{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:35:04Z","timestamp":1775572504418,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12880-019-0326-4","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T12:02:54Z","timestamp":1555070574000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-7865","authenticated-orcid":false,"given":"Alexandra G.","family":"Gheorghe","sequence":"first","affiliation":[]},{"given":"Andreas","family":"Fuchs","sequence":"additional","affiliation":[]},{"given":"Christina","family":"Jacobsen","sequence":"additional","affiliation":[]},{"given":"Klaus F.","family":"Kofoed","sequence":"additional","affiliation":[]},{"given":"Rasmus","family":"M\u00f8gelvang","sequence":"additional","affiliation":[]},{"given":"Niels","family":"Lynnerup","sequence":"additional","affiliation":[]},{"given":"Jytte","family":"Banner","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"326_CR1","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jcmg.2015.04.019","volume":"8","author":"K Hoang","year":"2015","unstructured":"Hoang K, Zhao Y, Gardin JM, Carnethon M, Mukamal K, Yanez D, et al. LV mass as a predictor of CVD events in older adults with and without metabolic syndrome and diabetes. JACC Cardiovasc Imaging. 2015;8:1007\u201315. \n                    https:\/\/doi.org\/10.1016\/j.jcmg.2015.04.019\n                    \n                  .","journal-title":"JACC Cardiovasc Imaging"},{"key":"326_CR2","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jcmg.2012.06.003","volume":"5","author":"AC Armstrong","year":"2012","unstructured":"Armstrong AC, Gidding S, Gjesdal O, Wu C, Bluemke DA, Lima JAC. LV mass assessed by echocardiography and CMR, cardiovascular outcomes, and medical practice. JACC Cardiovasc Imaging. 2012;5:837\u201348. \n                    https:\/\/doi.org\/10.1016\/j.jcmg.2012.06.003\n                    \n                  .","journal-title":"JACC Cardiovasc Imaging"},{"key":"326_CR3","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.jcmg.2015.06.008","volume":"8","author":"SE Litwin","year":"2015","unstructured":"Litwin SE. Cardiac \u201cMorphomics.\u201d. JACC Cardiovasc Imaging. 2015;8:1016\u20138. \n                    https:\/\/doi.org\/10.1016\/j.jcmg.2015.06.008\n                    \n                  .","journal-title":"JACC Cardiovasc Imaging"},{"key":"326_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1476-7120-8-19","volume":"8","author":"AS Celebi","year":"2010","unstructured":"Celebi AS, Yalcin H, Yalcin F. Current cardiac imaging techniques for detection of left ventricular mass. Cardiovasc Ultrasound. 2010;8:19.","journal-title":"Cardiovasc Ultrasound"},{"key":"326_CR5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jchf.2017.01.005","volume":"5","author":"JE Udelson","year":"2017","unstructured":"Udelson JE. Left ventricular shape. JACC: Heart Failure. 2017;5:179\u201381. \n                    https:\/\/doi.org\/10.1016\/j.jchf.2017.01.005\n                    \n                  .","journal-title":"JACC: Heart Failure"},{"key":"326_CR6","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/hrt.49.4.309","volume":"49","author":"R Emanuel","year":"1983","unstructured":"Emanuel R, Marcomichelakis J, Withers R, O\u2019Brien K. Asymmetric septal hypertrophy and hypertrophic cardiomyopathy. Br Heart J. 1983;49:309.","journal-title":"Br Heart J"},{"key":"326_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-7120-8-7","volume":"8","author":"M-A Losi","year":"2010","unstructured":"Losi M-A, Nistri S, Galderisi M, Betocchi S, Cecchi F, Olivotto I, et al. Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment. Cardiovasc Ultrasound. 2010;8:7.","journal-title":"Cardiovasc Ultrasound"},{"key":"326_CR8","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"RM Lang","year":"2005","unstructured":"Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography\u2019s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440\u201363. \n                    https:\/\/doi.org\/10.1016\/j.echo.2005.10.005\n                    \n                  .","journal-title":"J Am Soc Echocardiogr"},{"key":"326_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jcct.2012.01.006","volume":"6","author":"A Fuchs","year":"2012","unstructured":"Fuchs A, K\u00fchl JT, L\u00f8nborg J, Engstr\u00f8m T, Vejlstrup N, K\u00f8ber L, et al. Automated assessment of heart chamber volumes and function in patients with previous myocardial infarction using multidetector computed tomography. Journal of Cardiovascular Computed Tomography. 