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Liver function estimation by gadoxetate-enhanced dynamic contrast-enhanced MRI (DCE-MRI) is being established in clinical research, but still rarely used in preclinical trials. We aimed to evaluate feasibility of DCE-MRI indices as translatable biomarkers in a liver fibrosis animal model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Liver fibrosis was induced in Sprague-Dawley rats by thioacetamide (200\u2009mg, 150\u2009mg, and saline for the high-dose, low-dose, and control groups, respectively). Subsequently, DCE-MRI was performed to measure: relative liver enhancement at 3-min (RLE-3), RLE-15, initial area-under-the-curve until 3-min (iAUC-3), iAUC-15, and maximum-enhancement (Emax). The correlation coefficients between these MRI indices and the histologic collagen area, indocyanine green retention at 15-min (ICG-R15), and shear wave elastography (SWE) were calculated. Diagnostic performance to diagnose liver fibrosis was also evaluated by receiver-operating-characteristic (ROC) analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Animal model was successful in that the collagen area of the liver was the largest in the high-dose group, followed by the low-dose group and control group. The correlation between the DCE-MRI indices and collagen area was high for iAUC-15, Emax, iAUC-3, and RLE-3 but moderate for RLE-15 (r, \u2212\u20090.81, \u2212\u20090.81, \u2212\u20090.78, \u2212\u20090.80, and\u2009\u2212\u20090.51, respectively). The DCE-MRI indices showed moderate correlation with ICG-R15: the highest for iAUC-15, followed by iAUC-3, RLE-3, Emax, and RLE-15 (r, \u2212\u20090.65, \u2212\u20090.63, \u2212\u20090.62, \u2212\u20090.58, and\u2009\u2212\u20090.56, respectively). The correlation coefficients between DCE-MRI indices and SWE ranged from \u2212\u20090.59 to \u2212\u20090.28. The diagnostic accuracy of RLE-3, iAUC-3, iAUC-15, and Emax was 100% (AUROC 1.000), whereas those of RLE-15 and SWE were relatively low (AUROC 0.777, 0.848, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Among the gadoxetate-enhanced DCE-MRI indices, iAUC-15 and iAUC-3 might be bidirectional translatable biomarkers between preclinical and clinical research for evaluating histopathologic liver fibrosis and physiologic liver functions in a non-invasive manner.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-019-0378-5","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T13:02:50Z","timestamp":1573822970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gadoxetate-enhanced dynamic contrast-enhanced MRI for evaluation of liver function and liver fibrosis in preclinical trials"],"prefix":"10.1186","volume":"19","author":[{"given":"Jimi","family":"Huh","sequence":"first","affiliation":[]},{"given":"Su Jung","family":"Ham","sequence":"additional","affiliation":[]},{"given":"Young Chul","family":"Cho","sequence":"additional","affiliation":[]},{"given":"Bumwoo","family":"Park","sequence":"additional","affiliation":[]},{"given":"Bohyun","family":"Kim","sequence":"additional","affiliation":[]},{"given":"Chul-Woong","family":"Woo","sequence":"additional","affiliation":[]},{"given":"Yoonseok","family":"Choi","sequence":"additional","affiliation":[]},{"given":"Dong-Cheol","family":"Woo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-5970","authenticated-orcid":false,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"issue":"4","key":"378_CR1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S2468-1253(16)30110-8","volume":"1","author":"P Ramachandran","year":"2016","unstructured":"Ramachandran P, Henderson NC. 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There is no need to receive consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"An author, Kyung Won Kim, is a recipient of a grant (No. 2017R1A2B3011475) from the National Research Foundation of Korea (NRF). An author, Dong-Cheol Woo, is a recipient of a grant (No. 2018R1A2B2007694) from the National Research Foundation of Korea (NRF). Three authors, Su Jung Ham, Young Chul Cho, and Yoonseok Choi, are recipients of a grant (No. HI14C1090) from the Ministry of Health & Welfare, Korea. The other authors have no conflicts of interest to disclosure.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"89"}}