.2021.100164","volume":"63","author":"X Han","year":"2022","unstructured":"Han X, Gross RW. 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All animal experiments in that study were performed under the guidelines from Harvard Center for Comparative Medicine. No new animal experiments were conducted for this manuscript. Experimental procedures are detailed in Supplementary Methods S9.1-S9.3.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"171"}}