2012;6:325\u201334. \n                    https:\/\/doi.org\/10.1016\/j.jcct.2012.01.006\n                    \n                  .","journal-title":"Journal of Cardiovascular Computed Tomography"},{"key":"326_CR10","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1093\/ehjci\/jev337","volume":"17","author":"A Fuchs","year":"2016","unstructured":"Fuchs A, Mejdahl MR, K\u00fchl JT, Stisen ZR, Nilsson EJP, K\u00f8ber LV, et al. Normal values of left ventricular mass and cardiac chamber volumes assessed by 320-detector computed tomography angiography in the Copenhagen general population study. Eur Heart J Cardiovasc Imaging. 2016;17:1009\u201317. \n                    https:\/\/doi.org\/10.1093\/ehjci\/jev337\n                    \n                  .","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"326_CR11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s10554-016-1015-9","volume":"33","author":"L Hinds\u00f8","year":"2017","unstructured":"Hinds\u00f8 L, Fuchs A, K\u00fchl JT, Nilsson EJP, Sigvardsen PE, K\u00f8ber L, et al. Normal values of regional left ventricular myocardial thickness, mass and distribution-assessed by 320-detector computed tomography angiography in the Copenhagen general population study. Int J Card Imaging. 2017;33:421\u20139. \n                    https:\/\/doi.org\/10.1007\/s10554-016-1015-9\n                    \n                  .","journal-title":"Int J Card Imaging"},{"key":"326_CR12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","volume":"57","author":"RB Devereux","year":"1986","unstructured":"Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450\u20138.","journal-title":"Am J Cardiol"},{"key":"326_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.forsciint.2004.05.019","volume":"149","author":"C Jackowski","year":"2005","unstructured":"Jackowski C, Schweitzer W, Thali M, Yen K, Aghayev E, Sonnenschein M, et al. Virtopsy: postmortem imaging of the human heart in situ using MSCT and MRI. Forensic Sci Int. 2005;149:11\u201323. \n                    https:\/\/doi.org\/10.1016\/j.forsciint.2004.05.019\n                    \n                  .","journal-title":"Forensic Sci Int"},{"key":"326_CR14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/BF00960587","volume":"342","author":"W Masshoff","year":"1967","unstructured":"Masshoff W, Scheidt D, Reimers HF. Quantitative Bestimmung des Fett-und Myokardgewebes im Leichenherzen. Virchows Arch. 1967;342:184\u20139.","journal-title":"Virchows Arch"},{"key":"326_CR15","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1007\/s00330-008-0939-4","volume":"18","author":"P Stolzmann","year":"2008","unstructured":"Stolzmann P, Scheffel H, Leschka S, Schertler T, Frauenfelder T, Kaufmann PA, et al. Reference values for quantitative left ventricular and left atrial measurements in cardiac computed tomography. Eur Radiol. 2008;18:1625\u201334. \n                    https:\/\/doi.org\/10.1007\/s00330-008-0939-4\n                    \n                  .","journal-title":"Eur Radiol"},{"key":"326_CR16","doi-asserted-by":"publisher","first-page":"42A","DOI":"10.1016\/S0735-1097(87)80447-3","volume":"10","author":"EG Lakatta","year":"1987","unstructured":"Lakatta EG, Mitchell JH, Pomerance A, Rowe GG. Human aging: changes in structure and function. J Am Coll Cardiol. 1987;10:42A\u20137A.","journal-title":"J Am Coll Cardiol"},{"key":"326_CR17","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1161\/01.CIR.63.6.1391","volume":"63","author":"N Reichek","year":"1981","unstructured":"Reichek N, Devereux RB. Left ventricular hypertrophy: relationship of anatomic, echocardiographic and electrocardiographic findings. Circulation. 1981;63:1391\u20138. \n                    https:\/\/doi.org\/10.1161\/01.CIR.63.6.1391\n                    \n                  .","journal-title":"Circulation"},{"key":"326_CR18","unstructured":"Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP. Tipton IH. Report of the Task Group on Reference Man. n.d.:112\u20137."