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The participants underwent 3.0\u00a0T conventional MRI plus a multi-echo sequence. The cartilage of each participant was divided into twenty eight subregions. We then calculated the T2 mean values and standard deviation or median and quartile range for each subregion according to whether the normal distribution was satisfied. Besides, we employed Kruskal\u2013Wallis test to determine the statistical differences of each subregion in the control group while the Mann\u2013Whitney U test was used to define the statistical difference between the case group and the control group and between the control group and subjects aged less than or equal to 35\u00a0years in the case group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the case group, age of 30 male patients was 31.5\u2009\u00b1\u20099.3 and age of 36 female patients was 35.7\u2009\u00b1\u20098.3. In the two groups, the superficial central lateral femoral region exhibited relatively high T2 values (control\/case group: 49.6\u2009\u00b1\u20092.7\/55.9\u2009\u00b1\u20098.8), and the deep medial patellar region exhibited relatively low T2 values (control\/case group: 34.2\u2009\u00b1\u20091.3\/33.5(32.2, 35.5)). Comparison of the T2 values between the case and the control group demonstrated a statistically significant increase in nine subregions (P<jats:sub>1<\/jats:sub>\u2009&lt;\u20090.05) and there were five subregions in the case group with age \u2264\u200935\u00a0years (P<jats:sub>2<\/jats:sub>\u2009&lt;\u20090.05). In particular, the <jats:italic>p<\/jats:italic>-values for four subregions of the patellofemoral joint were all less than 0.05 (P<jats:sub>1<\/jats:sub>\u2009=\u20090.002, 0.015, 0.036, 0.005).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>T2 values of patients were significantly different with values of healthy groups, especially in the superficial cartilage of the patellofemoral joint. It made T2 mapping helpful to early identify patients with knee cartilage degeneration.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00799-1","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T16:04:48Z","timestamp":1650297888000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["T2 mapping for knee cartilage degeneration in young patients with mild symptoms"],"prefix":"10.1186","volume":"22","author":[{"given":"Huiyu","family":"Zhao","sequence":"first","affiliation":[]},{"given":"Hongqiu","family":"Li","sequence":"additional","affiliation":[]},{"given":"Shuo","family":"Liang","sequence":"additional","affiliation":[]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"issue":"9783","key":"799_CR1","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","volume":"377","author":"JW Bijlsma","year":"2011","unstructured":"Bijlsma JW, Berenbaum F, Lafeber FP. 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Informed consent is taken from all the participants present in the study. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The consent for publication have been obtained from participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}