{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:03:28Z","timestamp":1780592608138,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 61871276"],"award-info":[{"award-number":["No. 61871276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Capital's Funds for Health Improvement and Research","award":["No. 2018-2-2023"],"award-info":[{"award-number":["No. 2018-2-2023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Simultaneous multislice diffusion-weighted imaging (SMS-DWI) has been used to reduce image acquisition time. The purpose of this study was to investigate the feasibility of diffusion kurtosis imaging (DKI) based on the SMS technique in the liver and the influence of this method compared with that of conventional DWI sequences on image quality and DKI-derived quantitative parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty volunteers underwent SMS-DWI sequences with acceleration factors of 2 and 3 (SMS2-DWI, SMS3-DWI) and conventional DWI (C-DWI) of the liver with three b-values (50, 800, 2000\u00a0s\/mm<jats:sup>2<\/jats:sup>) in a 3T system. Qualitative image quality parameters and quantitative measurements of the signal-to-noise ratio (SNR), mean kurtosis (MK), mean apparent diffusivity (MD) and apparent diffusion coefficient (ADC) for the liver were compared between the three sequences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The scan times of C-DWI, SMS2-DWI, and SMS3-DWI were 4\u00a0min 11\u00a0s, 2\u00a0min 2\u00a0s, and 1\u00a0min 34\u00a0s, respectively. For all image quality parameters, there were no significant differences observed between C-DWI and SMS2-DWI (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) in the images with b-values of 800 and 2000\u00a0s\/mm<jats:sup>2<\/jats:sup>. C-DWI and SMS2-DWI exhibited better scores than SMS3-DWI (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) in the images with b-values of 2000\u00a0s\/mm<jats:sup>2<\/jats:sup>. In the images with b-values of 800\u00a0s\/mm<jats:sup>2<\/jats:sup>, C-DWI and SMS2-DWI exhibited better scores than SMS3-DWI for artefacts and overall image quality (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and C-DWI exhibited better scores than SMS3-DWI for the visibility of intrahepatic vessels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant differences in the sharpness of the right lobe edge (<jats:italic>p<\/jats:italic>\u2009=\u20090.144), conspicuity of the left lobe (<jats:italic>p<\/jats:italic>\u2009=\u20090.370) or visibility of intrahepatic vessels (<jats:italic>p<\/jats:italic>\u2009=\u20090.109) between SMS2-DWI and SMS3-DWI. There were no significant differences in the sharpness of the right lobe edge (<jats:italic>p<\/jats:italic>\u2009=\u20090.066) or conspicuity of the left lobe (<jats:italic>p<\/jats:italic>\u2009=\u20090.131) between C-DWI and SMS3-DWI. For the b-value of 800\u00a0s\/mm<jats:sup>2<\/jats:sup>, there were no statistically significant differences between SMS2-DWI and C-DWI (<jats:italic>p<\/jats:italic>\u2009=\u20091.000) or between SMS2-DWI and SMS3-DWI (<jats:italic>p<\/jats:italic>\u2009=\u20090.059), whereas SMS3-DWI had a significantly lower SNR than C-DWI (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). For the DKI-derived parameters (MK and MD) and ADC values, there were no significant differences between the three sequences (MK, <jats:italic>p<\/jats:italic>\u2009=\u20090.606; MD, <jats:italic>p<\/jats:italic>\u2009=\u20090.831; ADC, <jats:italic>p\u2009=<\/jats:italic>\u20090.264).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>SMS-DWI with an acceleration factor of 2 is feasible for the liver, resulting in considerable reductions in scan time while maintaining similar image quality, comparable DKI parameters and ADC values compared with those of C-DWI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-021-00661-w","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T16:04:46Z","timestamp":1631203486000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Feasibility study of simultaneous multislice diffusion kurtosis imaging with different acceleration factors in the liver"],"prefix":"10.1186","volume":"21","author":[{"given":"Hui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Han","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"6","key":"661_CR1","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/mrm.20508","volume":"53","author":"JH Jensen","year":"2005","unstructured":"Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. 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All methods were carried out in accordance with relevant guidelines and regulations, and written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"132"}}