},{"key":"326_CR19","first-page":"423","volume":"23","author":"CR Bardeen","year":"1918","unstructured":"Bardeen CR. Determination of the size of the heart by means of the x-rays. Dev Dyn. 1918;23:423\u201387.","journal-title":"Dev Dyn"},{"key":"326_CR20","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/PAF.0b013e3181875ab2","volume":"30","author":"R Bai","year":"2009","unstructured":"Bai R, Yu X, Wang D, Lv J, Xu G, Lai X. The densities of visceral organs and the extent of pathologic changes. Am J Forensic Med Pathol. 2009;30:148\u201351. \n                    https:\/\/doi.org\/10.1097\/PAF.0b013e3181875ab2\n                    \n                  .","journal-title":"Am J Forensic Med Pathol"},{"key":"326_CR21","first-page":"1","volume":"257","author":"CE Friedman","year":"1951","unstructured":"Friedman CE. Heart volume, myocardial volume and total capacity of the heart cavities in certain chronic heart diseases; a clinic, roentgenologic and patho-anatomic investigation of the problem of cardiac hypertrophy and dilatation and amount of residual blood of the heart. Acta Medica Scand Suppl. 1951;257:1\u2013100.","journal-title":"Acta Medica Scand Suppl"},{"key":"326_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0379-0738(00)00401-1","volume":"119","author":"GL Grandmaison de la","year":"2001","unstructured":"de la Grandmaison GL, Clairand I, Durigon M. Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int. 2001;119:149\u201354.","journal-title":"Forensic Sci Int"},{"key":"326_CR23","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/jmri.21401","volume":"28","author":"SJ Gandy","year":"2008","unstructured":"Gandy SJ, Waugh SA, Nicholas RS, Simpson HJ, Milne W, Houston JG. Comparison of the reproducibility of quantitative cardiac left ventricular assessments in healthy volunteers using different MRI scanners: a multicenter simulation. J Magn Reson Imaging. 2008;28:359\u201365. \n                    https:\/\/doi.org\/10.1002\/jmri.21401\n                    \n                  .","journal-title":"J Magn Reson Imaging"},{"key":"326_CR24","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.echo.2008.07.008","volume":"21","author":"M Takeuchi","year":"2008","unstructured":"Takeuchi M, Nishikage T, Mor-Avi V, Sugeng L, Weinert L, Nakai H, et al. Measurement of left ventricular mass by real-time three-dimensional echocardiography: validation against magnetic resonance and comparison with two-dimensional and m-mode measurements. J Am Soc Echocardiogr. 2008;21:1001\u20135. \n                    https:\/\/doi.org\/10.1016\/j.echo.2008.07.008\n                    \n                  .","journal-title":"J Am Soc Echocardiogr"},{"issue":"1","key":"326_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2478\/sjfs-2018-0002","volume":"24","author":"Jytte Banner","year":"2018","unstructured":"Banner J. SURVIVE: let the dead help the living\u2014an autopsy-based cohort study for mapping risk markers of death among those with severe mental illnesses. Scandinavian journal of forensic science n.d.; 24\/2018:7\u201317. \n                    https:\/\/doi.org\/10.2478\/sjfs-2018-0002\n                    \n                  .","journal-title":"Scandinavian Journal of Forensic Science"},{"key":"326_CR26","first-page":"391","volume":"102","author":"C Basso","year":"2010","unstructured":"Basso C, Burke M, Fornes P, Gallagher PJ, De Gouveia RH, Sheppard M, et al. Guidelines for autopsy investigation of sudden cardiac death. Pathologica. 2010;102:391\u2013404.","journal-title":"Pathologica"},{"key":"326_CR27","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1161\/01.CIR.33.4.558","volume":"33","author":"KE Bove","year":"1966","unstructured":"Bove KE, Rowlands DT, Scott RC. Observations on the assessment of cardiac hypertrophy utilizing a chamber partition technique. Circulation. 1966;33:558\u201368.","journal-title":"Circulation"},{"key":"326_CR28","unstructured":"Lucena J, Garcia-Pavia P, Pulpon LA. Clinico-pathological atlas of cardiovascular diseases. vol. 2015. Springer International Publishing, Switzerland. 362 pages. page 210-215. ISBN 13:978-3319111452."