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All patients received prior transthoracic echocardiography (TTE) with AR severity grading according to a recommended multiparametric approach.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After assigning 2DPC measurements into AR grading, agreement between TTE AR grading and 2DPC was good (<jats:italic>\u03ba<\/jats:italic>\u2009=\u20090.88). In 4D flow, antegrade flow was similar between the six levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.87). Net flow was higher at level 1\u20132 than at levels 3\u20136 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Retrograde flow and regurgitant fraction at level 1\u20132 were lower compared to levels 3\u20136 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Reproducibility (inter-reader agreement: ICC 0.993, 95% CI 0.986\u20130.99; intra-reader agreement: ICC 0.982, 95%CI 0.943\u20130.994) as well as measurement agreement between 4D flow and 2DPC (ICC 0.994; 95%CI 0.989 \u2013 0.998) was best at the level of PA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>For estimating severity of AR in 4D flow, best reproducibility along with best agreement with 2DPC measurements can be expected at the level of PA. Measurements at AV or below AV might underestimate AR.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00895-2","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T07:05:14Z","timestamp":1664262314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative evaluation of aortic valve regurgitation in 4D flow cardiac magnetic resonance: at which level should we measure?"],"prefix":"10.1186","volume":"22","author":[{"given":"Malgorzata","family":"Polacin","sequence":"first","affiliation":[]},{"given":"Julia","family":"Geiger","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Burkhardt","sequence":"additional","affiliation":[]},{"given":"Fraser M.","family":"Callaghan","sequence":"additional","affiliation":[]},{"given":"Emanuela","family":"Valsangiacomo","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Kellenberger","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"895_CR1","doi-asserted-by":"publisher","unstructured":"Bonow RO, Carabello BA, Chatterjee K, De Leon AC, Faxon DP, Freed MD, et al. 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Informed consent was obtained from all individual participants (or their parent or legal guardian in the case of children under 16 or illiterate participants) included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors affirm that participants (or their parent or legal guardian in the case of children under 16 or illiterate participants) provided written consent for publication, also for publishing images (Fig.\u00a0).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"169"}}