{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:34:57Z","timestamp":1773192897806,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n Background<\/jats:title>\n Dynamic PET with kinetic modeling was reported to be potentially helpful in the assessment of hepatic malignancy. In this study, a kinetic modeling analysis was performed on hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) from dynamic FDG positron emission tomography\/computer tomography (PET\/CT) scans.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n A reversible two-tissue compartment model with dual blood input function, which takes into consideration the blood supply from both hepatic artery and portal vein, was used for accurate kinetic modeling of liver dynamic 18<\/jats:sup>F-FDG PET imaging. The blood input functions were directly measured as the mean values over the VOIs on descending aorta and portal vein respectively. And the contribution of hepatic artery to the blood input function was optimization-derived in the process of model fitting. The kinetic model was evaluated using dynamic PET data acquired on 24 patients with identified hepatobiliary malignancy. 38 HCC or ICC identified lesions and 24 healthy liver regions were analyzed.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n Results showed significant differences in kinetic parameters $${K}_{1}-{k}_{4}$$<\/jats:tex-math>\n \n \n K<\/mml:mi>\n 1<\/mml:mn>\n <\/mml:msub>\n -<\/mml:mo>\n \n k<\/mml:mi>\n 4<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>, blood supplying fraction $${f}_{A}$$<\/jats:tex-math>\n \n f<\/mml:mi>\n A<\/mml:mi>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>, and metabolic rate constant $${K}_{i}$$<\/jats:tex-math>\n \n K<\/mml:mi>\n i<\/mml:mi>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> between malignant lesions and healthy liver tissue. And significant differences were also observed in $${K}_{1}$$<\/jats:tex-math>\n \n K<\/mml:mi>\n 1<\/mml:mn>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>, $${k}_{3}$$<\/jats:tex-math>\n \n k<\/mml:mi>\n 3<\/mml:mn>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>, $${f}_{A}$$<\/jats:tex-math>\n \n f<\/mml:mi>\n A<\/mml:mi>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and $${K}_{i}$$<\/jats:tex-math>\n \n K<\/mml:mi>\n i<\/mml:mi>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> between HCC and ICC lesions. Further investigations of the effect of SUV measurements on the derived kinetic parameters were conducted. And results showed comparable effectiveness of the kinetic modeling using either SUVmean or SUVmax measurements.<\/jats:p>\n <\/jats:sec>\n Conclusions<\/jats:title>\n Dynamic 18F-FDG PET imaging with optimization-derived hepatic artery blood supply fraction dual-blood input function kinetic modeling can effectively distinguish malignant lesions from healthy liver tissue, as well as HCC and ICC lesions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12880-021-00623-2","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T20:02:26Z","timestamp":1621972946000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic 18F-FDG PET imaging of liver lesions: evaluation of a two-tissue compartment model with dual blood input function"],"prefix":"10.1186","volume":"21","author":[{"given":"Jingnan","family":"Wang","sequence":"first","affiliation":[]},{"given":"Yunwen","family":"Shao","sequence":"additional","affiliation":[]},{"given":"Bowei","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Xuezhu","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Barbara Katharina","family":"Geist","sequence":"additional","affiliation":[]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[]},{"given":"Haitao","family":"Zhao","sequence":"additional","affiliation":[]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[]},{"given":"Haiyan","family":"Ding","sequence":"additional","affiliation":[]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Li","family":"Huo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"issue":"1","key":"623_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. 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Written informed consent to undergo 18<\/sup>F-FDG PET\/CT imaging was obtained from all patients, and the consent form and study protocol were approved by the Ethical Committee of PUMCH (IRB protocol # ZS-1238).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}