{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:44Z","timestamp":1772165684201,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 3D U-Net model has been proved to perform well in the automatic organ segmentation. The aim of this study is to evaluate the feasibility of the 3D U-Net algorithm for the automated detection and segmentation of lymph nodes (LNs) on pelvic diffusion-weighted imaging (DWI) images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 393 DWI images of patients suspected of having prostate cancer (PCa) between January 2019 and December 2020 were collected for model development. Seventy-seven DWI images from another group of PCa patients imaged between January 2021 and April 2021 were collected for temporal validation. Segmentation performance was assessed using the Dice score, positive predictive value (PPV), true positive rate (TPR), and volumetric similarity (VS), Hausdorff distance (HD), the Average distance (AVD), and the Mahalanobis distance (MHD) with manual annotation of pelvic LNs as the reference. The accuracy with which the suspicious metastatic LNs (short diameter\u2009&gt;\u20090.8\u00a0cm) were detected was evaluated using the area under the curve (AUC) at the patient level, and the precision, recall, and F1-score were determined at the lesion level. The consistency of LN staging on an hold-out test dataset between the model and radiologist was assessed using Cohen\u2019s kappa coefficient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the testing set used for model development, the Dice score, TPR, PPV, VS, HD, AVD and MHD values for the segmentation of suspicious LNs were 0.85, 0.82, 0.80, 0.86, 2.02 (mm), 2.01 (mm), and 1.54 (mm) respectively. The precision, recall, and F1-score for the detection of suspicious LNs were 0.97, 0.98 and 0.97, respectively. In the temporal validation dataset, the AUC of the model for identifying PCa patients with suspicious LNs was 0.963 (95% CI: 0.892\u20130.993). High consistency of LN staging (Kappa\u2009=\u20090.922) was achieved between the model and expert radiologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 3D U-Net algorithm can accurately detect and segment pelvic LNs based on DWI images.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-021-00703-3","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T08:02:42Z","timestamp":1636790562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Development and validation of the 3D U-Net algorithm for segmentation of pelvic lymph nodes on diffusion-weighted images"],"prefix":"10.1186","volume":"21","author":[{"given":"Xiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaonan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingpu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"issue":"1","key":"703_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.juro.2010.03.039","volume":"184","author":"C von Bodman","year":"2010","unstructured":"von Bodman C, Godoy G, Chade DC, Cronin A, Tafe LJ, Fine SW, Laudone V, Scardino PT, Eastham JA. Predicting biochemical recurrence-free survival for patients with positive pelvic lymph nodes at radical prostatectomy. J Urol. 2010;184(1):143\u20138.","journal-title":"J Urol"},{"issue":"66","key":"703_CR2","doi-asserted-by":"publisher","first-page":"110625","DOI":"10.18632\/oncotarget.22610","volume":"8","author":"YJ Kim","year":"2017","unstructured":"Kim YJ, Song C, Eom KY, Kim IA, Kim JS. Lymph node ratio determines the benefit of adjuvant radiotherapy in pathologically 3 or less lymph node-positive prostate cancer after radical prostatectomy: a population-based analysis with propensity-score matching. Oncotarget. 2017;8(66):110625\u201334.","journal-title":"Oncotarget"},{"issue":"4","key":"703_CR3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.eururo.2016.08.003","volume":"71","author":"N Mottet","year":"2017","unstructured":"Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, Fossati N, Gross T, Henry AM, Joniau S, et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol. 2017;71(4):618\u201329.","journal-title":"Eur Urol"},{"issue":"2","key":"703_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.eururo.2013.05.033","volume":"66","author":"G Gakis","year":"2014","unstructured":"Gakis G, Boorjian SA, Briganti A, Joniau S, Karazanashvili G, Karnes RJ, Mattei