{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:48:02Z","timestamp":1775022482070,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Beijing Scholar","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"National Key Research and Development Program of China","award":["2019YFE0107800"],"award-info":[{"award-number":["2019YFE0107800"]}]},{"name":"Beijing Municipal Commission of Science and Technology","award":["Z201100005620009"],"award-info":[{"award-number":["Z201100005620009"]}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support","award":["ZYLX202101"],"award-info":[{"award-number":["ZYLX202101"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The aim of this study was to investigate the ability of a pixel-to-pixel generative adversarial network (GAN) to remove motion artefacts in coronary CT angiography (CCTA) images.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ninety-seven patients who underwent single-cardiac-cycle multiphase CCTA were retrospectively included in the study, and raw CCTA images and SnapShot Freeze (SSF) CCTA images were acquired. The right coronary artery (RCA) was investigated because its motion artefacts are the most prominent among the artefacts of all coronary arteries. The acquired data were divided into a training dataset of 40 patients, a verification dataset of 30 patients and a test dataset of 27 patients. A pixel-to-pixel GAN was trained to generate improved CCTA images from the raw CCTA imaging data using SSF CCTA images as targets. The GAN\u2019s ability to remove motion artefacts was evaluated by the structural similarity (SSIM), Dice similarity coefficient (DSC) and circularity index. Furthermore, the image quality was visually assessed by two radiologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The circularity was significantly higher for the GAN-generated images than for the raw images of the RCA (0.82\u2009\u00b1\u20090.07 vs. 0.74\u2009\u00b1\u20090.11, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and there was no significant difference between the GAN-generated images and SSF images (0.82\u2009\u00b1\u20090.07 vs. 0.82\u2009\u00b1\u20090.06, <jats:italic>p<\/jats:italic>\u2009=\u20090.96). Furthermore, the GAN-generated images achieved the SSIM of 0.87\u2009\u00b1\u20090.06, significantly better than those of the raw images 0.83\u2009\u00b1\u20090.08 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The results for the DSC showed that the overlap between the GAN-generated and SSF images was significantly higher than the overlap between the GAN-generated and raw images (0.84\u2009\u00b1\u20090.08 vs. 0.78\u2009\u00b1\u20090.11, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The motion artefact scores of the GAN-generated CCTA images of the pRCA and mRCA were significantly higher than those of the raw CCTA images (3 [4\u20133] vs 4 [5\u20134], <jats:italic>p<\/jats:italic>\u2009=\u20090.022; 3 [3\u20132] vs 5[5\u20134], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A GAN can significantly reduce the motion artefacts in CCTA images of the middle segment of the RCA and has the potential to act as a new method to remove motion artefacts in coronary CCTA images.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12880-022-00914-2","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:03:01Z","timestamp":1666929781000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Motion artefact reduction in coronary CT angiography images with a deep learning method"],"prefix":"10.1186","volume":"22","author":[{"given":"Pengling","family":"Ren","sequence":"first","affiliation":[]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Jiaxin","family":"Cao","sequence":"additional","affiliation":[]},{"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"issue":"4","key":"914_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41569-018-0119-4","volume":"16","author":"D Zhao","year":"2019","unstructured":"Zhao D, Liu J, Wang M, Zhang X, Zhou MJNRC. 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The requirement of informed consent from the patients was waived by the Research Ethics Board of Beijing Friendship Hospital, Capital Medical University. All methods were carried out in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that there is no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"184"}}