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The purpose of this study was to compare the suitability of two software packages with different technical principles for analysis of rotation and torsion of the left ventricle during systole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A group of hypertrophic cardiomyopathy (HCM) patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200914, age 43\u2009\u00b1\u200911\u2009years), mutation carriers without hypertrophy (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200910, age 34\u2009\u00b1\u200913\u2009years), and healthy relatives (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200912, age 43\u2009\u00b1\u200917\u2009years) underwent a cardiovascular magnetic resonance examination, including spatial modulation of magnetization tagging sequences in basal and apical planes of the left ventricle. The tagging images were analyzed offline using a harmonic phase image analysis method with Gabor filtering and a non-rigid registration-based free-form deformation technique. Left-ventricle rotation and torsion scores were obtained from end-diastole to end-systole with both software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis was successful in all cases with both software applications. End-systolic torsion values between the study groups were not statistically different with either software. End-systolic apical rotation, end-systolic basal rotation, and end-systolic torsion were consistently higher when analyzed with non-rigid registration than with harmonic phase-based analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.0001). End-systolic rotation and torsion values had significant correlations between the two software (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.0001), most significant in the apical plane.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When comparing absolute values of rotation and torsion between different individuals, software-specific reference values are required. Harmonic phase flow with Gabor filtering and non-rigid registration-based methods can both be used reliably in the analysis of systolic rotation and torsion patterns of the left ventricle.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-020-00473-4","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T03:53:05Z","timestamp":1593575585000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rotation and torsion of the left ventricle with cardiovascular magnetic resonance tagging: comparison of two analysis methods"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-3867","authenticated-orcid":false,"given":"Lauri","family":"Lehmonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Jalanko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Tarkiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touko","family":"Kaasalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Kuusisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Lauerma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sauli","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"10","key":"473_CR1","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/j.jacc.2006.08.030","volume":"48","author":"PP Sengupta","year":"2006","unstructured":"Sengupta PP, Korinek J, Belohlavek M, Narula J, Vannan MA, Jahangir A, et al. 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