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For each scan, three AC maps were generated: ZTE\u2013AC, atlas-AC and reference standard CT-AC. Maximum and mean standardised uptake values (SUV) were measured in the hotspot, mirror region and frontal cortex. In postoperative patients (n\u2009=\u20098), SUV values were additionally obtained adjacent to the metal implant and mirror region. Standardised uptake ratios (SUR) hotspot\/mirror, hotspot\/cortex and metal\/mirror were then calculated and analysed with Bland\u2013Altman, Pearson correlation and intraclass correlation reliability in the overall group and subgroups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>ZTE\u2013AC demonstrated narrower SD and 95% CI (Bland\u2013Altman)\u00a0than atlas-AC in the hotspot analysis for all groups (ZTE overall\u2009\u2264\u20092.84, \u2212 1.41 to 1.70; metal\u2009\u2264\u20091.67, \u2212 3.00 to 2.20; non-metal\u2009\u2264\u20093.04, \u2212 0.96 to 3.38; Atlas overall\u2009\u2264\u20094.56, \u2212 1.05 to 3.83; metal\u2009\u2264\u20093.87, \u2212 3.81 to 4.64; non-metal\u2009\u2264\u20094.90, \u2212 1.68 to 5.86). The mean bias for both ZTE\u2013AC and atlas-AC was\u2009\u2264\u20092.4% compared to CT-AC. In the metal region analysis, ZTE\u2013AC demonstrated a narrower mean bias range\u2014closer to zero\u2014and narrower SD and 95% CI (ZTE 0.21\u20130.48,\u2009\u2264\u20092.50, \u2212 1.70 to 2.57; Atlas 0.56\u20131.54,\u2009\u2264\u20094.01, \u2212 1.81 to 4.89). The mean bias for both ZTE\u2013AC and atlas-AC was within 1.6%. A perfect correlation (Pearson correlation)\u00a0was found for both ZTE\u2013AC and atlas-AC compared to CT-AC in the hotspot and metal analysis (ZTE \u03c1 1.00, p\u2009&lt;\u20090.0001; atlas \u03c1 1.00, p\u2009&lt;\u20090.0001). An almost perfect intraclass correlation coefficient for absolute agreement was found between Atlas-, ZTE and CT maps for maxSUR and meanSUR values in all the analyses (ICC\u2009&gt;\u20090.99).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both ZTE and atlas-AC showed a good performance against CT-AC in patients with brain tumour.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-020-00526-8","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T13:03:07Z","timestamp":1606309387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of PET\/MRI attenuation correction methodology in the study of brain tumours"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-3248","authenticated-orcid":false,"given":"Francesca","family":"De Luca","sequence":"first","affiliation":[]},{"given":"Martin","family":"Bolin","sequence":"additional","affiliation":[]},{"given":"Lennart","family":"Blomqvist","sequence":"additional","affiliation":[]},{"given":"Cecilia","family":"Wassberg","sequence":"additional","affiliation":[]},{"given":"Heather","family":"Martin","sequence":"additional","affiliation":[]},{"given":"Anna","family":"Falk Delgado","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"issue":"5","key":"526_CR1","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1002\/jmri.25711","volume":"46","author":"EC Ehman","year":"2017","unstructured":"Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PEZ, et al. 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Karolinska University Hospital has several research agreements with different radiology vendors. No money has been paid from any of these vendors directly to the authors for this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}