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This study seeks to elucidate the correlation between the apparent diffusion coefficient (ADC) value and some selected clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 101 Chinese patients with MM who had undergone WB-DWI from May 2017 to May 2019 were enrolled in this study. The ADC values of the MM lesions and the clinical parameters were quantified at the first (baseline) visit and after four-course induction chemotherapy. Multiple linear regression and logistic analyses were carried out to find the implicit inherent relationships within the patients\u2019 data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The paired Wilcoxon test showed that the ADC values at the baseline visit (ADC\n                      <jats:sub>0<\/jats:sub>\n                      ) were significantly lower than the values after four-course induction chemotherapy (ADC\n                      <jats:sub>4 c<\/jats:sub>\n                      ) (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001), including different therapeutic responses. The Revised International Staging System (RISS) stage, type of MM, and \u03b22-microglobulin (\u03b22-MG) were predictors of clinically significant increases or decreases in the ADC values (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Multiple linear regression showed that the ADC\n                      <jats:sub>0<\/jats:sub>\n                      was negatively associated with \u03b22-MG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and immunoglobulin heavy chain gene rearrangement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), while the RISS Stage III (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), type IgG \u03bb (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and albumin were negatively associated with ADC\n                      <jats:sub>4 c<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). The impacts of the therapeutic response were associated with ADC\n                      <jats:sub>0<\/jats:sub>\n                      and immunoglobulin heavy chain gene rearrangement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ADC values of WB-DWI may be associated with clinical parameters of MM including the fluorescence in situ hybridization result, and may be useful in the prognosis of patients with MM.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial Registration<\/jats:italic>\n                      : ChiCTR2000029587\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-021-00631-2","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T05:05:30Z","timestamp":1623128730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlations between apparent diffusion coefficient values of WB-DWI and clinical parameters in multiple myeloma"],"prefix":"10.1186","volume":"21","clinical-trial-number":[{"clinical-trial-number":"chictr2000029587","registry":"10.18810\/chictr"}],"author":[{"given":"Bei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyang","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zining","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwu","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"issue":"9","key":"631_CR1","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1158\/1535-7163.MCT-18-1216","volume":"18","author":"T Kodama","year":"2019","unstructured":"Kodama T, Kochi Y, Nakai W, et al. 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The number of the approval document is 2020-006.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}