A, Shariat SF, Stenzl A, Wirth M, et al. The role of radical prostatectomy and lymph node dissection in lymph node-positive prostate cancer: a systematic review of the literature. Eur Urol. 2014;66(2):191\u20139.","journal-title":"Eur Urol"},{"issue":"6","key":"703_CR5","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/bju.14892","volume":"124","author":"Y Hou","year":"2019","unstructured":"Hou Y, Bao ML, Wu CJ, Zhang J, Zhang YD, Shi HB. A machine learning-assisted decision-support model to better identify patients with prostate cancer requiring an extended pelvic lymph node dissection. BJU Int. 2019;124(6):972\u201383.","journal-title":"BJU Int"},{"issue":"1","key":"703_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/jmri.22790","volume":"35","author":"D Yakar","year":"2012","unstructured":"Yakar D, Debats OA, Bomers JG, Schouten MG, Vos PC, van Lin E, F\u00fctterer JJ, Barentsz JO. Predictive value of MRI in the localization, staging, volume estimation, assessment of aggressiveness, and guidance of radiotherapy and biopsies in prostate cancer. J Magn Reson Imaging. 2012;35(1):20\u201331.","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"703_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1148\/radiol.2019181931","volume":"292","author":"R Perez-Lopez","year":"2019","unstructured":"Perez-Lopez R, Tunariu N, Padhani AR, Oyen WJG, Fanti S, Vargas HA, Omlin A, Morris MJ, de Bono J, Koh DM. Imaging diagnosis and follow-up of advanced prostate cancer: clinical perspectives and state of the art. Radiology. 2019;292(2):273\u201386.","journal-title":"Radiology"},{"issue":"4","key":"703_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.crad.2007.05.022","volume":"63","author":"AM H\u00f6vels","year":"2008","unstructured":"H\u00f6vels AM, Heesakkers RA, Adang EM, Jager GJ, Strum S, Hoogeveen YL, Severens JL, Barentsz JO. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol. 2008;63(4):387\u201395.","journal-title":"Clin Radiol"},{"issue":"3","key":"703_CR9","doi-asserted-by":"publisher","first-page":"W95","DOI":"10.2214\/AJR.17.18481","volume":"210","author":"S Woo","year":"2018","unstructured":"Woo S, Suh CH, Kim SY, Cho JY, Kim SH. The diagnostic performance of mri for detection of lymph node metastasis in bladder and prostate cancer: an updated systematic review and diagnostic meta-analysis. AJR Am J Roentgenol. 2018;210(3):W95-w109.","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"703_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11934-015-0505-y","volume":"16","author":"S Sankineni","year":"2015","unstructured":"Sankineni S, Brown AM, Fascelli M, Law YM, Pinto PA, Choyke PL, Turkbey B. Lymph node staging in prostate cancer. Curr Urol Rep. 2015;16(5):30.","journal-title":"Curr Urol Rep"},{"key":"703_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.media.2017.07.005","volume":"42","author":"G Litjens","year":"2017","unstructured":"Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, van der Laak J, van Ginneken B, S\u00e1nchez CI. A survey on deep learning in medical image analysis. Med Image Anal. 2017;42:60\u201388.","journal-title":"Med Image Anal"},{"key":"703_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-030-33128-3_1","volume":"1213","author":"HP Chan","year":"2020","unstructured":"Chan HP, Samala RK, Hadjiiski LM, Zhou C. Deep learning in medical image analysis. Adv Exp Med Biol. 2020;1213:3\u201321.","journal-title":"Adv Exp Med Biol"},{"key":"703_CR13","doi-asserted-by":"crossref","unstructured":"Cuocolo R, Comelli A, Stefano A, Benfante V, Dahiya N, Stanzione A, Castaldo A, De Lucia DR, Yezzi A, Imbriaco M. Deep learning whole-gland and zonal prostate segmentation on a public MRI dataset. J Magn Reson Imaging 2021.","DOI":"10.1002\/jmri.27585"},{"key":"703_CR14","doi-asserted-by":"crossref","unstructured":"Comelli A, Coronnello C, Dahiya N, Benfante V, Palmucci S, Basile A, Vancheri C, Russo G, Yezzi A, Stefano A. Lung segmentation on high-resolution computerized tomography images using deep learning: a preliminary step for radiomics studies. J Imaging 2020;6(11).","DOI":"10.3390\/jimaging6110125"},{"key":"703_CR15","doi-asserted-by":"crossref","unstructured":"Roth HR, Lu L, Seff A, Cherry KM, Hoffman J, Wang S, Liu J, Turkbey E, Summers RM: A new 2.5D representation for lymph node detection using random sets of deep convolutional neural network observations. Medical image computing and computer-assisted intervention : MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention 2014, 17(Pt 1):520\u2013527.","DOI":"10.1007\/978-3-319-10404-1_65"},{"issue":"5","key":"703_CR16","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1109\/TMI.2015.2482920","volume":"35","author":"HR Roth","year":"2016","unstructured":"Roth HR, Lu L, Liu J, Yao J, Seff A, Cherry K, Kim L, Summers RM. Improving computer-aided detection using convolutional neural networks and random view aggregation. IEEE Trans Med Imaging. 