{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T21:23:31Z","timestamp":1749417811991,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81530055"],"award-info":[{"award-number":["81530055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2020A1515010653"],"award-info":[{"award-number":["2020A1515010653"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is an uncommon malignant bladder tumor, and the overall prognosis is poor. Contrast-enhanced ultrasound (CEUS) provides a new effective modality for tumor detection and diagnosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 30-year-old man complained of repeated painless gross haematuria for half a month. Conventional ultrasound demonstrated a hypoechoic solitary lesion with hyperechoic margins measuring 3.4\u2009\u00d7\u20093.1\u2009cm in the anterior wall of the bladder. Superb microvascular imaging (SMI) showed a strong flow signal in the mass. CEUS revealed that the lesion was characterized by hyper-enhancement in the early phase and hypo-enhancement in the late phase. The entire bladder wall was disrupted by homogeneous hyper-enhanced tumor tissue on CEUS. Time-intensity curves (TICs) showed a rapid wash-in with a high maximum signal intensity (SI) and quick wash-out. Finally, partial cystectomy was performed and the pathological examination confirmed the diagnosis of LCNEC with invasion into the whole layer of the bladder wall.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This case suggested that CEUS was a valuable imaging method to detect and diagnose LCNEC in the bladder, and that CEUS can provide information related to the depth of wall invasion and the microvasculature.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12880-020-00447-6","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T17:02:32Z","timestamp":1588525352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[]},{"given":"Ze-Zhen","family":"Su","sequence":"additional","affiliation":[]},{"given":"Ji-Hui","family":"Kang","sequence":"additional","affiliation":[]},{"given":"Xiao-Yan","family":"Xie","sequence":"additional","affiliation":[]},{"given":"Xiao-Hua","family":"Xie","sequence":"additional","affiliation":[]},{"given":"Bo-Wen","family":"Zhuang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"issue":"5","key":"447_CR1","doi-asserted-by":"publisher","first-page":"e375","DOI":"10.1016\/j.clgc.2015.03.005","volume":"13","author":"N Radovi\u0107","year":"2015","unstructured":"Radovi\u0107 N, Turner R, Bacalja J. 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