{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:42Z","timestamp":1772165682385,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Planned Project Grant from the Science and Technology Bureau of Xiamen","award":["3502Z20144052"],"award-info":[{"award-number":["3502Z20144052"]}]},{"name":"the Natural Science Foundation of Fujian Province of China under grant","award":["2018J06018"],"award-info":[{"award-number":["2018J06018"]}]},{"name":"the Fundamental Research Funds for the Central Universities under grant","award":["20720180056"],"award-info":[{"award-number":["20720180056"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung cancer brain metastases are very common and one of the common causes of treatment failure. We aimed to examine the clinical use of chemical exchange saturation transfer (CEST) technology in the evaluation of brain metastases for lung cancer diagnosis and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included26 cases of lung cancer brain metastases, 15 cases of gliomas, and 20 cases with normal tests. The magnetization transfer ratio (MTR;3.5\u2009ppm) image from the GRE-EPI-CEST sequence was analyzed using the ASSET technique and APT technology. The MTR values were measured in the lesion-parenchymal, edema, and non-focus regions, and the MTR image was compared with the conventional MRI. ANOVA and t-test were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The lesion-parenchymal, edema, and non-focus areas in the metastatic-tumor-group were red-yellow, yellow-green, and green-blue, and the MTR values were 3.29\u2009\u00b1\u20091.14%,1.28\u2009\u00b1\u20090.36%,and 1.26\u2009\u00b1\u20090.31%, respectively. However, in the glioma-group, the corresponding areas were red, red-yellow, and green-blue, and the MTR values were 6.29\u2009\u00b1\u20091.58%, 2.87\u2009\u00b1\u20090.65%, and 1.03\u2009\u00b1\u20090.30%, respectively. The MTR values of the corresponding areas in the normal-group were 1.07\u2009\u00b1\u20090.22%,1.04\u2009\u00b1\u20090.23%, and 1.06\u2009\u00b1\u20090.24%, respectively. Traditional MR images are in black-white contrast and no metabolic information is displayed.<\/jats:p>\n                    <jats:p>The MTRvalues of the three regions were significantly different among the three groups. The values were also significantly different between the parenchymal and edema areas in the metastatic-tumor-group. There were significant differences in the MTR values between the non-lesion and edema regions, but there was no significant difference between the edema and non-focus areas. In the glioma-group, there were significant differences in the MTR values between the parenchymal and edema areas, between the parenchymal and non-focus areas, and between the edema and non-focus areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CEST reflects the protein metabolism; therefore, early diagnosis of brain metastases and assessment of the prognosis can be achieved using molecular imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-019-0400-y","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T09:05:57Z","timestamp":1580720757000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preliminary application of 3.0\u2009T magnetic resonance chemical exchange saturation transfer imaging in brain metastasis of lung cancer"],"prefix":"10.1186","volume":"20","author":[{"given":"Yonggui","family":"Yang","sequence":"first","affiliation":[]},{"given":"Xiaobo","family":"Qu","sequence":"additional","affiliation":[]},{"given":"Yihui","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Khan","family":"Afsar","sequence":"additional","affiliation":[]},{"given":"Gen","family":"Yan","sequence":"additional","affiliation":[]},{"given":"Gang","family":"Guo","sequence":"additional","affiliation":[]},{"given":"Shaoyin","family":"Duan","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"400_CR1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/mrm.21653","volume":"60","author":"PZ Sun","year":"2008","unstructured":"Sun PZ, Sorensen AG. 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All subjects were informed of the examination and signed an informed consent before the examination. Written informed consent was obtained from all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All presentations of case reports had consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}