{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:44Z","timestamp":1772165684816,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81601546"],"award-info":[{"award-number":["81601546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81520108014"],"award-info":[{"award-number":["81520108014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates the segmental myocardial strain of the early phase of intramyocardial hemorrhage (IMH) caused by reperfused myocardial infarction (MI) in rats by low-dose dobutamine (LDD) cardiovascular magnetic resonance (CMR) feature-tracking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine sham rats and nine rats with 60-min myocardial ischemia followed by 48-h reperfusion were investigated using CMR, including T2*-mapping sequence and fast imaging with steady-state precession (FISP)\u2013cine sequence. Another FISP\u2013cine sequence was acquired after 2\u00a0min of dobutamine injection; the MI, IMH, and Non-MI (NMI) areas were identified. The values of peak radial strains (PRS) and peak circumferential strains (PCS) of the MI, IMH and NMI segments were acquired. The efficiency of PRS and PCS (EPRS and EPCS, respectively) were calculated on the basis of the time of every single heartbeat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PRS, PCS, EPRS, and EPCS of the sham group increased after LDD injection. However, the PRS, PCS, EPRS, and EPCS of the IMH segment did not increase. Moreover, the PRS and PCS of the MI and NMI segments did not increase, but the EPRS and EPCS of these segments increased. The PRS, PCS, EPRS, and EPCS of the IMH segment were lower than those of the MI and NMI segments before and after LDD injection, but without a significant difference between MI segment and NMI segment before and after LDD injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LDD could help assess dysfunctions in segments with IMH, especially using the efficiency of strain. IMH was a crucial factor that decreased segmental movement and reserved function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-021-00709-x","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:02:35Z","timestamp":1637366555000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats"],"prefix":"10.1186","volume":"21","author":[{"given":"Rui","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Bo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Yushu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Jichun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Yongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Fajin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Fabao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"709_CR1","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1007\/s00330-018-5895-z","volume":"29","author":"N Galea","year":"2019","unstructured":"Galea N, Dacquino GM, Ammendola RM, Coco S, Agati L, De Luca L, et al. Microvascular obstruction extent predicts major adverse cardiovascular events in patients with acute myocardial infarction and preserved ejection fraction. Eur Radiol. 2019;29:2369\u201377.","journal-title":"Eur Radiol"},{"key":"709_CR2","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/S0735-1097(00)01186-4","volume":"37","author":"MJ G\u00f6tte","year":"2001","unstructured":"G\u00f6tte MJ, van Rossum AC, Twisk JWR, Kuijer JPA, Marcus JT, Visser CA. Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium. J Am Coll Cardiol. 2001;37:808\u201317.","journal-title":"J Am Coll Cardiol"},{"key":"709_CR3","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1016\/j.jacc.2008.01.064","volume":"51","author":"A Hirsch","year":"2008","unstructured":"Hirsch A, Nijveldt R, Haeck JD, Beek AM, Koch KT, Henriques JP, et al. Relation between the assessment of microvascular injury by cardiovascular magnetic resonance and coronary Doppler flow velocity measurements in patients with acute anterior wall myocardial infarction. J Am Coll Cardiol. 2008;51:2230\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"709_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1532-429X-15-58","volume":"15","author":"A Kidambi","year":"2013","unstructured":"Kidambi A, Mather AN, Motwani M, Swoboda P, Uddin A, Greenwood JP, et al. The effect of microvascular obstruction and intramyocardial hemorrhage on contractile recovery in reperfused myocardial infarction: insights from cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2013;15:58.","journal-title":"J Cardiovasc Magn Reson"},{"key":"709_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.echo.2013.09.011","volume":"27","author":"C Bergerot","year":"2014","unstructured":"Bergerot C, Mewton N, Lacote-Roiron C, Ernande L, Ovize M, Croisille P, et al. Influence of microvascular obstruction on regional myocardial deformation in the acute phase of myocardial infarction: a speckle-tracking echocardiography study. J Am Soc Echocardiogr. 2014;27:93\u2013100.","journal-title":"J Am Soc Echocardiogr"},{"key":"709_CR6","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1161\/01.CIR.90.3.1502","volume":"90","author":"J Sklenar","year":"1994","unstructured":"Sklenar J, Ismail S, Villanueva FS, Goodman NC, Glasheen WP, Kaul S. Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion. An experimental evaluation. Circulation. 