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The cases were divided into malignant and benign groups according to the pathological results. CT perfusion parameters, such as Median, Mean, Standard deviation (Std), Q10, Q25, Q50, Q75, Q90 of pulmonary artery perfusion (PAP), bronchial artery perfusion (BAP), perfusion index (PI) and arterial enhancement fraction (AEF) were obtained by performing computed tomography perfusion imaging (CTPI). Computed tomography perfusion (CTP) parameters were compared between malignant and benign lesions. The receiver operating characteristic (ROC) curve was used to assess the diagnostic efficiency of CTP parameters in diagnosing malignant lesions. The correlations between CTP parameters with MVD and VEGF were analysed in 36 lung cancer patients who had extra sections be used for immunohistochemistry staining of CD34 and VEGF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>BAP (Mean, Std, Q90) and PI Std of benign lesions were higher than malignant lesions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and PAP (Q10, Q25), PI (Median, Mean, Q10, Q25, Q50) of malignant lesions were higher than the benign (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The area under the ROC curve of PI Mean, PI Q10 and PI Std was 0.722 (95% CI\u2009=\u2009[0.595\u20130.845]), 0.728 (95% CI\u2009=\u2009[0.612\u20130.844]) and 0.717 (95% CI\u2009=\u2009[0.598\u20130.835]) respectively. Partial perfusion parameters of BAP and AEF Q10 were positively correlated with MVD (<jats:italic>p<\/jats:italic> value range is\u2009&lt;\u20090.001\u20130.037, \u03c1 value range is 0.483\u20130.683), and partial perfusion parameters of PI were negatively correlated with MVD (<jats:italic>p<\/jats:italic> value range is 0.001\u20130.041,\u03c1value range is \u2212\u20090.523\u2013\u2212\u20090.343). Partial perfusion parameters of BAP and AEF Q10 were positively correlated with VEGF (<jats:italic>p<\/jats:italic> value range is 0.001\u20130.016, \u03c1value range is 0.398\u20130.570), meanwhile some perfusion parameters of PAP and PI were negatively correlated with VEGF (<jats:italic>p<\/jats:italic> value range is 0.001\u20130.040, \u03c1 value range is \u2212\u20090.657\u20130.343).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Quantitative parameters of dynamic triple-phase enhanced CT can provide diagnostic basis for the differentiation of lung lesions, and there were connection with tumor angiogenesis and vascular endothelial growth factor expression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-021-00692-3","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T07:02:54Z","timestamp":1635577374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary lesions: correlative study of dynamic triple-phase enhanced CT perfusion imaging with tumor angiogenesis and vascular endothelial growth factor expression"],"prefix":"10.1186","volume":"21","author":[{"given":"Mingyue","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"issue":"1","key":"692_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. 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