{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:24:21Z","timestamp":1771273461411,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This study aimed to analyze the application value of magnetic resonance (MR)-perfusion weighted imaging (PWI) in the early imaging diagnosis of rabbit spinal tuberculosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Spinal tuberculosis model was established using ATCC25177 <jats:italic>Mycobacterium tuberculosis<\/jats:italic> strain in the lumbar spine of rabbits. Forty rabbits were divided into 2 groups: rabbits in the experiment group were injected with 0.2\u00a0ml of 5.0\u00a0mg\/ml tuberculosis suspension (n\u2009=\u200930) and those in the control group were injected with 0.2\u00a0ml of normal saline (n\u2009=\u200910) after vertebrae drilling surgery. Routine MRI and MR-PWI were performed at 4, 6, and 8\u00a0weeks after surgery. The statistical difference in terms of perfusion parameter values in the early MR-PWI scan of spinal tuberculosis between two groups was analyzed. The receiver operating characteristic (ROC) curve analysis was conducted for the accuracy of MR-PWI parameters in the early diagnosis of spinal tuberculosis.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Except time to peak, the other perfusion parameters in the experiment group were all increased with time. In addition, the difference between the two groups, as well as the differences at each time point was statistically significant (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). First-pass enhancement rate (Efirst), early enhancement rate (Ee), peak height (PH), maximum slope of increase (MSI), maximum signal enhancement rate (Emax) and signal enhancement rate (SER) showed high values in early diagnosing spinal tuberculosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The parameters including Efirst, Ee, PH, MSI, Emax and SER may provide valuable imaging evidence for the early diagnosis of spinal tuberculosis in clinical application.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00870-x","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T11:03:34Z","timestamp":1660043014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early diagnosis of spinal tuberculosis by magnetic resonance: perfusion weighted imaging in a rabbit model"],"prefix":"10.1186","volume":"22","author":[{"given":"Xiaochen","family":"Liu","sequence":"first","affiliation":[]},{"given":"Yunlin","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Wenxiao","family":"Jia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"issue":"4","key":"870_CR1","doi-asserted-by":"publisher","first-page":"618","DOI":"10.4184\/asj.2017.11.4.618","volume":"11","author":"S Singh","year":"2017","unstructured":"Singh S, Dawar H, Das K, Mohapatra B, Prasad S. 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