1994;90:1502\u201312.","journal-title":"Circulation"},{"key":"709_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12968-014-0083-z","volume":"16","author":"S Glaveckaite","year":"2014","unstructured":"Glaveckaite S, Valeviciene N, Palionis D, Puronaite R, Serpytis P, Laucevicius A. Prediction of long-term segmental and global functional recovery of hibernating myocardium after revascularisation based on low dose dobutamine and late gadolinium enhancement cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2014;16:83.","journal-title":"J Cardiovasc Magn Reson"},{"key":"709_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12880-017-0223-7","volume":"17","author":"T Lapinskas","year":"2017","unstructured":"Lapinskas T, Grune J, Zamani SM, Jeuthe S, Messroghli D, Gebker R, et al. Cardiovascular magnetic resonance feature tracking in small animals - a preliminary study on reproducibility and sample size calculation. BMC Med Imaging. 2017;17:51.","journal-title":"BMC Med Imaging"},{"key":"709_CR9","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1177\/0284185114547899","volume":"56","author":"R Xia","year":"2015","unstructured":"Xia R, Lu X, Zhang B, Wang Y, Liao J, Zheng J, et al. Assessment of myocardial edema and area at risk in a rat model of myocardial infarction with a faster T2 mapping method. Acta Radiol. 2015;56:1085\u201390.","journal-title":"Acta Radiol"},{"key":"709_CR10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/jmri.25145","volume":"44","author":"W Chen","year":"2016","unstructured":"Chen W, Zhang B, Xia R, Zhang R, Xu Z, Chen Y, et al. T2 mapping at 7T MRI can quantitatively assess intramyocardial hemorrhage in rats with acute reperfused myocardial infarction in vivo. J Magn Reson Imaging. 2016;44:194\u2013203.","journal-title":"J Magn Reson Imaging"},{"key":"709_CR11","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1148\/radiol.12121516","volume":"267","author":"A Kidambi","year":"2013","unstructured":"Kidambi A, Mather AN, Swoboda P, Motwani M, Fairbairn TA, Greenwood JP, et al. Relationship between myocardial edema and regional myocardial function after reperfused acute myocardial infarction: an MR imaging study. Radiology. 2013;267:701\u20138.","journal-title":"Radiology"},{"key":"709_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1532-429X-10-48","volume":"10","author":"JL Daire","year":"2008","unstructured":"Daire JL, Jacob JP, Hyacinthe JN, Croisille P, Montet-Abou K, Richter S, et al. Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study. J Cardiovasc Magn Reson. 2008;10:48.","journal-title":"J Cardiovasc Magn Reson"},{"key":"709_CR13","doi-asserted-by":"publisher","first-page":"I33","DOI":"10.1161\/CIRCULATIONAHA.105.000885","volume":"114","author":"D Bree","year":"2006","unstructured":"Bree D, Wollmuth JR, Cupps BP, Krock MD, Howells A, Rogers J, et al. Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy. Circulation. 2006;114:I33\u20136.","journal-title":"Circulation"},{"key":"709_CR14","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11897-009-0021-9","volume":"6","author":"N Bettencourt","year":"2009","unstructured":"Bettencourt N, Chiribiri A, Schuster A, Nagel E. Assessment of myocardial ischemia and viability using cardiac magnetic resonance. Curr Heart Fail Rep. 2009;6:142\u201353.","journal-title":"Curr Heart Fail Rep"},{"key":"709_CR15","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.echo.2016.06.011","volume":"29","author":"H Zhao","year":"2016","unstructured":"Zhao H, Lee AP, Li Z, Qiao Z, Fan Y, An D, et al. Impact of intramyocardial hemorrhage and microvascular obstruction on cardiac mechanics in reperfusion injury: a speckle-tracking echocardiographic study. J Am Soc Echocardiogr. 2016;29:973\u201382.","journal-title":"J Am Soc Echocardiogr"},{"key":"709_CR16","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1161\/01.CIR.99.6.763","volume":"99","author":"E Nagel","year":"1999","unstructured":"Nagel E, Lehmkuhl HB, Bocksch W, Klein C, Vogel U, Frantz E, et al. Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation. 1999;99:763\u201370.","journal-title":"Circulation"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-021-00709-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-021-00709-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-021-00709-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:02:37Z","timestamp":1637366557000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-021-00709-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,20]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["709"],"URL":"https:\/\/doi.org\/10.1186\/s12880-021-00709-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-506296\/v1","asserted-by":"object"}]},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,20]]},"assertion":[{"value":"8 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving animals were in accordance with Guiding Principles for the Care and Use of Animals and was approved by the Animal Ethics Committee of West China Hospital, Sichuan University (Chengdu 610041) and the laboratory animal production license was 2021381A. And this study was carried out in compliance with the Animal Research: Reporting in Vivo Experiments (ARRIVE) guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}