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This report presents the MRI findings with apparent diffusion coefficient (ADC) value in an exceedingly rare primary marginal zone B-cell lymphoma (MZBCL) of the cavernous sinus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>The case in this study is a 59-year-old immunocompetent male patient with a 2-month history of right ptosis and blurred vision. Right third cranial nerve palsy and binocular diplopia were observed upon neurological examination. Preoperative brain CT showed an extra-axial enhancing mass lesion in the right cavernous sinus. On MRI, ipsilateral internal carotid arterial encasement was noted without causing stenosis of the vessel. Isointense signal on T1-weighted and T2-weighted images, homogeneous contrast enhancement, and diffusion restriction were also observed. The mean ADC value of the tumor is 0.64\u2009\u00d7\u200910<jats:sup>\u20133<\/jats:sup>\u00a0mm<jats:sup>2<\/jats:sup>\/s (b value\u2009=\u20091000\u00a0s\/mm<jats:sup>2<\/jats:sup>). Subtotal resection of the tumor was performed, and improvement of clinical symptoms were observed. The pathologic diagnosis of MZBCL was established by immunohistochemical examinations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Primary MZBCL of the cavernous sinus is exceedingly rare, and preoperative confirmation poses a major challenge with CT and conventional MRI only. In this case, preoperative quantitative ADC value is shown to offer valuable additional information in the diagnostic process.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-021-00556-w","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T20:30:21Z","timestamp":1613161821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary marginal zone B-cell lymphoma of the cavernous sinus: a case report and review of the literature"],"prefix":"10.1186","volume":"21","author":[{"given":"Cheng-Chun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Kun","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0721-9606","authenticated-orcid":false,"given":"Ching-Chung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"issue":"8","key":"556_CR1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0025-6196(12)61228-2","volume":"64","author":"BP O'Neill","year":"1989","unstructured":"O\u2019Neill BP, Illig JJ. 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Written consent was waived because the retrospective nature of this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent was waived because the retrospective nature of this study meant that healthcare of included subject was not affected. The personal information was anonymized and de-identified.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors hereby declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25"}}