2016;35(5):1170\u201381.","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"703_CR17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/cpf.12666","volume":"41","author":"P Borrelli","year":"2021","unstructured":"Borrelli P, Larsson M, Ul\u00e9n J, Enqvist O, Tr\u00e4g\u00e5rdh E, Poulsen MH, Mortensen MA, Kj\u00f6lhede H, H\u00f8ilund-Carlsen PF, Edenbrandt L. Artificial intelligence-based detection of lymph node metastases by PET\/CT predicts prostate cancer-specific survival. Clin Physiol Funct Imaging. 2021;41(1):62\u20137.","journal-title":"Clin Physiol Funct Imaging"},{"issue":"3","key":"703_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00259-019-04606-y","volume":"47","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Gafita A, Vollnberg B, Tetteh G, Haupt F, Afshar-Oromieh A, Menze B, Eiber M, Rominger A, Shi K. Deep neural network for automatic characterization of lesions on (68)Ga-PSMA-11 PET\/CT. Eur J Nucl Med Mol Imaging. 2020;47(3):603\u201313.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"11","key":"703_CR19","doi-asserted-by":"publisher","first-page":"6178","DOI":"10.1118\/1.3654162","volume":"38","author":"OA Debats","year":"2011","unstructured":"Debats OA, Litjens GJ, Barentsz JO, Karssemeijer N, Huisman HJ. Automated 3-dimensional segmentation of pelvic lymph nodes in magnetic resonance images. Med Phys. 2011;38(11):6178\u201387.","journal-title":"Med Phys"},{"key":"703_CR20","doi-asserted-by":"crossref","unstructured":"Cicek O, Abdulkadir A, Lienkamp SS, Brox T, Ronneberger O: 3D U-Net: learning dense volumetric segmentation from sparse annotation. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016 19th International Conference Proceedings: LNCS 9901 2016:424\u2013432.","DOI":"10.1007\/978-3-319-46723-8_49"},{"key":"703_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12880-015-0068-x","volume":"15","author":"AA Taha","year":"2015","unstructured":"Taha AA, Hanbury A. Metrics for evaluating 3D medical image segmentation: analysis, selection, and tool. BMC Med Imaging. 2015;15:29.","journal-title":"BMC Med Imaging"},{"issue":"1","key":"703_CR22","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2214\/AJR.19.22168","volume":"216","author":"A Ushinsky","year":"2021","unstructured":"Ushinsky A, Bardis M, Glavis-Bloom J, Uchio E, Chantaduly C, Nguyentat M, Chow D, Chang PD, Houshyar R. A 3D\u20132D hybrid U-Net convolutional neural network approach to prostate organ segmentation of multiparametric MRI. AJR Am J Roentgenol. 2021;216(1):111\u20136.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"703_CR23","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1002\/jmri.26337","volume":"49","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Wei R, Gao G, Ding L, Zhang X, Wang X, Zhang J. Fully automatic segmentation on prostate MR images based on cascaded fully convolution network. J Magn Reson Imaging. 2019;49(4):1149\u201356.","journal-title":"J Magn Reson Imaging"},{"issue":"12","key":"703_CR24","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.1002\/mp.14517","volume":"47","author":"Y Chen","year":"2020","unstructured":"Chen Y, Xing L, Yu L, Bagshaw HP, Buyyounouski MK, Han B. Automatic intraprostatic lesion segmentation in multiparametric magnetic resonance images with proposed multiple branch UNet. Med Phys. 2020;47(12):6421\u20139.","journal-title":"Med Phys"},{"issue":"9","key":"703_CR25","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/s41591-018-0107-6","volume":"24","author":"J De Fauw","year":"2018","unstructured":"De Fauw J, Ledsam JR, Romera-Paredes B, Nikolov S, Tomasev N, Blackwell S, Askham H, Glorot X, O\u2019Donoghue B, Visentin D, et al. Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat Med. 2018;24(9):1342\u201350.","journal-title":"Nat Med"},{"issue":"1","key":"703_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13534-020-00179-0","volume":"11","author":"A Comelli","year":"2021","unstructured":"Comelli A, Dahiya N, Stefano A, Benfante V, Gentile G, Agnese V, Raffa GM, Pilato M, Yezzi A, Petrucci G, et al. Deep learning approach for the segmentation of aneurysmal ascending aorta. Biomed Eng Lett. 2021;11(1):15\u201324.","journal-title":"Biomed Eng Lett"},{"issue":"2","key":"703_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/jrr\/rrz086","volume":"61","author":"T Nemoto","year":"2020","unstructured":"Nemoto T, Futakami N, Yagi M, Kumabe A, Takeda A, Kunieda E, Shigematsu N. Efficacy evaluation of 2D, 3D U-Net semantic segmentation and atlas-based segmentation of normal lungs excluding the trachea and main bronchi. J Radiat Res. 2020;61(2):257\u201364.","journal-title":"J Radiat Res"},{"issue":"10","key":"703_CR28","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.2967\/jnumed.117.202317","volume":"59","author":"D Hwang","year":"2018","unstructured":"Hwang D, Kim KY, Kang SK, Seo S, Paeng JC, Lee DS, Lee JS. Improving the accuracy of simultaneously reconstructed activity and attenuation maps using deep learning. J Nucl Med. 2018;59(10):1624\u20139.","journal-title":"J Nucl Med"},{"issue":"2","key":"703_CR29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.cmpb.2009.04.009","volume":"96","author":"R C\u00e1rdenes","year":"2009","unstructured":"C\u00e1rdenes R, de Luis-Garc\u00eda R, Bach-Cuadra M. A multidimensional segmentation evaluation for medical image data. Comput Methods Programs Biomed. 2009;96(2):108\u201324.","journal-title":"Comput Methods Programs Biomed"},{"issue":"1","key":"703_CR30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.bbe.2019.05.002","volume":"40","author":"H Tekchandani","year":"2020","unstructured":"Tekchandani H, Verma S, Londhe ND. Mediastinal lymph node malignancy detection in computed tomography images using fully convolutional network. Biocybern Biomed Eng. 2020;40(1):187\u201399.","journal-title":"Biocybern Biomed Eng"},{"key":"703_CR31","doi-asserted-by":"publisher","first-page":"105478","DOI":"10.1016\/j.cmpb.2020.105478","volume":"194","author":"H Tekchandani","year":"2020","unstructured":"Tekchandani H, Verma S, Londhe N. Performance improvement of mediastinal lymph node severity detection using GAN and Inception network. Comput Methods Programs Biomed. 2020;194:105478.","journal-title":"Comput Methods Programs Biomed"},{"issue":"8","key":"703_CR32","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3390\/jimaging7080131","volume":"7","author":"A Stefano","year":"2021","unstructured":"Stefano A, Comelli A. Customized efficient neural network for COVID-19 infected region identification in CT images. J Imaging. 2021;7(8):131.","journal-title":"J Imaging"},{"issue":"2","key":"703_CR33","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3390\/app11020782","volume":"11","author":"A Comelli","year":"2021","unstructured":"Comelli A, Dahiya N, Stefano A, Vernuccio F, Portoghese M, Cutaia G, Bruno A, Salvaggio G, Yezzi A. Deep learning-based methods for prostate segmentation in magnetic resonance imaging. Appl Sci (Basel). 2021;11(2):782.","journal-title":"Appl Sci (Basel)"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-021-00703-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-021-00703-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-021-00703-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T20:05:32Z","timestamp":1636833932000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-021-00703-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["703"],"URL":"https:\/\/doi.org\/10.1186\/s12880-021-00703-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-956250\/v1","asserted-by":"object"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,13]]},"assertion":[{"value":"5 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the Committee for Medical Ethics, Peking University First Hospital (2021-060). Written informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Jiahao Huang and Xiangpeng Wang are from a medical technical corporation provided technical support for model development. The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"170"}}