{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:36:28Z","timestamp":1776108988604,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Follow-up imaging in intracerebral hemorrhage is not standardized and radiologists rely on different imaging modalities to determine hematoma growth. This study assesses the volumetric accuracy of different imaging modalities (MRI, CT angiography, postcontrast CT) to measure hematoma size.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>28 patients with acute spontaneous intracerebral hemorrhage referred to a tertiary stroke center were retrospectively included between 2018 and 2019. Inclusion criteria were (1) spontaneous intracerebral hemorrhage (supra- or infratentorial), (2) noncontrast CT imaging performed on admission, (3) follow-up imaging (CT angiography, postcontrast CT, MRI), and (4) absence of hematoma expansion confirmed by a third cranial image within 6\u00a0days. Two independent raters manually measured hematoma volume by drawing a region of interest on axial slices of admission noncontrast CT scans as well as on follow-up imaging (CT angiography, postcontrast CT, MRI) using a semi-automated segmentation tool (Visage image viewer; version 7.1.10). Results were compared using Bland\u2013Altman plots.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean admission hematoma volume was 18.79\u2009\u00b1\u200919.86\u00a0cc. All interrater and intrarater intraclass correlation coefficients were excellent (1; IQR 0.98\u20131.00). In comparison to hematoma volume on admission noncontrast CT volumetric measurements were most accurate in patients who received postcontrast CT (bias of \u2212\u20092.47%, SD 4.67: n\u2009=\u200910), while CT angiography often underestimated hemorrhage volumes (bias of 31.91%, SD 45.54; n\u2009=\u200920). In MRI sequences intracerebral hemorrhage volumes were overestimated in T2* (bias of \u2212\u200964.37%, SD 21.65; n\u2009=\u200910). FLAIR (bias of 6.05%, SD 35.45; n\u2009=\u200913) and DWI (bias of-14.6%, SD 31.93; n\u2009=\u200912) over- and underestimated hemorrhagic volumes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Volumetric measurements were most accurate in postcontrast CT while CT angiography and MRI sequences often substantially over- or underestimated hemorrhage volumes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00735-3","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T12:02:43Z","timestamp":1642248163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Volumetric accuracy of different imaging modalities in acute intracerebral hemorrhage"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-0627","authenticated-orcid":false,"given":"Frieder","family":"Schlunk","sequence":"first","affiliation":[]},{"given":"Johannes","family":"Kuthe","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Harmel","sequence":"additional","affiliation":[]},{"given":"Heinrich","family":"Audebert","sequence":"additional","affiliation":[]},{"given":"Uta","family":"Hanning","sequence":"additional","affiliation":[]},{"given":"Georg","family":"Bohner","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Scheel","sequence":"additional","affiliation":[]},{"given":"Justus","family":"Kleine","sequence":"additional","affiliation":[]},{"given":"Jawed","family":"Nawabi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"735_CR1","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.emc.2016.06.010","volume":"34","author":"A Morotti","year":"2016","unstructured":"Morotti A, Goldstein JN. Diagnosis and management of acute intracerebral hemorrhage. Emerg Med Clin N Am. 2016;34:883\u201399.","journal-title":"Emerg Med Clin N Am"},{"key":"735_CR2","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1161\/STR.0000000000000069","volume":"46","author":"JC Hemphill 3rd","year":"2015","unstructured":"Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2015;46:2032\u201360.","journal-title":"Stroke"},{"key":"735_CR3","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1161\/STROKEAHA.113.003701","volume":"45","author":"F Macellari","year":"2014","unstructured":"Macellari F, Paciaroni M, Agnelli G, Caso V. Neuroimaging in intracerebral hemorrhage. 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Informed consent of individual patients was waived for this retrospective study with anonymized data according to pertinent institutional guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Heinrich Audebert reports funding from the German Research Foundation (DFG), the federal Ministry of Education and Research (BMBF), Berlin Innovation Funds, Pfizer and German Stroke Foundation. He reports speaker fees and consultancy honoraria during the conduct of the study from Bayer Vital, Boehringer Ingelheim Pharma, Bristol-Myers Squibb, Novo Nordisk, Pfizer, and Takeda.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9"}}