{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T08:42:29Z","timestamp":1652344949911},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["NSFC 81101092"],"award-info":[{"award-number":["NSFC 81101092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acoustic structure quantification (ASQ) has been applied to evaluate liver histologic changes by analyzing the speckle pattern seen on B-mode ultrasound. We aimed to assess the severity of portal hypertension (PHT) through hepatic ultrasonography.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Sixty patients diagnosed with PHT and underwent surgical treatment with portosystemic shunts were enrolled. Portal pressure (PP) was measured intraoperatively. Patients were divided into subgroups according to the severity of gastroesophageal varices and Child\u2013Pugh class. Three difference ratio (C<jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup>) values on ASQ histogram mode were analyzed for their relationships with PP, degree of gastroesophageal varices and Child\u2013Pugh liver function. Thirty healthy volunteers matched with the patients for gender and age were enrolled as controls. Comparisons among groups and correlation of the parameters with PP were analyzed. Area under the receive operating characteristic curve was used to evaluate the predicting value of ASQ parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the patients, the ASQ parameters peak <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup> (<jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>max<\/jats:sub>), mean <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup> (<jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>mean<\/jats:sub>) and the highest occurred <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup> value of the obtained red curve (<jats:italic>R<\/jats:italic><jats:sub>max<\/jats:sub><jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup>) were all greatly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic>\u2009=\u20090.027). Multiple comparisons indicated that, regardless of Child\u2013Pugh class and degree of gastroesophageal varices, the patients had significantly increased <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>max<\/jats:sub> and <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>mean<\/jats:sub> compared with the controls (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). No differences among subgroups were observed. <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>max<\/jats:sub> was significantly statistically correlated with PP (<jats:italic>r<\/jats:italic>\u2009=\u20090.3505, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), degree of varices (<jats:italic>r<\/jats:italic>\u2009=\u20090.4998, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Youden\u2019s index for <jats:italic>C<\/jats:italic><jats:sub>m<\/jats:sub><jats:sup>2<\/jats:sup><jats:sub>max<\/jats:sub> with a cut-off value of 140.3 for predicting the presence of PHT, gastroesophageal varices and liver function equal to or worse than Child\u2013Pugh class B were 0.8, 0.91 and 0.84, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>ASQ analysis of ultrasonographic images may have a role in the evaluation of the severity of PHT by detecting liver histologic changes in the speckle pattern caused by cirrhosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00817-2","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T08:09:58Z","timestamp":1652342998000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The severity of portal hypertension by a non-invasive assessment: acoustic structure quantification analysis of liver parenchyma"],"prefix":"10.1186","volume":"22","author":[{"given":"Wen-Bin","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Kai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-You","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"issue":"40","key":"817_CR1","doi-asserted-by":"publisher","first-page":"6111","DOI":"10.3748\/wjg.v26.i40.6111","volume":"26","author":"LS Gunarathne","year":"2020","unstructured":"Gunarathne LS, Rajapaksha H, Shackel N, Angus PW, Herath CB. 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All the methods were performed in accordance with the relevant guidelines and regulations of the institutional and national research committee. Informed consent was obtained from all individual participants included in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"85"}}