{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:45:47Z","timestamp":1791852347878,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The pathology, treatment and prognosis of malignant non-Wilms tumors (NWTs) are different, so it is necessary to differentiate these types of tumors. The purpose of this study was to review the clinical and imaging features of malignant NWTs and features of tumor metastasis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively analyzed the CT images of 65 pediatric patients with NWTs from March 2008 to July 2020, mainly including clear cell sarcoma of the kidney (CCSK), malignant rhabdomyoma tumor of the kidney (MRTK) and renal cell carcinoma (RCC). Available pretreatment contrast-enhanced abdominal CT examinations were reviewed. The clinical features of the patients, imaging findings of the primary mass, and locoregional metastasis patterns were evaluated in correlation with pathological and surgical findings.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study included CCSK (22 cases), MRTK (27 cases) and RCC (16 cases). There were no significant differences observed among the sex ratios of CCSK, MRTK and RCC (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Among the three tumors, the onset age of MRTK patients was the smallest, while that of RCC patients was the largest (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The tumor diameter of CCSK was larger than that of MRTK and RCC (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). For hemorrhage and necrosis, the proportion of MRTK patients was larger than that of the other two tumors (<jats:italic>P<\/jats:italic>\u2009=\u20090.017). For calcification in tumors, the proportion of calcification in RCC was highest (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). Only MRTK showed subcapsular fluid (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the arterial phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), and the proportion of marked enhancement was the highest (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). In the venous phase, the proportion of slight enhancement in RCC was lower than that in the other two tumors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Only CCSK had bone metastasis. There was no liver and lung metastasis in RCC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>NWTs have their own imaging and clinical manifestations. CCSK can cause vertebral metastasis, MRTK can cause subcapsular effusion, and RCC tumor density is usually high and calcification. These diagnostic points can play a role in clinical diagnosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-021-00715-z","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T02:03:18Z","timestamp":1638324198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Imaging features and differences among the three primary malignant non-Wilms tumors in children"],"prefix":"10.1186","volume":"21","author":[{"given":"Yupeng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"issue":"4","key":"715_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.rcl.2011.05.003","volume":"49","author":"E Geller","year":"2011","unstructured":"Geller E, Kochan PS. 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All methods were carried out in accordance with relevant guidelines and regulations. This study was a retrospective case\u2013control investigation approved by the Ethics Committee of hospital, and the requirement for the consent of patients was waived.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"181"}}