{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:53:25Z","timestamp":1777791205253,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and purpose<\/jats:title>\n                <jats:p>Synthetic MR imaging (SyMRI) allows the reconstruction of various contrast images, including double inversion recovery (DIR), from a single scan. This study aimed to investigate the advantages of SyMRI by comparing synthetic DIR images with synthetic T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) and conventional DIR images.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We retrospectively reviewed the imaging data of 100 consecutive patients who underwent brain MRI between December 2018 and March 2019. Synthetic DIR, T2W-FLAIR, T1-weighted, and phase-sensitive inversion recovery (PSIR) images were generated from SyMRI data. For synthetic DIR, the two inversion times required to suppress white matter and cerebrospinal fluid (CSF) were manually determined by two radiologists. Quantitative analysis was performed by manually tracing the region of interest (ROI) at the sites of the lesion, white matter, and CSF. Synthetic DIR, synthetic T2W-FLAIR, and conventional DIR images were compared on the basis of using the gray matter-to-white matter, lesion-to-white matter, and lesion-to-CSF contrast-to-noise ratios.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The two radiologists showed no differences in setting inversion time (TI) values, and their evaluations showed excellent interobserver agreement. The mean signal intensities obtained with synthetic DIR were significantly higher than those obtained with synthetic T2W-FLAIR and conventional DIR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Synthetic DIR images showed a higher contrast than synthetic T2WFLAIR and conventional DIR images.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00877-4","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T14:04:53Z","timestamp":1666879493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthetic double inversion recovery imaging in brain MRI: quantitative evaluation and feasibility of synthetic MRI and a comparison with conventional double inversion recovery and fluid-attenuated inversion recovery sequences"],"prefix":"10.1186","volume":"22","author":[{"given":"Odgerel","family":"Zorigt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kumasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Jingu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"issue":"3","key":"877_CR1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/BF01705296","volume":"2","author":"TW Redpath","year":"1994","unstructured":"Redpath TW, Smith FW. Imaging gray brain matter with a double-inversion pulse sequence to suppress CSF and white matter signals. Magn Reson Mater Phys, Biol Med. 1994;2(3):451\u20135.","journal-title":"Magn Reson Mater Phys, Biol Med"},{"issue":"1","key":"877_CR2","first-page":"54","volume":"28","author":"MP Wattjes","year":"2007","unstructured":"Wattjes MP, Lutterbey GG, Gieseke J, Traber F, Klotz L, Schmidt S, Schild HH. Double inversion\u00a8 recovery brain imaging at 3T: diagnostic value in the detection of multiple sclerosis lesions. Am J Neuroradiol. 2007;28(1):54\u20139.","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"877_CR3","doi-asserted-by":"publisher","first-page":"210","DOI":"10.13104\/imri.2019.23.3.210","volume":"23","author":"NY Choi","year":"2019","unstructured":"Choi NY, Park S, Lee CM, Ryu C-W, Jahng G-H. The role of double inversion recovery imaging in acute ischemic stroke. 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J Neuroradiol. 2018;46(2):107\u201316. https:\/\/doi.org\/10.1016\/j.neurad.2018.06.002.","journal-title":"J Neuroradiol"},{"issue":"4","key":"877_CR6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s11682-015-9469-2","volume":"10","author":"G-H Jahng","year":"2016","unstructured":"Jahng G-H, Lee DK, Lee J-M, Rhee HY, Ryu C-W. Double inversion recovery imaging improves the evaluation of gray matter volume losses in patients with Alzheimer\u2019s disease and mild cognitive impairment. Brain Imaging Behav. 2016;10(4):1015\u201328. https:\/\/doi.org\/10.1007\/s11682-015-9469-2.","journal-title":"Brain Imaging Behav"},{"issue":"6","key":"877_CR7","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.3174\/ajnr.A5227","volume":"38","author":"LN Tanenbaum","year":"2017","unstructured":"Tanenbaum LN, Tsiouris AJ, Johnson AN, Naidich TP, DeLano MC, Melhem ER, Quarterman P, Parameswaran SX, Shankaranarayanan A, Goyen M, Field AS. 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Investig Radiol. 2017;52(10):647\u201357. https:\/\/doi.org\/10.1097\/RLI.0000000000000365.","journal-title":"Investig Radiol"},{"issue":"2","key":"877_CR9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3174\/ajnr.a5012","volume":"38","author":"A Hagiwara","year":"2017","unstructured":"Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Tabata T, Kamagata K, Suzuki M, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Hamasaki N, Kunimatsu A, Aoki S. Synthetic MRI in the detection of multiple sclerosis plaques. Am J Neuroradiol. 2017;38(2):257\u201363. https:\/\/doi.org\/10.3174\/ajnr.a5012.","journal-title":"Am J Neuroradiol"},{"issue":"4","key":"877_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2463\/mrms.ci.2015-0164","volume":"15","author":"C Andica","year":"2016","unstructured":"Andica C, Hagiwara A, Nakazawa M, Tsuruta K, Takano N, Hori M, Suzuki H, Sugano H, Arai H, Aoki S. 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Am J Neuroradiol. 2016;37(6):1023\u20139. https:\/\/doi.org\/10.3174\/ajnr.A4665.","journal-title":"Am J Neuroradiol"},{"issue":"1036","key":"877_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/postgradmedj-2011-130307","volume":"88","author":"BE Grueter","year":"2012","unstructured":"Grueter BE, Schulz UG. Age-related cerebral white matter disease (leukoaraiosis): a review. Postgrad Med J. 2012;88(1036):79. https:\/\/doi.org\/10.1136\/postgradmedj-2011-130307.","journal-title":"Postgrad Med J"},{"issue":"9","key":"877_CR15","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1177\/0271678x211002279","volume":"41","author":"P Huang","year":"2021","unstructured":"Huang P, Zhang R, Jiaerken Y, Wang S, Yu W, Hong H, Lian C, Li K, Zeng Q, Luo X, Yu X, Xu X, Wu X, Zhang M. Deep white matter hyperintensity is associated with the dilation of perivascular space. 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Stroke. 2018;45(2):605\u20137. https:\/\/doi.org\/10.1161\/strokeaha.113.004059.","journal-title":"Stroke"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-022-00877-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-022-00877-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-022-00877-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T14:10:51Z","timestamp":1666879851000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-022-00877-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["877"],"URL":"https:\/\/doi.org\/10.1186\/s12880-022-00877-4","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"26 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Committee of the Fujioka General Hospital approved the study as well as the informed consent waiver (FJ-152). The authors confirmed that all methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"183"}}