},{"key":"326_CR29","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1161\/01.CIR.68.1.210","volume":"68","author":"NB Schiller","year":"1983","unstructured":"Schiller NB, Ski\u00f4ldebrand CG, Schiller EJ, Mavroudis CC, Silverman NH, Rahimtoola SH, et al. Canine left ventricular mass estimation by two-dimensional echocardiography. Circulation. 1983;68:210\u20136.","journal-title":"Circulation"},{"key":"326_CR30","first-page":"H1181","volume":"258","author":"WJ Manning","year":"1990","unstructured":"Manning WJ, Wei JY, Fossel ET, Burstein D. Measurement of left ventricular mass in rats using electrocardiogram-gated magnetic resonance imaging. Am J Phys Heart Circ Phys. 1990;258:H1181\u20136.","journal-title":"Am J Phys Heart Circ Phys"},{"key":"326_CR31","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1161\/01.CIR.60.5.1104","volume":"60","author":"HL Wyatt","year":"1979","unstructured":"Wyatt HL, Heng MK, Meerbaum S, Hestenes JD, Cobo JM, Davidson RM, et al. Cross-sectional echocardiography. I. Analysis of mathematic models for quantifying mass of the left ventricle in dogs. Circulation. 1979;60:1104\u201313.","journal-title":"Circulation"},{"key":"326_CR32","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1016\/j.jbiomech.2004.10.001","volume":"38","author":"SR Ward","year":"2005","unstructured":"Ward SR, Lieber RL. Density and hydration of fresh and fixed human skeletal muscle. J Biomech. 2005;38:2317\u201320. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2004.10.001\n                    \n                  .","journal-title":"J Biomech"},{"key":"326_CR33","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00330-005-2888-5","volume":"16","author":"KU Juergens","year":"2006","unstructured":"Juergens KU, Fischbach R. Left ventricular function studied with MDCT. Eur Radiol. 2006;16:342\u201357. \n                    https:\/\/doi.org\/10.1007\/s00330-005-2888-5\n                    \n                  .","journal-title":"Eur Radiol"},{"key":"326_CR34","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1177\/0284185114542996","volume":"56","author":"I Dykun","year":"2015","unstructured":"Dykun I, Mahabadi AA, Lehmann N, Bauer M, Moebus S, J\u00f6ckel K-H, et al. Left ventricle size quantification using non-contrast-enhanced cardiac computed tomography--association with cardiovascular risk factors and coronary artery calcium score in the general population: the Heinz Nixdorf recall study. Acta Radiol. 2015;56:933\u201342. \n                    https:\/\/doi.org\/10.1177\/0284185114542996\n                    \n                  .","journal-title":"Acta Radiol"},{"key":"326_CR35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.forsciint.2017.07.006","volume":"278","author":"B Zilg","year":"2017","unstructured":"Zilg B, Thelander G, Giebe B, Druid H. Postmortem blood sampling-comparison of drug concentrations at different sample sites. Forensic Sci Int. 2017;278:296\u2013303. \n                    https:\/\/doi.org\/10.1016\/j.forsciint.2017.07.006\n                    \n                  .","journal-title":"Forensic Sci Int"},{"key":"326_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0379-0738(81)90004-9","volume":"17","author":"A Penttil\u00e4","year":"1981","unstructured":"Penttil\u00e4 A, Laiho K. Autolytic changes in blood cells of human cadavers. II. Morphological studies. Forensic Sci Int. 1981;17:121\u201332.","journal-title":"Forensic Sci Int"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-019-0326-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12880-019-0326-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-019-0326-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T23:05:46Z","timestamp":1586559946000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-019-0326-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["326"],"URL":"https:\/\/doi.org\/10.1186\/s12880-019-0326-4","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"assertion":[{"value":"8 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The next of kin gave informed written or verbal consents that was approved by the National Committee on Danish Health Research Ethics who also approved (20-01-2014) the research protocol (version 2.0 number 1377517).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"29"}}