{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:23:10Z","timestamp":1765268590218,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2019,12]]},"abstract":"Abstract<\/jats:title>\n\nBackground<\/jats:title>\nSolid-pseudo papillary neoplasms of pancreas (SPNP) are rare in men and are often misdiagnosed. This study aimed to analyze the clinical and multi-slice computer tomography (MSCT) features of patients with SPNP, and examine the differences between males and females.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nIn this retrospective cohort study, the clinical and imaging data of 29 patients with histolopathologically confirmed SPNP (seven males and 22 females) that underwent radical resection, and underwent preoperative MSCT at the First People\u2019s Hospital of Lianyungang between August 2010 and December 2018 were collected. All MSCT images were reviewed by two radiologists; disagreements were ruled by a third one.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThe median age of the 29 patients with SPNP was 30 (range, 12\u201370) years. The male patients were older than the female patients [median, 56 (28\u201366) vs. 29 (12\u201370), P<\/jats:italic>\u2009=\u20090.012]. The median tumor size was 3.9 (range, 2.0\u20136.4) cm in the male SPNP patients, which was significantly lower than the 7.0 (range, 4.6\u201314.6) cm in the female patients (P<\/jats:italic>\u2009<\u20090.001). The calcification rate of the SPNP was significantly higher in male than in female patients (P<\/jats:italic>\u2009=\u20090.013). The percentage of solid tumor was higher in males than in females (P<\/jats:italic>\u2009=\u20090.036). Capsule, bleeding, and enhancement in the arterial and venous phases were not significantly different between the male and female patients (all P<\/jats:italic>\u2009>\u20090.05).<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nThe imaging features of male SPNP are distinct from those of female patients. In males with pancreatic lesions, MSCT generally shows relatively small lesions with higher percentages of solid components and calcification, with typical enhancement suggesting SPNP.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12880-019-0390-9","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T15:53:12Z","timestamp":1573573992000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical manifestations and multi-slice computed tomography characteristics of solid pseudopapillary neoplasms of the pancreas between males and females"],"prefix":"10.1186","volume":"19","author":[{"given":"Shuguang","family":"Shi","sequence":"first","affiliation":[]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-1802","authenticated-orcid":false,"given":"Chunhong","family":"Hu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"390_CR1","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.jamcollsurg.2005.02.011","volume":"200","author":"T Papavramidis","year":"2005","unstructured":"Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200:965\u201372.","journal-title":"J Am Coll Surg"},{"key":"390_CR2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/1477-7819-11-308","volume":"11","author":"A Yagci","year":"2013","unstructured":"Yagci A, Yakan S, Coskun A, Erkan N, Yildirim M, Yalcin E, et al. Diagnosis and treatment of solid pseudopapillary tumor of the pancreas: experience of one single institution from Turkey. World J Surg Oncol. 2013;11:308.","journal-title":"World J Surg Oncol"},{"key":"390_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11547-013-0327-2","volume":"119","author":"S Hu","year":"2014","unstructured":"Hu S, Huang W, Lin X, Wang Y, Chen KM, Chai W. Solid pseudopapillary tumour of the pancreas: distinct patterns of computed tomography manifestation for male versus female patients. Radiol Med. 2014;119:83\u20139.","journal-title":"Radiol Med"},{"key":"390_CR4","first-page":"1259","volume":"18","author":"S Palmucci","year":"2014","unstructured":"Palmucci S, Cappello G, Trombatore C, Tilocca C, Todaro R, Mauro LA, et al. Cystic pancreatic neoplasms: diagnosis and management emphasizing their imaging features. Eur Rev Med Pharmacol Sci. 2014;18:1259\u201368.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"390_CR5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.5152\/dir.2016.16104","volume":"23","author":"G Anil","year":"2017","unstructured":"Anil G, Zhang J, Al Hamar NE, Nga ME. Solid pseudopapillary neoplasm of the pancreas: CT imaging features and radiologic-pathologic correlation. Diagn Interv Radiol. 2017;23:94\u20139.","journal-title":"Diagn Interv Radiol"},{"key":"390_CR6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/000313481007601011","volume":"76","author":"MY Lin","year":"2010","unstructured":"Lin MY, Stabile BE. Solid pseudopapillary neoplasm of the pancreas: a rare and atypically aggressive disease among male patients. Am Surg. 2010;76:1075\u20138.","journal-title":"Am Surg"},{"key":"390_CR7","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s002689900621","volume":"23","author":"KY Lam","year":"1999","unstructured":"Lam KY, Lo CY, Fan ST. Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature. World J Surg. 1999;23:1045\u201350.","journal-title":"World J Surg"},{"key":"390_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.surg.2007.07.030","volume":"143","author":"MC Machado","year":"2008","unstructured":"Machado MC, Machado MA, Bacchella T, Jukemura J, Almeida JL, Cunha JE. Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery. 2008;143:29\u201334.","journal-title":"Surgery."},{"key":"390_CR9","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s005350200163","volume":"37","author":"K Uchimi","year":"2002","unstructured":"Uchimi K, Fujita N, Noda Y, Kobayashi G, Kimura K, Matsunaga A, et al. Solid cystic tumor of the pancreas: report of six cases and a review of the Japanese literature. J Gastroenterol. 2002;37:972\u201380.","journal-title":"J Gastroenterol"},{"key":"390_CR10","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00428-006-0174-9","volume":"448","author":"Y Takahashi","year":"2006","unstructured":"Takahashi Y, Hiraoka N, Onozato K, Shibata T, Kosuge T, Nimura Y, et al. Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ? Virchows Arch. 2006;448:561\u20139.","journal-title":"Virchows Arch"},{"key":"390_CR11","first-page":"66","volume":"17","author":"DS Klimstra","year":"2000","unstructured":"Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol. 2000;17:66\u201380.","journal-title":"Semin Diagn Pathol"},{"key":"390_CR12","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.crad.2008.04.007","volume":"63","author":"JH Lee","year":"2008","unstructured":"Lee JH, Yu JS, Kim H, Kim JK, Kim TH, Kim KW, et al. Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI. Clin Radiol. 2008;63:1006\u201314.","journal-title":"Clin Radiol"},{"key":"390_CR13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3810\/pgm.2013.03.2634","volume":"125","author":"JK Park","year":"2013","unstructured":"Park JK, Cho EJ, Ryu JK, Kim YT, Yoon YB. Natural history and malignant risk factors of solid pseudopapillary tumors of the pancreas. Postgrad Med. 2013;125:92\u20139.","journal-title":"Postgrad Med"},{"key":"390_CR14","first-page":"18156","volume":"3","author":"Y Zou","year":"2019","unstructured":"Zou Y, Huang Y, Hong B, et al. Comparison of the clinicopathological features of pancreatic solid pseudopapillary neoplasms between males and females: gender does matter. Histol Histopathol. 2019;3:18156.","journal-title":"Histol Histopathol"},{"key":"390_CR15","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/SLA.0000000000000583","volume":"260","author":"CM Kang","year":"2014","unstructured":"Kang CM, Choi SH, Kim SC, Lee WJ, Choi DW, Kim SW, et al. Predicting recurrence of pancreatic solid pseudopapillary tumors after surgical resection: a multicenter analysis in Korea. Ann Surg. 2014;260:348\u201355.","journal-title":"Ann Surg"},{"key":"390_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/his.13376","volume":"72","author":"A Abe","year":"2018","unstructured":"Abe A, Ohishi Y, Miyazaki T, et al. 'Microcystic pattern' should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas. Histopathology. 2018;72:216\u201326.","journal-title":"Histopathology."},{"key":"390_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fcell.2018.00112","volume":"24","author":"JB McCarthy","year":"2018","unstructured":"McCarthy JB, El-Ashry D, Turley EA. Corrigendum: Hyaluronan, cancer-associated fibroblasts and the tumor microenvironment in malignant progression. Front Cell Dev Biol. 2018;24:112.","journal-title":"Front Cell Dev Biol"},{"key":"390_CR18","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2214\/AJR.17.17862","volume":"209","author":"S Javadi","year":"2017","unstructured":"Javadi S, Menias CO, Korivi BR, Shaaban AM, Patnana M, Alhalabi K, et al. Pancreatic calcifications and calcified pancreatic masses: pattern recognition approach on CT. AJR Am J Roentgenol. 2017;209:77\u201387.","journal-title":"AJR Am J Roentgenol"},{"key":"390_CR19","doi-asserted-by":"publisher","first-page":"W178","DOI":"10.2214\/AJR.05.0569","volume":"187","author":"JY Choi","year":"2006","unstructured":"Choi JY, Kim MJ, Kim JH, Kim SH, Lim JS, Oh YT, et al. Solid pseudopapillary tumor of the pancreas: typical and atypical manifestations. AJR Am J Roentgenol. 2006;187:W178\u201386.","journal-title":"AJR Am J Roentgenol"},{"key":"390_CR20","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139013192","volume-title":"Practical body MRI. Protocols, applications and image interpretation","author":"DJ Grand","year":"2012","unstructured":"Grand DJ, Woodfield CA, Mayo-Smith WW. Practical body MRI. Protocols, applications and image interpretation. New York: Cambridge Medicine; 2012."},{"key":"390_CR21","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1148\/rg.314105731","volume":"31","author":"G Low","year":"2011","unstructured":"Low G, Panu A, Millo N, Leen E. Multimodality imaging of neoplastic and nonneoplastic solid lesions of the pancreas. Radiographics. 2011;31:993\u20131015.","journal-title":"Radiographics."},{"key":"390_CR22","first-page":"TC01","volume":"11","author":"S Rai","year":"2017","unstructured":"Rai S, Prabhu S, Rai S, Nirupama M, Adiga DS, Kumar A, et al. Image findings of solid Pseudopapillary neoplasms of the pancreas on multiphasic multidetector CT scan-a single institute experience from southern India. J Clin Diagn Res. 2017;11:TC01\u2013TC5.","journal-title":"J Clin Diagn Res"},{"key":"390_CR23","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1148\/radiol.10092089","volume":"257","author":"JH Baek","year":"2010","unstructured":"Baek JH, Lee JM, Kim SH, Kim SJ, Kim SH, Lee JY, et al. Small (