{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:57:37Z","timestamp":1772693857609,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Jiangsu Provincial Special Program of Medical Science","award":["BE2021604 to Xiao-Quan Xu"],"award-info":[{"award-number":["BE2021604 to Xiao-Quan Xu"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81971613 to Hai-Bin Shi"],"award-info":[{"award-number":["81971613 to Hai-Bin Shi"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Our study aimed to compare the time consumption and success rate between CTA- and CTP- based assessment strategy, and to clarify the risk factors associated with the CTP scan failure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Clinical and radiological data of 437 consecutive AIS patients who underwent multiphase CTA or CTP for pre-treatment evaluation were retrospectively enrolled (CTA group, n\u2009=\u2009302; CTP group, n\u2009=\u2009135). Time consumption and success rate of CTA- and CTP- based assessment strategy were compared using Mann\u2013Whitney U test and Chi-Squared Test. Univariate analysis and receiver operating curve analysis were used to clarify the risk factors, and their performance in predicting the CTP scan failure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Time consumption of CTP scan and reconstruction was significantly longer than that of CTA [775\u00a0s vs 263.5\u00a0s, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]. CTP scan showed significantly higher failure rate than CTA (11% vs 1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Severe motion was the most common cause of CTP failure (n\u2009=\u200912, 80%). Baseline National Institute of Health Stroke Scale (NIHSS) score in CTP failure group was significantly higher than that in CTP success group [17 vs 13, <jats:italic>P<\/jats:italic>\u2009=\u20090.007]. Baseline NIHSS score of 11 was the optimal threshold value to predict CTP failure with an area under the curve of 0.715, a sensitivity of 86.7%, and a specificity of 45.0%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CTP- based strategy showed longer time consumption and higher failure rate than CTA- based strategy. High baseline NIHSS score was significantly associated with CTP scan failure in AIS patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00880-9","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T08:03:18Z","timestamp":1661846598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of time consumption and success rate between CT angiography- and CT perfusion- based imaging assessment strategy for the patients with acute ischemic stroke"],"prefix":"10.1186","volume":"22","author":[{"given":"Yue","family":"Chu","sequence":"first","affiliation":[]},{"given":"Gao","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Xiao-Quan","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Shan-Shan","family":"Lu","sequence":"additional","affiliation":[]},{"given":"Hai-Bin","family":"Shi","sequence":"additional","affiliation":[]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Qiang-Hui","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Fei-Yun","family":"Wu","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"issue":"390","key":"880_CR1","first-page":"1151","volume":"2017","author":"GBD","year":"2016","unstructured":"GBD. Causes of death collaborators: global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2016;2017(390):1151\u2013210.","journal-title":"Lancet"},{"key":"880_CR2","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1161\/STROKEAHA.119.027708","volume":"50","author":"JJ Warner","year":"2019","unstructured":"Warner JJ, Harrington RA, Sacco RL, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke. Stroke. 2019;50:3331\u20132.","journal-title":"Stroke"},{"key":"880_CR3","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1136\/jnnp.2004.059261","volume":"76","author":"PA Barber","year":"2005","unstructured":"Barber PA, Hill MD, Eliasziw M, et al. Aspects study group. imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion weighted imaging. J Neurol Neurosurg Psychiatr. 2005;76:1528\u201333.","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"880_CR4","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00062-018-0717-x","volume":"29","author":"M Reid","year":"2019","unstructured":"Reid M, Famuyide AO, Forkert ND, et al. Accuracy and reliability of multiphase CTA perfusion for identifying ischemic core. Clin Neuroradiol. 2019;29:543\u201352.","journal-title":"Clin Neuroradiol"},{"key":"880_CR5","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1148\/radiol.15142256","volume":"275","author":"BK Menon","year":"2015","unstructured":"Menon BK, d\u2019Esterre CD, Qazi EM, et al. Multiphase CT angiography: a new tool for the imaging triage of patients with acute ischemic stroke. Radiology. 