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All subjects underwent head MRI examination during resting state. A voxel-based analysis of fractional amplitude of low frequency fluctuation (fALFF) maps between IBS-D and HC was performed using a two-sample\n                      <jats:italic>t<\/jats:italic>\n                      -test. The relationship between the fALFF values in abnormal brain regions and the scores of Symptom Severity Scale (IBS-SSS) were analyzed using Pearson correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with HC, IBS-D patients had lower fALFF values in the left medial superior frontal gyrus and higher fALFF values in the left hippocampus and right precuneus. There was a positive correlation between the duration scores of IBS-SSS and fALFF values in the right precuneus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The altered fALFF values in the medial superior frontal gyri, left hippocampus and right precuneus revealed changes of intrinsic neuronal activity, further revealing the abnormality of gut-brain axis of IBS-D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-020-00541-9","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T13:03:54Z","timestamp":1609938234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intrinsic brain abnormalities of irritable bowel syndrome with diarrhea: a preliminary resting-state functional magnetic resonance imaging study"],"prefix":"10.1186","volume":"21","author":[{"given":"Weiqun","family":"Ao","sequence":"first","affiliation":[]},{"given":"Yougen","family":"Cheng","sequence":"additional","affiliation":[]},{"given":"Mingxian","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Fuquan","family":"Wei","sequence":"additional","affiliation":[]},{"given":"Guangzhao","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Yongyu","family":"An","sequence":"additional","affiliation":[]},{"given":"Fan","family":"Mao","sequence":"additional","affiliation":[]},{"given":"Xiandi","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Guoqun","family":"Mao","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"issue":"1","key":"541_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/j.gastro.2014.04.034","volume":"146","author":"EP Halmos","year":"2014","unstructured":"Halmos EP, Power VA, Shepherd SJ, et al. 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