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The five consecutive multi-b DWI with different b-value protocols (0\u20133500\u2009s\/mm<jats:sup>2<\/jats:sup>) were performed in 22 male healthy volunteers on a 3.0-T MRI system. The IVIM parameters from normal white matter (WM) and gray matter (GM) including slow diffusion coefficient (D), fast perfusion coefficient (D*) and perfusion fraction (f) were compared for differences among defined groups with different IVIM protocols by one-way ANOVA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The D* and f value of WM or GM in groups with less low b-values distribution (less than or equal to 5 b-values) were significantly lower than ones in any other group with more low b-values distribution (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.05), but no significant differences among groups with more low b-values distribution (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). In addition, no significant differences in the D, D* and f value of WM or GM were found between group with one and more NEX of low b-values distribution (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). IVIM parameters in normal WM and GM strongly depended on the choice of the high b-value upper limit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Metrics of IVIM parameters can be affected by low and high b value distribution. Eight low b-values distribution with high b-value upper limit of 800\u20131000\u2009s\/mm<jats:sup>2<\/jats:sup> may be the relatively proper set when performing brain IVIM studies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-020-0419-0","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T16:02:47Z","timestamp":1581350567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?"],"prefix":"10.1186","volume":"20","author":[{"given":"Yu-Chuan","family":"Hu","sequence":"first","affiliation":[]},{"given":"Lin-Feng","family":"Yan","sequence":"additional","affiliation":[]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[]},{"given":"Shi-Jun","family":"Duan","sequence":"additional","affiliation":[]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Gang-Feng","family":"Li","sequence":"additional","affiliation":[]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Xiao-Cheng","family":"Wei","sequence":"additional","affiliation":[]},{"given":"Dan-Dan","family":"Zheng","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-9803","authenticated-orcid":false,"given":"Guang-Bin","family":"Cui","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"issue":"2","key":"419_CR1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1148\/radiology.168.2.3393671","volume":"168","author":"D Le Bihan","year":"1988","unstructured":"Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. 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