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Indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging and cone beam CT (CBCT) have advantages for intraoperative use. However, limited literature exists regarding their use in head and neck cancer SLNB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective, non-randomized study using a rabbit oral cavity VX2 squamous cell carcinoma model (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910) which develops lymph node metastasis. Pre-operatively, images were acquired by MicroCT. During surgery, CBCT and NIR fluorescence imaging of ICG was used to map and guide the SLNB resection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraoperative use of ICG to guide fluorescence resection resulted in identification of all lymph nodes identified by pre-operative CT. CBCT was useful for near real time intraoperative imaging and 3D reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pre-clinical study further demonstrates the technical feasibility, limitations and advantages of intraoperative NIR-guided ICG imaging for SLN identification as a complementary method during head and neck surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-020-00507-x","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:03:15Z","timestamp":1600074195000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sentinel lymph node mapping using ICG fluorescence and cone beam CT \u2013 a feasibility study in a rabbit model of oral cancer"],"prefix":"10.1186","volume":"20","author":[{"given":"Nidal","family":"Muhanna","sequence":"first","affiliation":[]},{"given":"Harley H. 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