2015;275:510\u201320.","journal-title":"Radiology"},{"key":"880_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11\u201321.","journal-title":"N Engl J Med"},{"key":"880_CR7","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","volume":"378","author":"GW Albers","year":"2018","unstructured":"Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708\u201318.","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"880_CR8","doi-asserted-by":"publisher","first-page":"i62","DOI":"10.1136\/neurintsurg-2012-010512","volume":"5","author":"KN Sheth","year":"2013","unstructured":"Sheth KN, Terry JB, Nogueira RG, et al. Advanced modality imaging evaluation in acute ischemic stroke may lead to delayed endovascular reperfusion therapy without improvement in clinical outcomes. J Neurointerv Surg. 2013;5(Suppl 1):i62-65.","journal-title":"J Neurointerv Surg"},{"key":"880_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/RCT.0000000000000946","volume":"44","author":"F Kauw","year":"2020","unstructured":"Kauw F, Heit JJ, Martin BW, et al. Computed tomography perfusion data for acute ischemic stroke evaluation using rapid software: pitfalls of automated postprocessing. J Comput Assist Tomogr. 2020;44:75\u20137.","journal-title":"J Comput Assist Tomogr"},{"key":"880_CR10","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1161\/STROKEAHA.120.031929","volume":"52","author":"JM Olivot","year":"2021","unstructured":"Olivot JM, Albucher JF, Guenego A, et al. Mismatch profile influences outcome after mechanical thrombectomy. Stroke. 2021;52:232\u201340.","journal-title":"Stroke"},{"key":"880_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1161\/STROKEAHA.111.630954","volume":"43","author":"AM Fr\u00f6lich","year":"2012","unstructured":"Fr\u00f6lich AM, Psychogios MN, Klotz E, et al. Angiographic reconstructions from whole-brain perfusion CT for the detection of large vessel occlusion in acute stroke. Stroke. 2012;43:97\u2013102.","journal-title":"Stroke"},{"key":"880_CR12","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","volume":"372","author":"BC Campbell","year":"2015","unstructured":"Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009\u201318.","journal-title":"N Engl J Med"},{"key":"880_CR13","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.1007\/s00330-019-06027-9","volume":"29","author":"SS Lu","year":"2019","unstructured":"Lu SS, Zhang X, Xu XQ, et al. Comparison of CT angiography collaterals for predicting target perfusion profile and clinical outcome in patients with acute ischemic stroke. Eur Radiol. 2019;29:4922\u20139.","journal-title":"Eur Radiol"},{"key":"880_CR14","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s10072-021-05387-9","volume":"43","author":"G Ma","year":"2022","unstructured":"Ma G, Cao YZ, Xu XQ, et al. Incremental value of Alberta stroke program early CT Score to collateral score for predicting target mismatch in stroke patients with extended time window or unknown onset time. Neurol Sci. 2022;43:1097\u2013104.","journal-title":"Neurol Sci"},{"key":"880_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11\u201321.","journal-title":"N Engl J Med"},{"key":"880_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.041","volume":"28","author":"J Vanicek","year":"2019","unstructured":"Vanicek J, Cimflova P, Bulik M, et al. Single-centre experience with patients selection for mechanical thrombectomy based on automated computed tomography perfusion analysis: a comparison with computed tomography CT perfusion thrombectomy trials. J Stroke Cerebrovasc Dis. 2019;28:1085\u201392.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"880_CR17","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3174\/ajnr.A6959","volume":"42","author":"S Nannoni","year":"2021","unstructured":"Nannoni S, Ricciardi F, Strambo D, et al. Correlation between ASPECTS and core volume on CT perfusion: Impact of time since stroke onset and presence of large-vessel occlusion. Am J Neuroradiol. 2021;42:422\u20138.","journal-title":"Am J Neuroradiol"}],"container-title":["BMC Medical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-022-00880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12880-022-00880-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12880-022-00880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T08:03:38Z","timestamp":1661846618000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedimaging.biomedcentral.com\/articles\/10.1186\/s12880-022-00880-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["880"],"URL":"https:\/\/doi.org\/10.1186\/s12880-022-00880-9","relation":{},"ISSN":["1471-2342"],"issn-type":[{"value":"1471-2342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the First Hospital of Nanjing Medical University\u2019s ethical committee for studies in humans. All methods were carried out in accordance with relevant guidelines and regulations. The requirement for a written informed consent was waived due to the retrospective nature of the study and the First Hospital of Nanjing Medical University\u2019s ethical committee granted exemption from requiring informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"152"}}